Diurnal variations and intermittent arousals modulate jaw-opening and -closing muscle activity level during sleep in rats

Zhu, Yiwen; Yamada, Masaharu; Minota, Noriko; Katagiri, Ayano; Kato, Takafumi

doi:https://doi.org/10.1016/j.neuroscience.2025.10.002

Diurnal variations and intermittent arousals modulate jaw-opening and -closing muscle activity level during sleep in rats

Zhu, Yiwen; Yamada, Masaharu; Minota, Noriko et al.

Neuroscience, 2025, 588, 100-111

アクセス数:64件（2026-02-16 03:44 集計）

固定URL: https://hdl.handle.net/11094/103507

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タイトル	Diurnal variations and intermittent arousals modulate jaw-opening and -closing muscle activity level during sleep in rats
著者	ORCID 0009-0005-2216-5951 0009-0005-2216-5951 Scopus Author ID 58197218800 58197218800 著者名 Zhu, Yiwen
	著者名 Yamada, Masaharu
	著者名 Minota, Noriko
	NRID 1000040731899 1000040731899 ORCID 0000-0001-7381-8557 0000-0001-7381-8557 researchmap permalink katagiri-ayano katagiri-ayano Scopus Author ID 47161239400 47161239400 著者名 Katagiri, Ayano
	NRID 1000050367520 1000050367520 ORCID 0000-0003-2452-7328 0000-0003-2452-7328 researchmap permalink read0111598_hrfc15 read0111598_hrfc15 Scopus Author ID 57210579311 57210579311 著者名 Kato, Takafumi
キーワード等	Diurnal variation
	Intermittent arousal
	Jaw muscle activity
	Sleep-wake cycle
内容	Zhu Y., Yamada M., Minota N., et al. Diurnal variations and intermittent arousals modulate jaw-opening and -closing muscle activity level during sleep in rats. Neuroscience 588, 100 (2025); https://doi.org/10.1016/j.neuroscience.2025.10.002.
抄録	Increased jaw muscle activity during sleep, which is associated with conditions such as sleep bruxism and obstructive sleep apnea, is a significant clinical concern in dentistry. The present study aimed to investigate the factor influencing natural variations on jaw muscle activity during sleep throughout 24 h. In ten male SD rats, electrophysiological recording was conducted to monitor electroencephalography (EEG), electromyographic (EMG) activity of neck, jaw-closing (masseter), and jaw-opening (digastric) muscles while freely behaving throughout 24 h. Jaw muscle activity level during sleep exhibit a diurnal variation, with lower level in the light phase than in the early dark phase. The jaw muscle activity level was significantly higher during intermittent arousals than during quiet sleep period. Jaw muscle activity levels during intermittent arousals were significantly higher in dark phase within arousals during NREM sleep. Within intermittent arousals, jaw muscle activity level was negatively correlated with EEG delta power in NREM sleep or EEG theta power in REM sleep. Clustering analysis further revealed that multiple muscles including neck and jaw muscles are often activated within intermittent arousals. These findings revealed the occurrence of intermittent arousals under diurnal influences underlie the variations of jaw muscle activity during sleep in 24 h.
出版者	Elsevier Ltd
収録物名	Neuroscience
巻(号)	588
ページ	100-111
刊行年月	2025-10-18
言語	英語
ハンドルURL	https://hdl.handle.net/11094/103507
PISSN	03064522
eISSN	18737544
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.neuroscience.2025.10.002
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Neuroscience. 2025, 588, p. 100-111
DC.title	Diurnal variations and intermittent arousals modulate jaw-opening and -closing muscle activity level during sleep in rats
DC.creator	Zhu, Yiwen
	Yamada, Masaharu
	Minota, Noriko
	Katagiri, Ayano
	Kato, Takafumi
DC.publisher	Elsevier Ltd
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-10-18
DC.identifier	https://doi.org/10.1016/j.neuroscience.2025.10.002
DC.subject	Diurnal variation
	Intermittent arousal
	Jaw muscle activity
	Sleep-wake cycle
DC.description	Zhu Y., Yamada M., Minota N., et al. Diurnal variations and intermittent arousals modulate jaw-opening and -closing muscle activity level during sleep in rats. Neuroscience 588, 100 (2025); https://doi.org/10.1016/j.neuroscience.2025.10.002.
DCTERMS.abstract	Increased jaw muscle activity during sleep, which is associated with conditions such as sleep bruxism and obstructive sleep apnea, is a significant clinical concern in dentistry. The present study aimed to investigate the factor influencing natural variations on jaw muscle activity during sleep throughout 24 h. In ten male SD rats, electrophysiological recording was conducted to monitor electroencephalography (EEG), electromyographic (EMG) activity of neck, jaw-closing (masseter), and jaw-opening (digastric) muscles while freely behaving throughout 24 h. Jaw muscle activity level during sleep exhibit a diurnal variation, with lower level in the light phase than in the early dark phase. The jaw muscle activity level was significantly higher during intermittent arousals than during quiet sleep period. Jaw muscle activity levels during intermittent arousals were significantly higher in dark phase within arousals during NREM sleep. Within intermittent arousals, jaw muscle activity level was negatively correlated with EEG delta power in NREM sleep or EEG theta power in REM sleep. Clustering analysis further revealed that multiple muscles including neck and jaw muscles are often activated within intermittent arousals. These findings revealed the occurrence of intermittent arousals under diurnal influences underlie the variations of jaw muscle activity during sleep in 24 h.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	103507
citation_title	Diurnal variations and intermittent arousals modulate jaw-opening and -closing muscle activity level during sleep in rats
citation_author	Zhu, Yiwen
	Yamada, Masaharu
	Minota, Noriko
	Katagiri, Ayano
	Kato, Takafumi
citation_publisher	Elsevier Ltd
citation_language	英語
citation_date	2025-10-18
citation_journal_title	Neuroscience
citation_volume	588
citation_firstpage	100
citation_lastpage	111
citation_doi	https://doi.org/10.1016/j.neuroscience.2025.10.002
citation_public_url	https://hdl.handle.net/11094/103507

Diurnal variations and intermittent arousals modulate jaw-opening and -closing muscle activity level during sleep in rats

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