A Homology-Based Application to Diagnose Colorectal Adenoma and Early-Stage Cancer

Yokoyama, Yuhki; Kanayama, Kazuki; Matsuda, Miwa; Hatori, Nobuaki; Asano, Taiki; Morii, Eiichi; Yamamoto, Hirofumi; Nakane, Kazuaki

doi:https://doi.org/10.1111/pin.70143

A Homology-Based Application to Diagnose Colorectal Adenoma and Early-Stage Cancer

Yokoyama, Yuhki; Kanayama, Kazuki; Matsuda, Miwa et al.

Pathology International, 2026, 76(6), e70143

アクセス数:251件（2026-09-29 07:20 集計）

固定URL: https://hdl.handle.net/11094/106002

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タイトル	A Homology-Based Application to Diagnose Colorectal Adenoma and Early-Stage Cancer
著者	NRID 1000060615714 1000060615714 ORCID 0000-0002-8542-8588 0000-0002-8542-8588 researchmap permalink yyoko yyoko Scopus Author ID 53265530200 53265530200 著者名 Yokoyama, Yuhki
	NRID 1000020605943 1000020605943 著者名 Kanayama, Kazuki
	NRID 1000050880241 1000050880241 著者名 Matsuda, Miwa
	著者名 Hatori, Nobuaki
	著者名 Asano, Taiki
	NRID 1000010283772 1000010283772 ORCID 0000-0001-8490-3650 0000-0001-8490-3650 researchmap permalink read0046454 read0046454 Scopus Author ID 7003914326 7003914326 著者名 Morii, Eiichi
	NRID 1000030322184 1000030322184 researchmap permalink kobunyam kobunyam Scopus Author ID 12805320700 12805320700 著者名 Yamamoto, Hirofumi
	著者名 Nakane, Kazuaki
キーワード等	adenoma
	colorectum
	early-stage cancer
	homology
内容	Yokoyama Y., Kanayama K., Matsuda M., et al. A Homology-Based Application to Diagnose Colorectal Adenoma and Early-Stage Cancer. Pathology International 76, e70143 (2026); https://doi.org/10.1111/pin.70143.
抄録	Homology is a mathematical concept involving two Betti numbers—b0, representing the number of independent objects, and b1, representing the number of holes formed by surrounding objects—which can be used to quantify the contact degree. We previously demonstrated the use of a homology-based method to diagnose advanced colorectal cancer. It is clinically important to discriminate adenoma, especially high-grade adenoma, and early-stage cancer from non-cancerous tissue; thus, it was of interest to evaluate whether our homology-based method could also diagnose adenoma and early-stage cancer. In the present study, we developed a homology-based application to calculate b1 values for a region of interest, and used it to analyze normal tissue, adenoma, and early-stage cancer from the colorectum. Area correction was required for proper comparison of b1 values. We found that area-corrected b1 values were significantly higher in high-grade adenoma and early-stage cancer, compared to normal tissue. Although there remains a need for further development of the algorithm to discriminate low-grade adenoma and inflammatory regions, our present findings indicate that our homology-based method using Betti numbers can be useful for distinguishing high-grade adenoma and early-stage cancer from normal tissue, as well as advanced colorectal cancer.
出版者	John Wiley and Sons Inc
収録物名	Pathology International
巻(号)	76(6)
ページ	e70143
刊行年月	2026-06-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/106002
PISSN	13205463
eISSN	14401827
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1111/pin.70143
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Pathology International. 2026, 76(6), p. e70143
DC.title	A Homology-Based Application to Diagnose Colorectal Adenoma and Early-Stage Cancer
DC.creator	Yokoyama, Yuhki
	Kanayama, Kazuki
	Matsuda, Miwa
	Hatori, Nobuaki
	Asano, Taiki
	Morii, Eiichi
	Yamamoto, Hirofumi
	Nakane, Kazuaki
DC.publisher	John Wiley and Sons Inc
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2026-06-01
DC.identifier	https://doi.org/10.1111/pin.70143
DC.subject	adenoma
	colorectum
	early-stage cancer
	homology
DC.description	Yokoyama Y., Kanayama K., Matsuda M., et al. A Homology-Based Application to Diagnose Colorectal Adenoma and Early-Stage Cancer. Pathology International 76, e70143 (2026); https://doi.org/10.1111/pin.70143.
DCTERMS.abstract	Homology is a mathematical concept involving two Betti numbers—b0, representing the number of independent objects, and b1, representing the number of holes formed by surrounding objects—which can be used to quantify the contact degree. We previously demonstrated the use of a homology-based method to diagnose advanced colorectal cancer. It is clinically important to discriminate adenoma, especially high-grade adenoma, and early-stage cancer from non-cancerous tissue; thus, it was of interest to evaluate whether our homology-based method could also diagnose adenoma and early-stage cancer. In the present study, we developed a homology-based application to calculate b1 values for a region of interest, and used it to analyze normal tissue, adenoma, and early-stage cancer from the colorectum. Area correction was required for proper comparison of b1 values. We found that area-corrected b1 values were significantly higher in high-grade adenoma and early-stage cancer, compared to normal tissue. Although there remains a need for further development of the algorithm to discriminate low-grade adenoma and inflammatory regions, our present findings indicate that our homology-based method using Betti numbers can be useful for distinguishing high-grade adenoma and early-stage cancer from normal tissue, as well as advanced colorectal cancer.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	106002
citation_title	A Homology-Based Application to Diagnose Colorectal Adenoma and Early-Stage Cancer
citation_author	Yokoyama, Yuhki
	Kanayama, Kazuki
	Matsuda, Miwa
	Hatori, Nobuaki
	Asano, Taiki
	Morii, Eiichi
	Yamamoto, Hirofumi
	Nakane, Kazuaki
citation_publisher	John Wiley and Sons Inc
citation_language	英語
citation_date	2026-06-01
citation_journal_title	Pathology International
citation_volume	76
citation_issue	6
citation_firstpage	e70143
citation_doi	https://doi.org/10.1111/pin.70143
citation_public_url	https://hdl.handle.net/11094/106002

A Homology-Based Application to Diagnose Colorectal Adenoma and Early-Stage Cancer

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