Association Between Myristic Acid in Plasma Triglycerides and Metabolic Dysfunction–Associated Steatotic Liver Disease in Patients With Type 2 Diabetes: A Comprehensive Analysis of Plasma Lipids Using Supercritical Fluid Chromatography–Tandem Mass Spectrometry

Hosoe, Shigero; Katakami, Naoto; Taya, Naohiro et al.

Diabetes, 2025, 74(10), 1839-1849

アクセス数:172件（2026-04-04 14:28 集計）

固定URL: https://hdl.handle.net/11094/103801

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タイトル
Association Between Myristic Acid in Plasma Triglycerides and Metabolic Dysfunction–Associated Steatotic Liver Disease in Patients With Type 2 Diabetes: A Comprehensive Analysis of Plasma Lipids Using Supercritical Fluid Chromatography–Tandem Mass Spectrometry
著者
著者名
Hosoe, Shigero
NRID
1000010403049 1000010403049
ORCID
0000-0001-9020-8320 0000-0001-9020-8320
researchmap permalink
naoto.katakami naoto.katakami
Scopus Author ID
7003392840 7003392840
著者名
Katakami, Naoto
NRID
1000000991225 1000000991225
researchmap permalink
n-taya n-taya
Scopus Author ID
57208973904 57208973904
著者名
Taya, Naohiro
著者名
Omori, Kazuo
NRID
1000000751067 1000000751067
researchmap permalink
takahara-mitsuyoshi takahara-mitsuyoshi
Scopus Author ID
35933605700 35933605700
著者名
Takahara, Mitsuyoshi
著者名
Konya, Yutaka
著者名
Obara, Sachiko
著者名
Hidaka, Ayako
著者名
Nakao, Motonao
NRID
1000030844419 1000030844419
著者名
Takahashi, Masatomo
NRID
1000070622166 1000070622166
ORCID
0000-0003-4608-4652 0000-0003-4608-4652
researchmap permalink
izumi_yoshihiro izumi_yoshihiro
Scopus Author ID
49561344400 49561344400
著者名
Izumi, Yoshihiro
NRID
1000010432444 1000010432444
著者名
Bamba, Takeshi
NRID
1000060346145 1000060346145
ORCID
0000-0002-0851-9603 0000-0002-0851-9603
researchmap permalink
shimomura_i shimomura_i
Scopus Author ID
7006715546 7006715546
著者名
Shimomura, Iichiro
内容
Hosoe S., Katakami N., Taya N., et al. Association Between Myristic Acid in Plasma Triglycerides and Metabolic Dysfunction–Associated Steatotic Liver Disease in Patients With Type 2 Diabetes: A Comprehensive Analysis of Plasma Lipids Using Supercritical Fluid Chromatography–Tandem Mass Spectrometry. Diabetes 74, 1839 (2025); https://doi.org/10.2337/db25-0099.
抄録
This study aimed to investigate the relationship between the plasma lipidome and metabolic dysfunction– associated steatotic liver disease (MASLD) in type 2 diabetes. Initially, we conducted a plasma lipidome analysis using supercritical fluid chromatography–tandem mass spectrometry in 143 patients with type 2 diabetes with and without MASLD. Of the 349 lipid species identified, 13 had higher levels and a fold-change ≥2 in the MASLD group than in the non-MASLD group; 10 of these 13 lipids were triglycerides (TGs). The constituent fatty acid (FA) in TGs that exhibited the greatest difference between patients with and without MASLD was myristic acid (FA 14:0). The presence of MASLD was an independent explanatory factor for high FA 14:0 levels in TGs, even after adjusting for covariates. Next, we assessed whether the levels of lipids identified in the initial analysis were influenced by comprehensive diabetes treatment in 26 patients. After comprehensive diabetes treatment of 2 weeks, FA levels in many TGs significantly decreased; especially FA 14:0 levels, and this reduction was more pronounced in patients with MASLD. These results suggest that various plasma lipids, particularly TGs comprising FA 14:0, may be associated with the pathogenesis of MASLD in patients with type 2 diabetes.
出版者
American Diabetes Association Inc.
収録物名
Diabetes
巻(号)
74(10)
ページ
1839-1849
刊行年月
2025-08-14
言語
英語
ハンドルURL
https://hdl.handle.net/11094/103801
PISSN
00121797
eISSN
1939327X
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.2337/db25-0099
アクセス権
open access
権利情報
© 2025 by the American Diabetes Association
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article