Comprehensive Mapping of Compositional Dynamics in the Formose Reaction Network

Nishijima, Hiroaki; Tabata, Hiro; Hase, Yoko et al.

Angewandte Chemie - International Edition, 2025, e25258

アクセス数:3件（2026-02-15 20:22 集計）

固定URL: https://hdl.handle.net/11094/103715

閲覧可能ファイル 

ファイル フォーマット 利用条件 サイズ 閲覧回数 利用開始日 説明 information
AngewChemIntEd_e25258 pdf なし 1.95 MB 7 2026.02.06  
Creative Commons : 表示 - 非営利 - 改変禁止

論文情報

ファイル出力 EndNote Basic出力 Mendeley出力

タイトル
Comprehensive Mapping of Compositional Dynamics in the Formose Reaction Network
著者
ORCID
0000-0002-5902-6104 0000-0002-5902-6104
Scopus Author ID
57861375500 57861375500
著者名
Nishijima, Hiroaki
ORCID
0000-0001-8137-9136 0000-0001-8137-9136
Scopus Author ID
57216761264 57216761264
著者名
Tabata, Hiro
著者名
Hase, Yoko
著者名
Miyake, Rika
著者名
Nakanishi, Shuji
キーワード等
Carbohydrates
Chemical reaction network
Formose reaction
Mass spectrometry
Systems chemistry
内容
Nishijima H., Tabata H., Hase Y., et al. Comprehensive Mapping of Compositional Dynamics in the Formose Reaction Network. Angewandte Chemie - International Edition, e25258 (2025); https://doi.org/10.1002/anie.202525258.
抄録
A chemical reaction network (CRN) can generate complex molecules from simple starting materials through multiple interconnected reactions. The formose reaction, which produces monosaccharides from formaldehyde (HCHO), is a prototypical non-enzymatic CRN. Although more than half of the feedstock in this reaction is converted into non-target products (products other than the target monosaccharides), traditionally referred to as “tar,” the compositional evolution of these products has remained unexplored. In this study, we visualized the formose reaction's compositional landscape (target and non-target products) by applying van Krevelen (VK) diagrams and Kendrick mass defect (KMD) plots using data from high-resolution mass spectrometry, enabling comprehensive visualization of the products' composition without structural identification of individual compounds. Under NaOH catalysis, various side reactions proceeded with low selectivity, leading to a wide variety of non-target products, whereas under Ca(OH)₂ catalysis, dehydration-type side reactions became predominant in the later stages. These findings reveal that the product distribution in the formose reaction is highly catalyst- and stage-dependent. The developed visualization framework provides a powerful tool for understanding complex CRNs and suggests rational strategies for reaction control, such as suppressing dehydration to improve the yield of target products in the presence of Ca(OH)₂ catalyst.
出版者
John Wiley and Sons Inc
収録物名
Angewandte Chemie - International Edition
ページ
e25258
刊行年月
2025-12-27
言語
英語
ハンドルURL
https://hdl.handle.net/11094/103715
PISSN
14337851
eISSN
15213773
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1002/anie.202525258
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article