Association between the timing of secondary alveolar bone grafting and maxillary permanent central incisor development in unilateral cleft lip and palate

Saka, Akihiro; Nishizawa, Chiaki; Matsushita, Yutaka; Michigami, Toshimi; Tanaka, Susumu; Isomura, Emiko Tanaka; Kogo, Mikihiko; Miyagawa, Kazuaki

doi:https://doi.org/10.1016/j.jcms.2025.07.021

Association between the timing of secondary alveolar bone grafting and maxillary permanent central incisor development in unilateral cleft lip and palate

Saka, Akihiro; Nishizawa, Chiaki; Matsushita, Yutaka et al.

Journal of Cranio-Maxillofacial Surgery, 2025, 53(10), 1795-1803

アクセス数:4件（2026-02-16 10:17 集計）

固定URL: https://hdl.handle.net/11094/103699

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タイトル	Association between the timing of secondary alveolar bone grafting and maxillary permanent central incisor development in unilateral cleft lip and palate
著者	著者名 Saka, Akihiro
	著者名 Nishizawa, Chiaki
	著者名 Matsushita, Yutaka
	NRID 1000000301804 1000000301804 著者名 Michigami, Toshimi
	NRID 1000000367541 1000000367541 ORCID 0000-0002-0306-3627 0000-0002-0306-3627 researchmap permalink mes5 mes5 Scopus Author ID 56395750500 56395750500 著者名 Tanaka, Susumu
	NRID 1000070397701 1000070397701 ORCID 0000-0002-7855-9600 0000-0002-7855-9600 researchmap permalink read0076452 read0076452 Scopus Author ID 55667115400 55667115400 著者名 Isomura, Emiko Tanaka
	NRID 1000020205371 1000020205371 ORCID 0000-0002-4556-2491 0000-0002-4556-2491 researchmap permalink 4321Kogo2 4321Kogo2 Scopus Author ID 7003762492 7003762492 著者名 Kogo, Mikihiko
	NRID 1000050635381 1000050635381 ORCID 0000-0003-4014-1847 0000-0003-4014-1847 researchmap permalink kaz-miyagawa kaz-miyagawa Scopus Author ID 37012083900 37012083900 著者名 Miyagawa, Kazuaki
キーワード等	Alveolar cleft patients
	Autogenous bone grafting
	Cone beam computed tomography
	Maxillary central incisors
	Tooth development
内容	Saka A., Nishizawa C., Matsushita Y., et al. Association between the timing of secondary alveolar bone grafting and maxillary permanent central incisor development in unilateral cleft lip and palate. Journal of Cranio-Maxillofacial Surgery 53, 1795 (2025); https://doi.org/10.1016/j.jcms.2025.07.021.
抄録	Secondary alveolar bone grafting (SABG) supports the eruption of impacted permanent teeth and the establishment of a proper dental arch in patients with cleft lip and palate (CLP) or cleft lip and alveolus (CLA). However, the optimal timing for SABG remains controversial. This retrospective study aimed to evaluate the developmental changes of the maxillary permanent central incisor (MPCI) following SABG in patients with unilateral CLP (UCLP), using cone-beam computed tomography (CBCT). CBCT scans were collected from 49 patients (aged 4–10 years) with UCLP before and 12 months after SABG. The positional change and axial angulation of the MPCI within the alveolar cleft were quantitatively assessed. The greatest change in displacement and angulation changes of the MPCI were observed in patients who underwent SABG between 4 and 7 years of age, regardless of postoperative orthodontic intervention. The early SABG (aged 4–7 years) group showed greater axial angulation changes compared to the late group (aged 8–10 years). These findings suggest that early SABG may facilitate bone bridge formation, thereby supporting the physiological development of the MPCI on the cleft side. CBCT evaluation may be a useful tool for guiding clinical research and optimizing surgical timing in patients with UCLP.
出版者	Churchill Livingstone
収録物名	Journal of Cranio-Maxillofacial Surgery
巻(号)	53(10)
ページ	1795-1803
刊行年月	2025-09-09
言語	英語
ハンドルURL	https://hdl.handle.net/11094/103699
PISSN	10105182
eISSN	18784119
