Higher risk of respiratory infections and otitis media in cleft lip and/or palate patients: the Japan Environment and Children’s Study

Kurosaka, Hiroshi; Kimura, Takashi; Dong, Jia Yi; Cui, Meishan; Ikehara, Satoyo; Ueda, Kimiko; Iso, Hiroyasu; Yamashiro, Takashi; the Japan Environment and Children’s Study Group

doi:https://doi.org/10.1265/ehpm.24-00150

Higher risk of respiratory infections and otitis media in cleft lip and/or palate patients: the Japan Environment and Children’s Study

Kurosaka, Hiroshi; Kimura, Takashi; Dong, Jia Yi et al.

Environmental Health and Preventive Medicine, 2024, 29, 66

アクセス数:77件（2026-02-16 00:34 集計）

固定URL: https://hdl.handle.net/11094/103546

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タイトル	Higher risk of respiratory infections and otitis media in cleft lip and/or palate patients: the Japan Environment and Children’s Study
著者	NRID 1000020509369 1000020509369 ORCID 0000-0002-8956-5467 0000-0002-8956-5467 researchmap permalink kurosakahiroshi kurosakahiroshi Scopus Author ID 11839162500 11839162500 著者名 Kurosaka, Hiroshi
	NRID 1000020775613 1000020775613 著者名 Kimura, Takashi
	NRID 1000090823625 1000090823625 著者名 Dong, Jia Yi
	NRID 1000070823673 1000070823673 ORCID 0000-0001-7521-1900 0000-0001-7521-1900 researchmap permalink saimiyoshi saimiyoshi Scopus Author ID 57193542088 57193542088 著者名 Cui, Meishan
	NRID 1000070589465 1000070589465 著者名 Ikehara, Satoyo
	NRID 1000060538081 1000060538081 著者名 Ueda, Kimiko
	NRID 1000050223053 1000050223053 researchmap permalink read0018235 read0018235 著者名 Iso, Hiroyasu
	NRID 1000070294428 1000070294428 ORCID 0000-0002-4419-9643 0000-0002-4419-9643 researchmap permalink read0051793 read0051793 Scopus Author ID 55416765600 55416765600 著者名 Yamashiro, Takashi
	著者名 the Japan Environment and Children’s Study Group
キーワード等	Cleft lip and/or palate
	Large cohort
	Otitis media
	Upper respiratory inflammation
内容	Kurosaka H., Kimura T., Dong J.Y., et al. Higher risk of respiratory infections and otitis media in cleft lip and/or palate patients: the Japan Environment and Children’s Study. Environmental Health and Preventive Medicine 29, 66 (2024); https://doi.org/10.1265/ehpm.24-00150.
抄録	Background: Cleft lip and/or palate (CL/P) is one of the most frequent craniofacial disorder which could associate with a wide range of craniofacial complication. In order to perform comprehensive care of CL/P patients, it is crucial to elucidate the link of CL/P and general clinical conditions. This study aims to elucidate the relationships between medical history of different CL/P types and infectious diseases to serve as a reference for the comprehensive care of patients with CL/P. Methods: We investigated the association between a history different types of CL/P and the risk of infectious diseases among 1-year old children in the Japan Environment and Children’s Study (JECS). Among the 104,065 registered fetal records, 92,590 eligible participants were included in the analysis. Results: The multivariable-adjusted risk ratios (95% confidence intervals) for otitis media were increased in cleft lip and palate (CLP) and cleft palate only (CPO) groups by 3.81 (2.73–5.31) and 2.27 (1.22–4.22), respectively. The prevalence of Upper respiratory inflammation (URTI) was not associated with CLP, cleft lip only, or CPO. However, analysis in all groups showed a higher risk of URTI compared with the control group (1.31 [1.04–1.66]). Conclusions: CL/P care requires additional attention to prevent airway infectious diseases such as URTI before 1 year of age. Further research is warranted to elucidate the relationship between CL/P and general medical conditions.
出版者	Komiyama Printing Co., Ltd.
収録物名	Environmental Health and Preventive Medicine
巻(号)	29
ページ	66
刊行年月	2024-11-27
言語	英語
ハンドルURL	https://hdl.handle.net/11094/103546
PISSN	1342078X
eISSN	13474715
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1265/ehpm.24-00150
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Environmental Health and Preventive Medicine. 2024, 29, p. 66
DC.title	Higher risk of respiratory infections and otitis media in cleft lip and/or palate patients: the Japan Environment and Children’s Study
DC.creator	Kurosaka, Hiroshi
	Kimura, Takashi
	Dong, Jia Yi
	Cui, Meishan
	Ikehara, Satoyo
	Ueda, Kimiko
	Iso, Hiroyasu
	Yamashiro, Takashi
	the Japan Environment and Children’s Study Group
DC.publisher	Komiyama Printing Co., Ltd.
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2024-11-27
DC.identifier	https://doi.org/10.1265/ehpm.24-00150
DC.subject	Cleft lip and/or palate
	Large cohort
	Otitis media
	Upper respiratory inflammation
DC.description	Kurosaka H., Kimura T., Dong J.Y., et al. Higher risk of respiratory infections and otitis media in cleft lip and/or palate patients: the Japan Environment and Children’s Study. Environmental Health and Preventive Medicine 29, 66 (2024); https://doi.org/10.1265/ehpm.24-00150.
DCTERMS.abstract	Background: Cleft lip and/or palate (CL/P) is one of the most frequent craniofacial disorder which could associate with a wide range of craniofacial complication. In order to perform comprehensive care of CL/P patients, it is crucial to elucidate the link of CL/P and general clinical conditions. This study aims to elucidate the relationships between medical history of different CL/P types and infectious diseases to serve as a reference for the comprehensive care of patients with CL/P. Methods: We investigated the association between a history different types of CL/P and the risk of infectious diseases among 1-year old children in the Japan Environment and Children’s Study (JECS). Among the 104,065 registered fetal records, 92,590 eligible participants were included in the analysis. Results: The multivariable-adjusted risk ratios (95% confidence intervals) for otitis media were increased in cleft lip and palate (CLP) and cleft palate only (CPO) groups by 3.81 (2.73–5.31) and 2.27 (1.22–4.22), respectively. The prevalence of Upper respiratory inflammation (URTI) was not associated with CLP, cleft lip only, or CPO. However, analysis in all groups showed a higher risk of URTI compared with the control group (1.31 [1.04–1.66]). Conclusions: CL/P care requires additional attention to prevent airway infectious diseases such as URTI before 1 year of age. Further research is warranted to elucidate the relationship between CL/P and general medical conditions.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	103546
citation_title	Higher risk of respiratory infections and otitis media in cleft lip and/or palate patients: the Japan Environment and Children’s Study
citation_author	Kurosaka, Hiroshi
	Kimura, Takashi
	Dong, Jia Yi
	Cui, Meishan
	Ikehara, Satoyo
	Ueda, Kimiko
	Iso, Hiroyasu
	Yamashiro, Takashi
	the Japan Environment and Children’s Study Group
citation_publisher	Komiyama Printing Co., Ltd.
citation_language	英語
citation_date	2024-11-27
citation_journal_title	Environmental Health and Preventive Medicine
citation_volume	29
citation_firstpage	66
citation_doi	https://doi.org/10.1265/ehpm.24-00150
citation_public_url	https://hdl.handle.net/11094/103546

Higher risk of respiratory infections and otitis media in cleft lip and/or palate patients: the Japan Environment and Children’s Study

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