Development and validation of a risk assessment tool for ischemic stroke in cancer patients

Kawano, Tomohiro; Gon, Yasufumi; Morishima, Toshitaka; Takasugi, Junji; Kanki, Hideaki; Sasaki, Tsutomu; Miyashiro, Isao; Mochizuki, Hideki

doi:https://doi.org/10.1038/s41598-025-23958-0

Development and validation of a risk assessment tool for ischemic stroke in cancer patients

Kawano, Tomohiro; Gon, Yasufumi; Morishima, Toshitaka et al.

Scientific Reports, 2025, 15, 39560

アクセス数:24件（2026-02-15 19:31 集計）

固定URL: https://hdl.handle.net/11094/103686

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タイトル	Development and validation of a risk assessment tool for ischemic stroke in cancer patients
著者	NRID 1000000983181 1000000983181 ORCID 0000-0002-6282-4991 0000-0002-6282-4991 researchmap permalink tomohirokawano tomohirokawano Scopus Author ID 57192176743 57192176743 著者名 Kawano, Tomohiro
	NRID 1000070751311 1000070751311 ORCID 0000-0002-3907-1741 0000-0002-3907-1741 researchmap permalink y-gon y-gon Scopus Author ID 56565092900 56565092900 著者名 Gon, Yasufumi
	NRID 1000010728893 1000010728893 ORCID 0000-0002-0747-3287 0000-0002-0747-3287 researchmap permalink morishima morishima Scopus Author ID 57209878518 57209878518 著者名 Morishima, Toshitaka
	NRID 1000040796033 1000040796033 ORCID 0000-0002-6200-4571 0000-0002-6200-4571 researchmap permalink j-takasugi j-takasugi Scopus Author ID 55909103700 55909103700 著者名 Takasugi, Junji
	NRID 1000010774218 1000010774218 ORCID 0000-0001-8531-7645 0000-0001-8531-7645 researchmap permalink kan1 kan1 Scopus Author ID 58437295000 58437295000 著者名 Kanki, Hideaki
	NRID 1000020534879 1000020534879 ORCID 0000-0001-8726-978X 0000-0001-8726-978X researchmap permalink tsutomusasaki1111 tsutomusasaki1111 Scopus Author ID 7407394272 7407394272 著者名 Sasaki, Tsutomu
	NRID 1000080501824 1000080501824 著者名 Miyashiro, Isao
	NRID 1000090230044 1000090230044 ORCID 0000-0002-0874-7542 0000-0002-0874-7542 researchmap permalink read0207787 read0207787 Scopus Author ID 7202006099 7202006099 著者名 Mochizuki, Hideki
内容	Kawano T., Gon Y., Morishima T., et al. Development and validation of a risk assessment tool for ischemic stroke in cancer patients. Scientific Reports 15, 39560 (2025); https://doi.org/10.1038/s41598-025-23958-0.
抄録	Cancer patients have an increased risk of ischemic stroke. However, there is no reliable risk prediction model. We aimed to create a risk prediction model for ischemic stroke in cancer patients within the first 2 years after cancer diagnosis. A cohort of 26,717 cancer patients from the University of Osaka Hospital was used to develop the model. A cohort of 31,881 patients from Osaka International Cancer Institute was used for external validation. Data in the development cohort generated an AHANDS score: Age ≥ 75 years, Hypertension, Atrial fibrillation, a high Neutrophil-to-lymphocyte ratio, an elevated D-dimer level, and cancer Stage IV or distant metastasis at the time of cancer diagnosis. Discrimination was assessed using the c-statistic. We compared the AHANDS and Khorana scores in the development cohort. Ischemic stroke occurred within 2 years of diagnosis of cancer in 163 patients (0.61%) in the development cohort and in 99 (0.31%) in the validation cohort. The AHANDS score performed better than the Khorana score (c-statistic 0.703 vs. 0.54; p < 0.0001). A similar result was obtained in the external validation cohort (c-statistic 0.75). This score is intended to guide future stroke prevention strategies in patients with cancer.
出版者	Nature Research
収録物名	Scientific Reports
巻(号)	15
ページ	39560
刊行年月	2025-11-12
言語	英語
ハンドルURL	https://hdl.handle.net/11094/103686
eISSN	20452322
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1038/s41598-025-23958-0
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Scientific Reports. 2025, 15, p. 39560
DC.title	Development and validation of a risk assessment tool for ischemic stroke in cancer patients
DC.creator	Kawano, Tomohiro
	Gon, Yasufumi
	Morishima, Toshitaka
	Takasugi, Junji
	Kanki, Hideaki
	Sasaki, Tsutomu
	Miyashiro, Isao
	Mochizuki, Hideki
DC.publisher	Nature Research
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-11-12
DC.identifier	https://doi.org/10.1038/s41598-025-23958-0
DC.description	Kawano T., Gon Y., Morishima T., et al. Development and validation of a risk assessment tool for ischemic stroke in cancer patients. Scientific Reports 15, 39560 (2025); https://doi.org/10.1038/s41598-025-23958-0.
DCTERMS.abstract	Cancer patients have an increased risk of ischemic stroke. However, there is no reliable risk prediction model. We aimed to create a risk prediction model for ischemic stroke in cancer patients within the first 2 years after cancer diagnosis. A cohort of 26,717 cancer patients from the University of Osaka Hospital was used to develop the model. A cohort of 31,881 patients from Osaka International Cancer Institute was used for external validation. Data in the development cohort generated an AHANDS score: Age ≥ 75 years, Hypertension, Atrial fibrillation, a high Neutrophil-to-lymphocyte ratio, an elevated D-dimer level, and cancer Stage IV or distant metastasis at the time of cancer diagnosis. Discrimination was assessed using the c-statistic. We compared the AHANDS and Khorana scores in the development cohort. Ischemic stroke occurred within 2 years of diagnosis of cancer in 163 patients (0.61%) in the development cohort and in 99 (0.31%) in the validation cohort. The AHANDS score performed better than the Khorana score (c-statistic 0.703 vs. 0.54; p < 0.0001). A similar result was obtained in the external validation cohort (c-statistic 0.75). This score is intended to guide future stroke prevention strategies in patients with cancer.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	103686
citation_title	Development and validation of a risk assessment tool for ischemic stroke in cancer patients
citation_author	Kawano, Tomohiro
	Gon, Yasufumi
	Morishima, Toshitaka
	Takasugi, Junji
	Kanki, Hideaki
	Sasaki, Tsutomu
	Miyashiro, Isao
	Mochizuki, Hideki
citation_publisher	Nature Research
citation_language	英語
citation_date	2025-11-12
citation_journal_title	Scientific Reports
citation_volume	15
citation_firstpage	39560
citation_doi	https://doi.org/10.1038/s41598-025-23958-0
citation_public_url	https://hdl.handle.net/11094/103686

Development and validation of a risk assessment tool for ischemic stroke in cancer patients

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