Preventive and Therapeutic Effects of Hydrogen-Generating Si-Based Agent on Pressure Ulcers in Mice

Otani, Naoya; Oue, Takaki; Kobayashi, Yuki; Kobayashi, Hikaru; Tomita, Koichi; Kubo, Tateki

doi:https://doi.org/10.3390/biomedicines13102475

Preventive and Therapeutic Effects of Hydrogen-Generating Si-Based Agent on Pressure Ulcers in Mice

Otani, Naoya; Oue, Takaki; Kobayashi, Yuki et al.

Biomedicines, 2025, 13(10), 2475

アクセス数:67件（2026-02-15 20:42 集計）

固定URL: https://hdl.handle.net/11094/103670

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タイトル	Preventive and Therapeutic Effects of Hydrogen-Generating Si-Based Agent on Pressure Ulcers in Mice
著者	NRID 1000000882268 1000000882268 researchmap permalink otani708 otani708 Scopus Author ID 57203983492 57203983492 著者名 Otani, Naoya
	NRID 1000041001457 1000041001457 著者名 Oue, Takaki
	NRID 1000040723557 1000040723557 researchmap permalink yuki-kobayashi_osaka yuki-kobayashi_osaka 著者名 Kobayashi, Yuki
	NRID 1000090195800 1000090195800 著者名 Kobayashi, Hikaru
	NRID 1000090423178 1000090423178 著者名 Tomita, Koichi
	NRID 1000000362707 1000000362707 ORCID 0000-0003-1402-5383 0000-0003-1402-5383 researchmap permalink read0106283 read0106283 Scopus Author ID 55600046500 55600046500 著者名 Kubo, Tateki
キーワード等	apoptosis
	hydrogen
	inflammation
	oxidative stress
	pressure ulcer
内容	Otani N., Oue T., Kobayashi Y., et al. Preventive and Therapeutic Effects of Hydrogen-Generating Si-Based Agent on Pressure Ulcers in Mice. Biomedicines 13, 2475 (2025); https://doi.org/https://doi.org/10.3390/biomedicines13102475.
抄録	Objectives: As a known antioxidant, hydrogen has been useful for treating pressure ulcers. However, conventional methods of hydrogen administration have limitations with regard to dosage and continuity of hydrogen intake. This study evaluated the efficacy of a novel Si-containing agent that can generate substantial quantities of hydrogen to treat pressure ulcers in an in vivo mouse model. Methods: The back skin and subcutaneous tissue of mice were compressed with magnets for 12 h. Changes in the ulcer area after release of compression, histological findings, degree of apoptosis, and expression levels for oxidative stress markers and inflammation-related cytokines were compared between mice fed a normal diet (control group) and those fed a 2.5 wt% Si-based diet (Si group). Results: The Si group had a significantly smaller ulcer area and shorter healing period than the control group. Moreover, inflammatory responses, apoptotic activity, and oxidative stress within the ulcer tissue were suppressed significantly in the Si group. Conclusions: Oral intake of the Si-based agent can potentially treat and prevent pressure ulcers by regulating apoptosis, oxidative stress, and inflammatory responses.
出版者	Multidisciplinary Digital Publishing Institute (MDPI)
収録物名	Biomedicines
巻(号)	13(10)
ページ	2475
刊行年月	2025-10-11
言語	英語
ハンドルURL	https://hdl.handle.net/11094/103670
eISSN	22279059
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.3390/biomedicines13102475
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Biomedicines. 2025, 13(10), p. 2475
DC.title	Preventive and Therapeutic Effects of Hydrogen-Generating Si-Based Agent on Pressure Ulcers in Mice
DC.creator	Otani, Naoya
	Oue, Takaki
	Kobayashi, Yuki
	Kobayashi, Hikaru
	Tomita, Koichi
	Kubo, Tateki
DC.publisher	Multidisciplinary Digital Publishing Institute (MDPI)
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-10-11
DC.identifier	https://doi.org/10.3390/biomedicines13102475
DC.subject	apoptosis
	hydrogen
	inflammation
	oxidative stress
	pressure ulcer
DC.description	Otani N., Oue T., Kobayashi Y., et al. Preventive and Therapeutic Effects of Hydrogen-Generating Si-Based Agent on Pressure Ulcers in Mice. Biomedicines 13, 2475 (2025); https://doi.org/https://doi.org/10.3390/biomedicines13102475.
DCTERMS.abstract	Objectives: As a known antioxidant, hydrogen has been useful for treating pressure ulcers. However, conventional methods of hydrogen administration have limitations with regard to dosage and continuity of hydrogen intake. This study evaluated the efficacy of a novel Si-containing agent that can generate substantial quantities of hydrogen to treat pressure ulcers in an in vivo mouse model. Methods: The back skin and subcutaneous tissue of mice were compressed with magnets for 12 h. Changes in the ulcer area after release of compression, histological findings, degree of apoptosis, and expression levels for oxidative stress markers and inflammation-related cytokines were compared between mice fed a normal diet (control group) and those fed a 2.5 wt% Si-based diet (Si group). Results: The Si group had a significantly smaller ulcer area and shorter healing period than the control group. Moreover, inflammatory responses, apoptotic activity, and oxidative stress within the ulcer tissue were suppressed significantly in the Si group. Conclusions: Oral intake of the Si-based agent can potentially treat and prevent pressure ulcers by regulating apoptosis, oxidative stress, and inflammatory responses.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	103670
citation_title	Preventive and Therapeutic Effects of Hydrogen-Generating Si-Based Agent on Pressure Ulcers in Mice
citation_author	Otani, Naoya
	Oue, Takaki
	Kobayashi, Yuki
	Kobayashi, Hikaru
	Tomita, Koichi
	Kubo, Tateki
citation_publisher	Multidisciplinary Digital Publishing Institute (MDPI)
citation_language	英語
citation_date	2025-10-11
citation_journal_title	Biomedicines
citation_volume	13
citation_issue	10
citation_firstpage	2475
citation_doi	https://doi.org/10.3390/biomedicines13102475
citation_public_url	https://hdl.handle.net/11094/103670

Preventive and Therapeutic Effects of Hydrogen-Generating Si-Based Agent on Pressure Ulcers in Mice

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