A VITA Index for predicting cytocompatibility of metallic biomaterials based on ion release and toxicity

Matsuzaka, Tadaaki; Matsugaki, Aira; Nakano, Takayoshi

doi:https://doi.org/10.1016/j.biomaterials.2026.124101

A VITA Index for predicting cytocompatibility of metallic biomaterials based on ion release and toxicity

Matsuzaka, Tadaaki; Matsugaki, Aira; Nakano, Takayoshi

Biomaterials, 2026, 331, 124101

アクセス数:1件（2026-05-27 04:15 集計）

固定URL: https://hdl.handle.net/11094/104833

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タイトル	A VITA Index for predicting cytocompatibility of metallic biomaterials based on ion release and toxicity
著者	NRID 1000001019109 1000001019109 ORCID 0000-0002-6215-2873 0000-0002-6215-2873 researchmap permalink tadaaki_matsuzaka tadaaki_matsuzaka Scopus Author ID 57218552928 57218552928 著者名 Matsuzaka, Tadaaki
	NRID 1000010592529 1000010592529 ORCID 0000-0002-8427-7124 0000-0002-8427-7124 researchmap permalink aira aira Scopus Author ID 24172720900 24172720900 著者名 Matsugaki, Aira
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 著者名 Nakano, Takayoshi
キーワード等	Biomedical alloys design
	Corrosion behavior
	In vitrocytocompatibility
	Metal ion toxicity
	Osteoblast response
	VITA Index (Velocity–Ion Toxicity–Affinity)
内容	Matsuzaka T., Matsugaki A., Nakano T.. A VITA Index for predicting cytocompatibility of metallic biomaterials based on ion release and toxicity. Biomaterials 331, 124101 (2026); https://doi.org/10.1016/j.biomaterials.2026.124101.
抄録	Biocompatibility and cytocompatibility are critical early considerations in the development of metallic biomaterials for implantable devices; however, conventional in vitro cytotoxicity evaluations typically assess corrosion behavior or cytotoxicity independently and fail to account for their coupled effects on metal-ion release–driven cytocompatibility. Here, we present a novel Velocity–Ion Toxicity–Affinity (VITA) Index—a quantitative and mechanistically informed framework that integrates electrochemical dissolution (corrosion) behavior with ion-specific cytotoxicity to evaluate in vitro biocompatibility governed by metal-ion release. By combining corrosion profiling with cell-based cytocompatibility assays (using osteoblasts and fibroblasts as a representative model), the VITA Index demonstrates first-order accuracy, capturing robust correlations between ion-release kinetics and cell viability across both established biomedical alloys and emerging materials, including high-entropy alloys. The VITA Index enables rapid and mechanistically informed screening of candidate metallic biomaterials and provides a practical framework for in vitro biocompatibility assessment, cytotoxicity prediction, and data-driven alloy design for future implant applications.
出版者	Elsevier Ltd
収録物名	Biomaterials
巻(号)	331
ページ	124101
刊行年月	2026-03-14
言語	英語
ハンドルURL	https://hdl.handle.net/11094/104833
PISSN	01429612
eISSN	18785905
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.biomaterials.2026.124101
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Biomaterials. 2026, 331, p. 124101
DC.title	A VITA Index for predicting cytocompatibility of metallic biomaterials based on ion release and toxicity
DC.creator	Matsuzaka, Tadaaki
	Matsugaki, Aira
	Nakano, Takayoshi
DC.publisher	Elsevier Ltd
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2026-03-14
DC.identifier	https://doi.org/10.1016/j.biomaterials.2026.124101
DC.subject	Biomedical alloys design
	Corrosion behavior
	In vitrocytocompatibility
	Metal ion toxicity
	Osteoblast response
	VITA Index (Velocity–Ion Toxicity–Affinity)
DC.description	Matsuzaka T., Matsugaki A., Nakano T.. A VITA Index for predicting cytocompatibility of metallic biomaterials based on ion release and toxicity. Biomaterials 331, 124101 (2026); https://doi.org/10.1016/j.biomaterials.2026.124101.
DCTERMS.abstract	Biocompatibility and cytocompatibility are critical early considerations in the development of metallic biomaterials for implantable devices; however, conventional in vitro cytotoxicity evaluations typically assess corrosion behavior or cytotoxicity independently and fail to account for their coupled effects on metal-ion release–driven cytocompatibility. Here, we present a novel Velocity–Ion Toxicity–Affinity (VITA) Index—a quantitative and mechanistically informed framework that integrates electrochemical dissolution (corrosion) behavior with ion-specific cytotoxicity to evaluate in vitro biocompatibility governed by metal-ion release. By combining corrosion profiling with cell-based cytocompatibility assays (using osteoblasts and fibroblasts as a representative model), the VITA Index demonstrates first-order accuracy, capturing robust correlations between ion-release kinetics and cell viability across both established biomedical alloys and emerging materials, including high-entropy alloys. The VITA Index enables rapid and mechanistically informed screening of candidate metallic biomaterials and provides a practical framework for in vitro biocompatibility assessment, cytotoxicity prediction, and data-driven alloy design for future implant applications.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	104833
citation_title	A VITA Index for predicting cytocompatibility of metallic biomaterials based on ion release and toxicity
citation_author	Matsuzaka, Tadaaki
	Matsugaki, Aira
	Nakano, Takayoshi
citation_publisher	Elsevier Ltd
citation_language	英語
citation_date	2026-03-14
citation_journal_title	Biomaterials
citation_volume	331
citation_firstpage	124101
citation_doi	https://doi.org/10.1016/j.biomaterials.2026.124101
citation_public_url	https://hdl.handle.net/11094/104833

A VITA Index for predicting cytocompatibility of metallic biomaterials based on ion release and toxicity

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