Diagnostic impact of interpretation criteria for [¹⁸F]PSMA-1007 PET/CT: Prospective comparison with CT and bone scan

Liu, Yuwei; Hatano, Koji; Uemura, Motohide; Hirata, Takero; Naka, Sadahiro; Kurimoto, Kenta; Sasaki, Hidetaka; Kamiya, Takashi; Aihara, Ryo; Ding, Feier; Cardinale, Jens; Giesel, Frederik L.; Werner, Rudolf A.; Katayama, Daisuke; Kato, Hiroki; Isohashi, Kayako; Tomiyama, Noriyuki; Nonomura, Norio; Watabe, Tadashi

doi:https://doi.org/10.1007/s00259-026-07931-1

Diagnostic impact of interpretation criteria for [¹⁸F]PSMA-1007 PET/CT: Prospective comparison with CT and bone scan

Liu, Yuwei; Hatano, Koji; Uemura, Motohide et al.

European Journal of Nuclear Medicine and Molecular Imaging, 2026

アクセス数:545件（2026-09-29 08:32 集計）

固定URL: https://hdl.handle.net/11094/105900

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タイトル	Diagnostic impact of interpretation criteria for [¹⁸F]PSMA-1007 PET/CT: Prospective comparison with CT and bone scan
著者	ORCID 0000-0003-0762-9840 0000-0003-0762-9840 Scopus Author ID 57209179470 57209179470 著者名 Liu, Yuwei
	NRID 1000060762234 1000060762234 ORCID 0000-0002-8409-5152 0000-0002-8409-5152 researchmap permalink koji_hatano koji_hatano Scopus Author ID 14627167600 14627167600 著者名 Hatano, Koji
	NRID 1000040631015 1000040631015 researchmap permalink urourouro urourouro 著者名 Uemura, Motohide
	NRID 1000020777916 1000020777916 researchmap permalink HirataTakero HirataTakero Scopus Author ID 56485165100 56485165100 著者名 Hirata, Takero
	NRID 1000060599843 1000060599843 researchmap permalink _sada_ _sada_ 著者名 Naka, Sadahiro
	NRID 1000070868968 1000070868968 researchmap permalink kentakuri kentakuri Scopus Author ID 57223821707 57223821707 著者名 Kurimoto, Kenta
	NRID 1000010738628 1000010738628 ORCID 0009-0003-6630-3784 0009-0003-6630-3784 著者名 Sasaki, Hidetaka
	NRID 1000080550764 1000080550764 ORCID 0000-0002-6699-8796 0000-0002-6699-8796 Scopus Author ID 57202820345 57202820345 著者名 Kamiya, Takashi
	著者名 Aihara, Ryo
	著者名 Ding, Feier
	著者名 Cardinale, Jens
	著者名 Giesel, Frederik L.
	著者名 Werner, Rudolf A.
	researchmap permalink daisuke_katayama daisuke_katayama 著者名 Katayama, Daisuke
	NRID 1000020448054 1000020448054 ORCID 0000-0003-0838-6772 0000-0003-0838-6772 researchmap permalink kato-h kato-h Scopus Author ID 55585587900 55585587900 著者名 Kato, Hiroki
	NRID 1000050598604 1000050598604 ORCID 0000-0002-2081-3020 0000-0002-2081-3020 researchmap permalink researchmap5849 researchmap5849 Scopus Author ID 6505990065 6505990065 著者名 Isohashi, Kayako
	NRID 1000050294070 1000050294070 ORCID 0000-0001-9918-7327 0000-0001-9918-7327 researchmap permalink 3430 3430 Scopus Author ID 7006024942 7006024942 著者名 Tomiyama, Noriyuki
	NRID 1000030263263 1000030263263 researchmap permalink read0185096 read0185096 Scopus Author ID 7005880662 7005880662 著者名 Nonomura, Norio
	NRID 1000090648932 1000090648932 ORCID 0000-0001-8658-2395 0000-0001-8658-2395 researchmap permalink twosaka2018 twosaka2018 Scopus Author ID 57421862900 57421862900 著者名 Watabe, Tadashi
キーワード等	PET/CT
	Positivity threshold
	Prostate cancer
	PSMA-RADS
	[¹⁸F]PSMA-1007
内容	Liu Y., Hatano K., Uemura M., et al. Diagnostic impact of interpretation criteria for [¹⁸F]PSMA-1007 PET/CT: Prospective comparison with CT and bone scan. European Journal of Nuclear Medicine and Molecular Imaging (2026); https://doi.org/10.1007/s00259-026-07931-1.
抄録	Purpose: The PSMA Reporting and Data System (PSMA-RADS) has been proposed to standardize the interpretation of PSMA-PET. However, its diagnostic performance has not been fully validated. This study aimed to determine the optimal interpretation criteria for PSMA-PET and to compare its diagnostic performance with conventional imaging. Methods: This prospective study enrolled 284 patients across various disease stages who underwent [¹⁸F]PSMA-1007 PET/CT. Diagnostic performance was evaluated using different positivity thresholds based on PSMA-RADS categories, PSMA-expression scores, and SUVmax, and was compared with that of CT and bone scan (BS). True-positive rates were summarized across PSMA-RADS categories. Results: A total of 771 lesions were analyzed. PSMA-RADS demonstrated superior diagnostic performance compared with other interpretation criteria. Using PSMA-RADS-4 as the positivity threshold, [¹⁸F]PSMA-1007 PET/CT achieved a sensitivity of 78.5% and a specificity of 95.3%. PSMA-RADS-3 increased sensitivity to 98.4% but reduced specificity to 58.8%. PSMA-expression score 2 yielded a sensitivity of 52.2% and a specificity of 99.3%, whereas SUVmax cutoff of 5.7 yielded a sensitivity of 72.6% and a specificity of 85.8%. When PSMA-RADS-4 was used as the positivity threshold, PET/CT showed higher sensitivity than CT (81.3% vs. 48.6%) and BS (84.5% vs. 65.7%), as well as higher accuracy (83.2% vs. 56.2% and 87.6% vs. 74.5%, respectively). The true-positive rate of PSMA-RADS-3 lesions was 69.7%, which was substantially lower than that of PSMA-RADS-4 lesions (96.7%). Conclusion: PSMA-RADS-4 represents an optimal positivity threshold for [¹⁸F]PSMA-1007 PET/CT, providing superior diagnostic performance compared with CT and BS and supporting its clinical utility for standardized image interpretation.
