Hydroxypropyl Cellulose Enhances Immune Responses to the Current Seasonal Influenza Vaccine in Mice

Kaewaroon, Nantaporn; Yoshimoto, Sara; Muawan, Luthfi; Shichinohe, Shintaro; Watanabe, Tokiko

doi:https://doi.org/10.1111/1348-0421.70026

Hydroxypropyl Cellulose Enhances Immune Responses to the Current Seasonal Influenza Vaccine in Mice

Kaewaroon, Nantaporn; Yoshimoto, Sara; Muawan, Luthfi et al.

Microbiology and Immunology, 2025

アクセス数:69件（2026-02-15 22:21 集計）

固定URL: https://hdl.handle.net/11094/103585

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タイトル	Hydroxypropyl Cellulose Enhances Immune Responses to the Current Seasonal Influenza Vaccine in Mice
著者	著者名 Kaewaroon, Nantaporn
	著者名 Yoshimoto, Sara
	著者名 Muawan, Luthfi
	NRID 1000080737148 1000080737148 researchmap permalink shichi_ shichi_ Scopus Author ID 54993583800 54993583800 ORCID 0000-0002-8783-2103 0000-0002-8783-2103 著者名 Shichinohe, Shintaro
	NRID 1000060557479 1000060557479 researchmap permalink toki_watanabe toki_watanabe Scopus Author ID 8926021900 8926021900 ORCID 0000-0001-6461-5379 0000-0001-6461-5379 著者名 Watanabe, Tokiko
キーワード等	adjuvant
	hydroxypropyl cellulose
	seasonal influenza vaccine
内容	Kaewaroon N., Yoshimoto S., Muawan L., et al. Hydroxypropyl Cellulose Enhances Immune Responses to the Current Seasonal Influenza Vaccine in Mice. Microbiology and Immunology , (2025); https://doi.org/10.1111/1348-0421.70026.
抄録	Influenza A and B viruses cause annual epidemics and continue to pose global public health concerns. The most effective approach to preventing or mitigating the severity of influenza is vaccination. Inactivated split influenza HA vaccines are commonly used worldwide due to their strong safety profile and broad range of target groups; however, their efficacy is suboptimal, especially in the elderly. Adjuvants are used to enhance the effectiveness of some influenza vaccines, but few adjuvants have been approved for human vaccines. Previously, we identified hydroxypropyl cellulose as a promising adjuvant for the split influenza HA vaccine for the 2015–2016 and 2016–2017 influenza seasons. Here, we evaluated whether hydroxypropyl cellulose could enhance the efficacy of the quadrivalent split HA vaccine for the 2023–2024 influenza season, which contains the HA proteins of A/Victoria/4897/2022 (H1N1)pdm09 and three other strains. Using a mouse model, we performed immunogenicity studies and assessed protective efficacy against challenges with homologous and heterologous H1N1pdm09 virus strains. We found that hydroxypropyl cellulose in combination with the HA vaccine generated higher virus-specific IgG antibody titers compared to the vaccine alone. The adjuvanted vaccine provided complete protection against homologous challenge and enhanced viral clearance from respiratory organs. Notably, the adjuvanted vaccine demonstrated cross-protective efficacy against heterologous H1N1pdm09 virus challenge, improving survival rates compared to vaccine alone. Our results demonstrate that hydroxypropyl cellulose has potential as an adjuvant for current seasonal influenza vaccines.
出版者	John Wiley and Sons Inc
収録物名	Microbiology and Immunology
刊行年月	2025-12-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/103585
PISSN	03855600
eISSN	13480421
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1111/1348-0421.70026
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Microbiology and Immunology. 2025
DC.title	Hydroxypropyl Cellulose Enhances Immune Responses to the Current Seasonal Influenza Vaccine in Mice
DC.creator	Kaewaroon, Nantaporn
	Yoshimoto, Sara
	Muawan, Luthfi
	Shichinohe, Shintaro
	Watanabe, Tokiko
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-12-01
DC.identifier	https://doi.org/10.1111/1348-0421.70026
DC.subject	adjuvant
	hydroxypropyl cellulose
	seasonal influenza vaccine
DC.description	Kaewaroon N., Yoshimoto S., Muawan L., et al. Hydroxypropyl Cellulose Enhances Immune Responses to the Current Seasonal Influenza Vaccine in Mice. Microbiology and Immunology , (2025); https://doi.org/10.1111/1348-0421.70026.
DCTERMS.abstract	Influenza A and B viruses cause annual epidemics and continue to pose global public health concerns. The most effective approach to preventing or mitigating the severity of influenza is vaccination. Inactivated split influenza HA vaccines are commonly used worldwide due to their strong safety profile and broad range of target groups; however, their efficacy is suboptimal, especially in the elderly. Adjuvants are used to enhance the effectiveness of some influenza vaccines, but few adjuvants have been approved for human vaccines. Previously, we identified hydroxypropyl cellulose as a promising adjuvant for the split influenza HA vaccine for the 2015–2016 and 2016–2017 influenza seasons. Here, we evaluated whether hydroxypropyl cellulose could enhance the efficacy of the quadrivalent split HA vaccine for the 2023–2024 influenza season, which contains the HA proteins of A/Victoria/4897/2022 (H1N1)pdm09 and three other strains. Using a mouse model, we performed immunogenicity studies and assessed protective efficacy against challenges with homologous and heterologous H1N1pdm09 virus strains. We found that hydroxypropyl cellulose in combination with the HA vaccine generated higher virus-specific IgG antibody titers compared to the vaccine alone. The adjuvanted vaccine provided complete protection against homologous challenge and enhanced viral clearance from respiratory organs. Notably, the adjuvanted vaccine demonstrated cross-protective efficacy against heterologous H1N1pdm09 virus challenge, improving survival rates compared to vaccine alone. Our results demonstrate that hydroxypropyl cellulose has potential as an adjuvant for current seasonal influenza vaccines.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	103585
citation_title	Hydroxypropyl Cellulose Enhances Immune Responses to the Current Seasonal Influenza Vaccine in Mice
citation_author	Kaewaroon, Nantaporn
	Yoshimoto, Sara
	Muawan, Luthfi
	Shichinohe, Shintaro
	Watanabe, Tokiko
citation_publisher	John Wiley and Sons Inc
citation_language	英語
citation_date	2025-12-01
citation_journal_title	Microbiology and Immunology
citation_doi	https://doi.org/10.1111/1348-0421.70026
citation_public_url	https://hdl.handle.net/11094/103585

Hydroxypropyl Cellulose Enhances Immune Responses to the Current Seasonal Influenza Vaccine in Mice

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