関連情報 (isVersionOf)	DOI (出版社版) https://doi.org/10.1016/j.jcms.2025.07.021
アクセス権	embargoed access
権利情報	© 2025. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
権利情報	The full-text file will be made open to the public on 9 September 2026 in accordance with the publisher's policy.
出版タイプ	Accepted Manuscript
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of Cranio-Maxillofacial Surgery. 2025, 53(10), p. 1795-1803
DC.title	Association between the timing of secondary alveolar bone grafting and maxillary permanent central incisor development in unilateral cleft lip and palate
DC.creator	Saka, Akihiro
	Nishizawa, Chiaki
	Matsushita, Yutaka
	Michigami, Toshimi
	Tanaka, Susumu
	Isomura, Emiko Tanaka
	Kogo, Mikihiko
	Miyagawa, Kazuaki
DC.publisher	Churchill Livingstone
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2025-09-09
DC.identifier	https://doi.org/10.1016/j.jcms.2025.07.021
DC.subject	Alveolar cleft patients
	Autogenous bone grafting
	Cone beam computed tomography
	Maxillary central incisors
	Tooth development
DC.description	Saka A., Nishizawa C., Matsushita Y., et al. Association between the timing of secondary alveolar bone grafting and maxillary permanent central incisor development in unilateral cleft lip and palate. Journal of Cranio-Maxillofacial Surgery 53, 1795 (2025); https://doi.org/10.1016/j.jcms.2025.07.021.
DCTERMS.abstract	Secondary alveolar bone grafting (SABG) supports the eruption of impacted permanent teeth and the establishment of a proper dental arch in patients with cleft lip and palate (CLP) or cleft lip and alveolus (CLA). However, the optimal timing for SABG remains controversial. This retrospective study aimed to evaluate the developmental changes of the maxillary permanent central incisor (MPCI) following SABG in patients with unilateral CLP (UCLP), using cone-beam computed tomography (CBCT). CBCT scans were collected from 49 patients (aged 4–10 years) with UCLP before and 12 months after SABG. The positional change and axial angulation of the MPCI within the alveolar cleft were quantitatively assessed. The greatest change in displacement and angulation changes of the MPCI were observed in patients who underwent SABG between 4 and 7 years of age, regardless of postoperative orthodontic intervention. The early SABG (aged 4–7 years) group showed greater axial angulation changes compared to the late group (aged 8–10 years). These findings suggest that early SABG may facilitate bone bridge formation, thereby supporting the physiological development of the MPCI on the cleft side. CBCT evaluation may be a useful tool for guiding clinical research and optimizing surgical timing in patients with UCLP.
DC.rights	© 2025. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
DC.rights	The full-text file will be made open to the public on 9 September 2026 in accordance with the publisher's policy.
DC.format	103699
citation_title	Association between the timing of secondary alveolar bone grafting and maxillary permanent central incisor development in unilateral cleft lip and palate
citation_author	Saka, Akihiro
	Nishizawa, Chiaki
	Matsushita, Yutaka
	Michigami, Toshimi
	Tanaka, Susumu
	Isomura, Emiko Tanaka
	Kogo, Mikihiko
	Miyagawa, Kazuaki
citation_publisher	Churchill Livingstone
citation_language	英語
citation_date	2025-09-09
citation_journal_title	Journal of Cranio-Maxillofacial Surgery
citation_volume	53
citation_issue	10
citation_firstpage	1795
citation_lastpage	1803
citation_doi	https://doi.org/10.1016/j.jcms.2025.07.021
citation_public_url	https://hdl.handle.net/11094/103699

Association between the timing of secondary alveolar bone grafting and maxillary permanent central incisor development in unilateral cleft lip and palate

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