Dextrin utilization in Streptococcus pyogenes pathogenesis and growth

Hirose, Yujiro; Nizet, Victor; Kawabata, Shigetada

doi:https://doi.org/10.1016/j.job.2025.100704

Dextrin utilization in Streptococcus pyogenes pathogenesis and growth

Hirose, Yujiro; Nizet, Victor; Kawabata, Shigetada

Journal of Oral Biosciences, 2025, 67(4), 100704

アクセス数:48件（2026-02-16 10:17 集計）

固定URL: https://hdl.handle.net/11094/103518

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タイトル	Dextrin utilization in Streptococcus pyogenes pathogenesis and growth
著者	NRID 1000090788407 1000090788407 ORCID 0000-0001-6338-4767 0000-0001-6338-4767 researchmap permalink YujiroHirose YujiroHirose Scopus Author ID 56816348400 56816348400 著者名 Hirose, Yujiro
	著者名 Nizet, Victor
	NRID 1000050273694 1000050273694 researchmap permalink read0185239 read0185239 Scopus Author ID 7201354003 7201354003 著者名 Kawabata, Shigetada
キーワード等	Arginine
	Dextrin
	Growth
	Streptococcus pyogenes
	Virulence
内容	Hirose Y., Nizet V., Kawabata S.. Dextrin utilization in Streptococcus pyogenes pathogenesis and growth. Journal of Oral Biosciences 67, 100704 (2025); https://doi.org/10.1016/j.job.2025.100704.
抄録	Background: Streptococcus pyogenes has several clinical manifestations, from mild pharyngitis to life-threatening necrotizing fasciitis. Nutrient conditions strongly influence its virulence, and the ability to metabolize dextrin contributes to growth and pathogenicity. Since dextrin-dependent phenotypes link metabolic adaptation with virulence regulation, reviewing the current knowledge is essential for understanding how carbohydrate utilization shapes S. pyogenes pathogenesis and proliferation. Highlight: Animal models have demonstrated that the maltose/dextrin utilization operon enhances fitness and is co-activated with major toxins at infection sites. System-level analyses have shown that dextrin induces the nga–ifs–slo operon and activates CovRS-associated modules, a regulatory system central to virulence control. Dextrin also promotes in vitro growth, with genome-scale metabolic modeling implicating increased arginine metabolism in this phenotype. Collectively, these results suggest that dextrin acts as a regulatory cue to reprogram virulence and metabolic capacity. Conclusion: Dextrin utilization shapes both the growth and virulence of S. pyogenes. Although the mechanisms remain incompletely defined, integrating metabolic modeling with experimental approaches will be crucial for clarifying how carbohydrate use drives invasive diseases.
出版者	Japanese Association for Oral Biology
収録物名	Journal of Oral Biosciences
巻(号)	67(4)
ページ	100704
刊行年月	2025-10-22
言語	英語
ハンドルURL	https://hdl.handle.net/11094/103518
PISSN	13490079
eISSN	18803865
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.job.2025.100704
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of Oral Biosciences. 2025, 67(4), p. 100704
DC.title	Dextrin utilization in Streptococcus pyogenes pathogenesis and growth
DC.creator	Hirose, Yujiro
	Nizet, Victor
	Kawabata, Shigetada
DC.publisher	Japanese Association for Oral Biology
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-10-22
DC.identifier	https://doi.org/10.1016/j.job.2025.100704
DC.subject	Arginine
	Dextrin
	Growth
	Streptococcus pyogenes
	Virulence
DC.description	Hirose Y., Nizet V., Kawabata S.. Dextrin utilization in Streptococcus pyogenes pathogenesis and growth. Journal of Oral Biosciences 67, 100704 (2025); https://doi.org/10.1016/j.job.2025.100704.
DCTERMS.abstract	Background: Streptococcus pyogenes has several clinical manifestations, from mild pharyngitis to life-threatening necrotizing fasciitis. Nutrient conditions strongly influence its virulence, and the ability to metabolize dextrin contributes to growth and pathogenicity. Since dextrin-dependent phenotypes link metabolic adaptation with virulence regulation, reviewing the current knowledge is essential for understanding how carbohydrate utilization shapes S. pyogenes pathogenesis and proliferation. Highlight: Animal models have demonstrated that the maltose/dextrin utilization operon enhances fitness and is co-activated with major toxins at infection sites. System-level analyses have shown that dextrin induces the nga–ifs–slo operon and activates CovRS-associated modules, a regulatory system central to virulence control. Dextrin also promotes in vitro growth, with genome-scale metabolic modeling implicating increased arginine metabolism in this phenotype. Collectively, these results suggest that dextrin acts as a regulatory cue to reprogram virulence and metabolic capacity. Conclusion: Dextrin utilization shapes both the growth and virulence of S. pyogenes. Although the mechanisms remain incompletely defined, integrating metabolic modeling with experimental approaches will be crucial for clarifying how carbohydrate use drives invasive diseases.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	103518
citation_title	Dextrin utilization in Streptococcus pyogenes pathogenesis and growth
citation_author	Hirose, Yujiro
	Nizet, Victor
	Kawabata, Shigetada
citation_publisher	Japanese Association for Oral Biology
citation_language	英語
citation_date	2025-10-22
citation_journal_title	Journal of Oral Biosciences
citation_volume	67
citation_issue	4
citation_firstpage	100704
citation_doi	https://doi.org/10.1016/j.job.2025.100704
citation_public_url	https://hdl.handle.net/11094/103518

Dextrin utilization in Streptococcus pyogenes pathogenesis and growth

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