Gross Chromosomal Rearrangement at Centromeres

Xu, Ran; Pan, Ziyi; Nakagawa, Takuro

Biomolecules, 2023, 14(1), 28

アクセス数:48件（2026-02-15 18:42 集計）

固定URL: https://hdl.handle.net/11094/103529

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タイトル
Gross Chromosomal Rearrangement at Centromeres
著者
著者名
Xu, Ran
著者名
Pan, Ziyi
NRID
1000020324866 1000020324866
ORCID
0000-0003-3455-8224 0000-0003-3455-8224
researchmap permalink
read0068709 read0068709
Scopus Author ID
57202699267 57202699267
著者名
Nakagawa, Takuro
キーワード等
CENP-A
centromere
DNA recombination
DNA repair
DNA repeat
fission yeast
gross chromosomal rearrangement
heterochromatin
humans
isochromosome
内容
Xu R., Pan Z., Nakagawa T.. Gross Chromosomal Rearrangement at Centromeres. Biomolecules 14, 28 (2024); https://doi.org/10.3390/biom14010028.
抄録
Centromeres play essential roles in the faithful segregation of chromosomes. CENP-A, the centromere-specific histone H3 variant, and heterochromatin characterized by di- or tri-methylation of histone H3 9th lysine (H3K9) are the hallmarks of centromere chromatin. Contrary to the epigenetic marks, DNA sequences underlying the centromere region of chromosomes are not well conserved through evolution. However, centromeres consist of repetitive sequences in many eukaryotes, including animals, plants, and a subset of fungi, including fission yeast. Advances in long-read sequencing techniques have uncovered the complete sequence of human centromeres containing more than thousands of alpha satellite repeats and other types of repetitive sequences. Not only tandem but also inverted repeats are present at a centromere. DNA recombination between centromere repeats can result in gross chromosomal rearrangement (GCR), such as translocation and isochromosome formation. CENP-A chromatin and heterochromatin suppress the centromeric GCR. The key player of homologous recombination, Rad51, safeguards centromere integrity through conservative noncrossover recombination between centromere repeats. In contrast to Rad51-dependent recombination, Rad52-mediated single-strand annealing (SSA) and microhomology-mediated end-joining (MMEJ) lead to centromeric GCR. This review summarizes recent findings on the role of centromere and recombination proteins in maintaining centromere integrity and discusses how GCR occurs at centromeres.
出版者
Multidisciplinary Digital Publishing Institute (MDPI)
収録物名
Biomolecules
巻(号)
14(1)
ページ
28
刊行年月
2023-12-24
言語
英語
ハンドルURL
https://hdl.handle.net/11094/103529
eISSN
2218273X
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.3390/biom14010028
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution 4.0 International License.
© 2023 by the authors.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article