Elucidation of the treatment mechanism of pulsed radiofrequency based on its antiinflammatory effects

Yuba, Tomoo; Koyama, Yoshihisa; Uematsu, Hironobu et al.

Scientific Reports, 2025, 15, 33611

アクセス数:116件（2026-02-16 04:15 集計）

固定URL: https://hdl.handle.net/11094/103505

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タイトル
Elucidation of the treatment mechanism of pulsed radiofrequency based on its antiinflammatory effects
著者
ORCID
0009-0003-8090-6047 0009-0003-8090-6047
researchmap permalink
tomoo-yuba tomoo-yuba
Scopus Author ID
59014175800 59014175800
著者名
Yuba, Tomoo
NRID
1000040397667 1000040397667
researchmap permalink
koyamayoshihisa koyamayoshihisa
Scopus Author ID
49761644100 49761644100
著者名
Koyama, Yoshihisa
NRID
1000070467554 1000070467554
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H_Uematsu H_Uematsu
Scopus Author ID
35742251000 35742251000
著者名
Uematsu, Hironobu
NRID
1000070444544 1000070444544
researchmap permalink
takahashi_a takahashi_a
Scopus Author ID
56720024400 56720024400
著者名
Takahashi, Ayako
NRID
1000000397754 1000000397754
ORCID
0000-0002-8963-264X 0000-0002-8963-264X
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rsmap rsmap
Scopus Author ID
55118922800 55118922800
著者名
Matsuda, Yoichi
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y_fujino y_fujino
Scopus Author ID
19134445600 19134445600
著者名
Fujino, Yuji
NRID
1000020216063 1000020216063
ORCID
0000-0001-5369-1069 0000-0001-5369-1069
researchmap permalink
556shimada 556shimada
Scopus Author ID
35452177800 35452177800
著者名
Shimada, Shoichi
キーワード等
Analgesic effect
Anti-inflammatory effect
Calcitonin gene-related peptide
Knee pain
Pulsed radiofrequency
Substance p
内容
Yuba T., Koyama Y., Uematsu H., et al. Elucidation of the treatment mechanism of pulsed radiofrequency based on its antiinflammatory effects. Scientific Reports 15, 33611 (2025); https://doi.org/10.1038/s41598-025-19045-z.
抄録
Pulsed radiofrequency (PRF) is recognized as an effective pain relief for treating chronic pain, though the mechanism of the analgesic effect remains unclear. Recent studies have focused on the potential anti-inflammatory effect in analgesia through PRF. Therefore, we investigated the anti-inflammatory effects of PRF using the knee pain mouse models induced by monoiodoacetic acid. Our findings demonstrated that PRF on the sciatic nerve significantly reduces knee pain, synovitis, and inflammatory cytokines, thereby supporting the hypothesis that PRF exerts an anti-inflammatory effect. Moreover, a tracer study and western blotting analysis revealed that PRF inhibited axonal transport in small dorsal root ganglion (DRG) neurons in the spinal cord and suppressed the secretion of calcitonin gene-related peptide (CGRP) and substance P (SP), both of which are associated with persistent inflammation, into the knee joint. Finally, the administration of both CGRP and SP agonists to the knee joint nullified the analgesic and anti-inflammatory effects of PRF. In conclusion, our studies revealed that PRF exerted analgesic effects based on anti-inflammatory effects through inhibition of CGRP and SP secretion caused by impaired axonal transport in small DRG neurons. We hope that these findings will lead to further dissemination of PRF treatment in the future.
出版者
Nature Research
収録物名
Scientific Reports
巻(号)
15
ページ
33611
刊行年月
2025-09-29
言語
英語
ハンドルURL
https://hdl.handle.net/11094/103505
eISSN
20452322
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1038/s41598-025-19045-z
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article