出版者	Springer
収録物名	European Journal of Nuclear Medicine and Molecular Imaging
刊行年月	2026-05-22
言語	英語
ハンドルURL	https://hdl.handle.net/11094/105900
PISSN	16197070
eISSN	16197089
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1007/s00259-026-07931-1
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	European Journal of Nuclear Medicine and Molecular Imaging. 2026
DC.title	Diagnostic impact of interpretation criteria for [¹⁸F]PSMA-1007 PET/CT: Prospective comparison with CT and bone scan
DC.creator	Liu, Yuwei
	Hatano, Koji
	Uemura, Motohide
	Hirata, Takero
	Naka, Sadahiro
	Kurimoto, Kenta
	Sasaki, Hidetaka
	Kamiya, Takashi
	Aihara, Ryo
	Ding, Feier
	Cardinale, Jens
	Giesel, Frederik L.
	Werner, Rudolf A.
	Katayama, Daisuke
	Kato, Hiroki
	Isohashi, Kayako
	Tomiyama, Noriyuki
	Nonomura, Norio
	Watabe, Tadashi
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2026-05-22
DC.identifier	https://doi.org/10.1007/s00259-026-07931-1
DC.subject	PET/CT
	Positivity threshold
	Prostate cancer
	PSMA-RADS
	[¹⁸F]PSMA-1007
DC.description	Liu Y., Hatano K., Uemura M., et al. Diagnostic impact of interpretation criteria for [¹⁸F]PSMA-1007 PET/CT: Prospective comparison with CT and bone scan. European Journal of Nuclear Medicine and Molecular Imaging (2026); https://doi.org/10.1007/s00259-026-07931-1.
DCTERMS.abstract	Purpose: The PSMA Reporting and Data System (PSMA-RADS) has been proposed to standardize the interpretation of PSMA-PET. However, its diagnostic performance has not been fully validated. This study aimed to determine the optimal interpretation criteria for PSMA-PET and to compare its diagnostic performance with conventional imaging. Methods: This prospective study enrolled 284 patients across various disease stages who underwent [¹⁸F]PSMA-1007 PET/CT. Diagnostic performance was evaluated using different positivity thresholds based on PSMA-RADS categories, PSMA-expression scores, and SUVmax, and was compared with that of CT and bone scan (BS). True-positive rates were summarized across PSMA-RADS categories. Results: A total of 771 lesions were analyzed. PSMA-RADS demonstrated superior diagnostic performance compared with other interpretation criteria. Using PSMA-RADS-4 as the positivity threshold, [¹⁸F]PSMA-1007 PET/CT achieved a sensitivity of 78.5% and a specificity of 95.3%. PSMA-RADS-3 increased sensitivity to 98.4% but reduced specificity to 58.8%. PSMA-expression score 2 yielded a sensitivity of 52.2% and a specificity of 99.3%, whereas SUVmax cutoff of 5.7 yielded a sensitivity of 72.6% and a specificity of 85.8%. When PSMA-RADS-4 was used as the positivity threshold, PET/CT showed higher sensitivity than CT (81.3% vs. 48.6%) and BS (84.5% vs. 65.7%), as well as higher accuracy (83.2% vs. 56.2% and 87.6% vs. 74.5%, respectively). The true-positive rate of PSMA-RADS-3 lesions was 69.7%, which was substantially lower than that of PSMA-RADS-4 lesions (96.7%). Conclusion: PSMA-RADS-4 represents an optimal positivity threshold for [¹⁸F]PSMA-1007 PET/CT, providing superior diagnostic performance compared with CT and BS and supporting its clinical utility for standardized image interpretation.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	105900
citation_title	Diagnostic impact of interpretation criteria for [¹⁸F]PSMA-1007 PET/CT: Prospective comparison with CT and bone scan
citation_author	Liu, Yuwei
	Hatano, Koji
	Uemura, Motohide
	Hirata, Takero
	Naka, Sadahiro
	Kurimoto, Kenta
	Sasaki, Hidetaka
	Kamiya, Takashi
	Aihara, Ryo
	Ding, Feier
	Cardinale, Jens
	Giesel, Frederik L.
	Werner, Rudolf A.
	Katayama, Daisuke
	Kato, Hiroki
	Isohashi, Kayako
	Tomiyama, Noriyuki
	Nonomura, Norio
	Watabe, Tadashi
citation_publisher	Springer
citation_language	英語
citation_date	2026-05-22
citation_journal_title	European Journal of Nuclear Medicine and Molecular Imaging
citation_doi	https://doi.org/10.1007/s00259-026-07931-1
citation_public_url	https://hdl.handle.net/11094/105900

Diagnostic impact of interpretation criteria for [¹⁸F]PSMA-1007 PET/CT: Prospective comparison with CT and bone scan

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