Enhancement of Cell Adhesion on 3D-Printed PLA through Surface Modification Using Photoactivated Chlorine Dioxide

Otsuka, Nana; Yagura, Yasuo; Inoue, Tsuyoshi et al.

ACS Applied Bio Materials, 2026, 9(11), 4792-4802

アクセス数:112件（2026-08-27 18:18 集計）

固定URL: https://hdl.handle.net/11094/105202

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論文情報

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タイトル
Enhancement of Cell Adhesion on 3D-Printed PLA through Surface Modification Using Photoactivated Chlorine Dioxide
著者
著者名
Otsuka, Nana
著者名
Yagura, Yasuo
NRID
1000020263204 1000020263204
ORCID
0000-0001-5337-5066 0000-0001-5337-5066
researchmap permalink
read0185256 read0185256
Scopus Author ID
7501390753 7501390753
著者名
Inoue, Tsuyoshi
NRID
1000070354264 1000070354264
著者名
Taguchi, Tetsushi
NRID
1000010784944 1000010784944
著者名
Nishiguchi, Akihiro
NRID
1000020632318 1000020632318
ORCID
0000-0002-1808-7373 0000-0002-1808-7373
researchmap permalink
pikurin3 pikurin3
Scopus Author ID
8856988200 8856988200
著者名
Asahara, Haruyasu
キーワード等
3D-printed scaffolds
carboxy functionalization
cell adhesion
photo-oxidation
polylactic acid (PLA)
surface charge density
内容
Otsuka N., Yagura Y., Inoue T., et al. Enhancement of Cell Adhesion on 3D-Printed PLA through Surface Modification Using Photoactivated Chlorine Dioxide. ACS Applied Bio Materials 9(11), 4792–4802 (2026); https://doi.org/10.1021/acsabm.5c02452.
抄録
Poly(lactic acid) (PLA) has attracted considerable attention as a scaffold material in tissue engineering because of its biocompatibility, biodegradability, and suitable mechanical strength. However, PLA’s inherent hydrophobicity limits its cell affinity. To address this limitation, several surface modification strategies have been developed; nevertheless, challenges remain, including reduced mechanical strength, limited applicability to three-dimensional structures, and procedural complexity. In response, a surface modification method, termed “photo-oxidation”, was developed. This method utilizes reactive species generated by light irradiation of chlorine dioxide radicals and overcomes the aforementioned challenges. In this study, PLA was oxidized using the photo-oxidation method, and its cell affinity was evaluated using mouse fibroblasts (L929 cells). The results showed that photo-oxidation at an appropriate temperature significantly enhanced cell affinity, as evidenced by increased cell numbers and pronounced actin extension. Furthermore, this method was successfully applied to three-dimensional structures, demonstrating its potential as a versatile strategy for improving the biological performance of PLA.
出版者
American Chemical Society
収録物名
ACS Applied Bio Materials
巻(号)
9(11)
ページ
4792-4802
刊行年月
2026-05-15
言語
英語
ハンドルURL
https://hdl.handle.net/11094/105202
eISSN
25766422
関連情報 (isVersionOf)
DOI (出版社版)
https://doi.org/10.1021/acsabm.5c02452
アクセス権
open access
権利情報
This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in ACS Applied Bio Materials, copyright © American Chemical Society after peer review. To access the final edited and published work see https://doi.org/10.1021/acsabm.5c02452.
出版タイプ
Author’s Original
カテゴリ
学術雑誌論文 Journal Article