UV-A Radiation Impairs Sebaceous-Gland-Related Skin Barrier Function by Inducing Inflammation and Altering Intracellular Sebum-Like Lipid Composition

Dong, Wangyue; Kono, Maori; Takaishi, Masayuki et al.

Journal of Cosmetic Dermatology, 2025, 24(10), e70392

アクセス数:17件（2026-04-05 16:08 集計）

固定URL: https://hdl.handle.net/11094/103883

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タイトル
UV-A Radiation Impairs Sebaceous-Gland-Related Skin Barrier Function by Inducing Inflammation and Altering Intracellular Sebum-Like Lipid Composition
著者
著者名
Dong, Wangyue
NRID
1000060880995 1000060880995
ORCID
0009-0004-9821-9656 0009-0004-9821-9656
researchmap permalink
_maori _maori
著者名
Kono, Maori
NRID
1000020898225 1000020898225
researchmap permalink
takaishim takaishim
Scopus Author ID
55503143300 55503143300
著者名
Takaishi, Masayuki
著者名
Kyuka, Ayumi
NRID
1000070749994 1000070749994
ORCID
0000-0002-2618-5539 0000-0002-2618-5539
researchmap permalink
hirokokato hirokokato
Scopus Author ID
55314208200 55314208200
著者名
Kato, Hiroko
NRID
1000070600097 1000070600097
researchmap permalink
fufufufu fufufufu
著者名
Fujita, Fumitaka
キーワード等
inflammation
sebaceous glands
sebocytes
sebum
skin barrier
UV-A
内容
Dong W., Kono M., Takaishi M., et al. UV-A Radiation Impairs Sebaceous-Gland-Related Skin Barrier Function by Inducing Inflammation and Altering Intracellular Sebum-Like Lipid Composition. Journal of Cosmetic Dermatology 24, e70392 (2025); https://doi.org/10.1111/jocd.70392.
抄録
Background: Sebaceous glands (SGs) secrete sebum to form a protective barrier that maintains skin health. However, exposure to ultraviolet A (UV-A) radiation damages the skin barrier, leading to dryness and inflammation. Aims: In this study, we investigated how UV-A radiation alters SG function, focusing on inflammation and changes in the composition of intracellular sebum-like lipids. We also explored the role of SG-related mechanisms in UVA-radiation-induced skin barrier damage. Methods: Human primary sebocytes were cultured from SGs isolated from human skin samples and exposed to different doses of UV-A radiation. Inflammatory cytokines released into the culture medium were measured, followed by gene expression analysis using mRNA extracted from cells to examine specific target genes. Intracellular sebum-like lipid composition was analyzed using liquid chromatography–tandem mass spectrometry, and skin barrier function was evaluated using a three-dimensional reconstructed human epidermis (3D skin) model. Results: UV-A irradiation increased inflammatory cytokine levels in the culture medium and altered the expression levels of several genes. Intracellular sebum-like lipid composition was also modified following UV-A irradiation, with notable sex differences. Furthermore, the skin barrier function was impaired in 3D skin models cultured with the supernatant from UV-A-irradiated sebocyte cultures. Conclusions: This study demonstrated that UV-A radiation stimulated sebocytes to release inflammatory cytokines and altered gene expression. Additionally, UV-A irradiation modified the intracellular sebum-like lipid composition in a sex-dependent manner, contributing to skin barrier damage.
出版者
John Wiley and Sons Inc
収録物名
Journal of Cosmetic Dermatology
巻(号)
24(10)
ページ
e70392
刊行年月
2025-10-10
言語
英語
ハンドルURL
https://hdl.handle.net/11094/103883
PISSN
14732130
eISSN
14732165
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1111/jocd.70392
アクセス権
open access
権利情報
This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article