TGF-β in jaw tumor fluids induces RANKL expression in stromal fibroblasts

Yamada, Chiaki; Aikawa, Tomonao; Okuno, Emi et al.

International Journal of Oncology, 2016, 49(2), 499-508

アクセス数:70件（2026-02-15 21:10 集計）

固定URL: https://hdl.handle.net/11094/103652

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タイトル
TGF-β in jaw tumor fluids induces RANKL expression in stromal fibroblasts
著者
NRID
1000080548818 1000080548818
著者名
Yamada, Chiaki
NRID
1000000362674 1000000362674
ORCID
0000-0001-6906-6874 0000-0001-6906-6874
researchmap permalink
AT003072 AT003072
Scopus Author ID
7102369836 7102369836
著者名
Aikawa, Tomonao
著者名
Okuno, Emi
NRID
1000050635381 1000050635381
ORCID
0000-0003-4014-1847 0000-0003-4014-1847
researchmap permalink
kaz-miyagawa kaz-miyagawa
Scopus Author ID
37012083900 37012083900
著者名
Miyagawa, Kazuaki
NRID
1000020448129 1000020448129
著者名
Amano, Katsuhiko
NRID
1000090964875 1000090964875
著者名
Takahata, Sosuke
NRID
1000090448134 1000090448134
著者名
Kimata, Masaaki
NRID
1000010281130 1000010281130
ORCID
0000-0001-7145-5641 0000-0001-7145-5641
researchmap permalink
read0046547 read0046547
Scopus Author ID
7004648970 7004648970
著者名
Okura, Masaya
NRID
1000040283791 1000040283791
著者名
Iida, Seiji
NRID
1000020205371 1000020205371
ORCID
0000-0002-4556-2491 0000-0002-4556-2491
researchmap permalink
4321Kogo2 4321Kogo2
Scopus Author ID
7003762492 7003762492
著者名
Kogo, Mikihiko
キーワード等
Interleukin-1
Keratocystic odontogenic tumor
Odontogenic tumor
Receptor activator of NF-B ligand
Transforming growth factor
内容
Yamada C., Aikawa T., Okuno E., et al. TGF-β in jaw tumor fluids induces RANKL expression in stromal fibroblasts. International Journal of Oncology 49, 499 (2016); https://doi.org/10.3892/ijo.2016.3548.
抄録
Odontogenic tumors and cysts, arising in the jawbones, grow by resorption and destruction of the jawbones. However, mechanisms underlying bone resorption by odontogenic tumors/cysts remain unclear. Odontogenic tumors/cysts comprise odontogenic epithelial cells and stromal fibroblasts, which originate from the developing tooth germ. It has been demonstrated that odontogenic epithelial cells of the developing tooth germ induce osteoclastogenesis to prevent the tooth germ from invading the developing bone to maintain its structure in developing bones. Thus, we hypothesized that odontogenic epithelial cells of odontogenic tumors/cysts induce osteoclast formation, which plays potential roles in tumor/cyst outgrowth into the jawbone. The purpose of this study was to examine osteoclastogenesis by cytokines, focusing on transforming growth factor-(TGF-), produced by odontogenic epithelial cells. We observed two pathways for receptor activator of NF-B ligand (RANKL) induction by keratocystic odontogenic tumor fluid: the cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway through interleukin-1 (IL-1) signaling and non-COX-2/PGE2 pathway through TGF receptor signaling. TGF-1 and IL-1 produced by odontogenic tumors/cysts induced osteoclastogenesis directly in the osteoclast precursor cells and indirectly via increased RANKL induction in the stroma.
出版者
Spandidos Publications
収録物名
International Journal of Oncology
巻(号)
49(2)
ページ
499-508
刊行年月
2016-03-31
言語
英語
ハンドルURL
https://hdl.handle.net/11094/103652
PISSN
10196439
eISSN
17912423
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.3892/ijo.2016.3548
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article