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https://doi.org/10.1083/jcb.131.6.1789
このアイテムへのリンクには次のURLをご利用ください:http://hdl.handle.net/11094/23087
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論文情報
タイトル
Synapsin I Deficiency Results in the Structural Change in the Presynaptic Terminals in the Murine Nervous System
著者
Takei, Yosuke
Takei, Yosuke
Harada, Akihiro
Harada, Akihiro
Takeda, Sen
Takeda, Sen
Kobayashi, Katsunori
Kobayashi, Katsunori
Terada, Sumio
Terada, Sumio
Noda, Tetsuo
Noda, Tetsuo
Takahashi, Tomoyuki
Takahashi, Tomoyuki
Hirokawa, Nobutaka
Hirokawa, Nobutaka
抄録
Synapsin I is one of the major synaptic vesicle-associated proteins. Previous experiments implicated its crucial role in synaptogenesis and transmitter release. To better define the role of synapsin I in vivo, we used gene targeting to disrupt the murine synapsin I gene. Mutant mice lacking synapsin I appeared to develop normally and did not have gross anatomical abnormalities. However, when we examined the presynaptic structure of the hippocampal CA3 field in detail, we found that the sizes of mossy fiber giant terminals were significantly smaller, the number of synaptic vesicles became reduced, and the presynaptic structures altered, although the mossy fiber long-term potentiation remained intact. These results suggest significant contribution of synapsin I to the formation and maintenance of the presynaptic structure.
公開者
The Rockefeller University Press
掲載誌名
Journal of Cell Biology
巻
131
号
6
開始ページ
1789
終了ページ
1800
刊行年月
1995-11-15
ISSN
00219525
NCID
AA00694812
DOI
info:doi/10.1083/jcb.131.6.1789
URL
http://hdl.handle.net/11094/23087
言語
英語
カテゴリ
学術雑誌論文 Journal Article
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著者版フラグ
publisher
NII資源タイプ
学術雑誌論文
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学術雑誌論文
dcmi資源タイプ
text
DCTERMS.bibliographicCitation
Journal of Cell Biology.131(6) P.1789-P.1800
DC.title
Synapsin I Deficiency Results in the Structural Change in the Presynaptic Terminals in the Murine Nervous System
DC.creator
Takei, Yosuke
Harada, Akihiro
Takeda, Sen
Kobayashi, Katsunori
Terada, Sumio
Noda, Tetsuo
Takahashi, Tomoyuki
Hirokawa, Nobutaka
DC.publisher
The Rockefeller University Press
DC.language" scheme="DCTERMS.RFC1766
英語
DCTERMS.issued" scheme="DCTERMS.W3CDTF
1995-11-15
DC.identifier
info:doi/10.1083/jcb.131.6.1789
DC.identifier" scheme="DCTERMS.URI
http://hdl.handle.net/11094/23087
DCTERMS.abstract
Synapsin I is one of the major synaptic vesicle-associated proteins. Previous experiments implicated its crucial role in synaptogenesis and transmitter release. To better define the role of synapsin I in vivo, we used gene targeting to disrupt the murine synapsin I gene. Mutant mice lacking synapsin I appeared to develop normally and did not have gross anatomical abnormalities. However, when we examined the presynaptic structure of the hippocampal CA3 field in detail, we found that the sizes of mossy fiber giant terminals were significantly smaller, the number of synaptic vesicles became reduced, and the presynaptic structures altered, although the mossy fiber long-term potentiation remained intact. These results suggest significant contribution of synapsin I to the formation and maintenance of the presynaptic structure.
citation_title
Synapsin I Deficiency Results in the Structural Change in the Presynaptic Terminals in the Murine Nervous System
citation_author
Takei, Yosuke
Harada, Akihiro
Takeda, Sen
Kobayashi, Katsunori
Terada, Sumio
Noda, Tetsuo
Takahashi, Tomoyuki
Hirokawa, Nobutaka
citation_publisher
The Rockefeller University Press
citation_language
英語
citation_date
1995-11-15
citation_journal_title
Journal of Cell Biology
citation_volume
131
citation_issue
6
citation_firstpage
1789
citation_lastpage
1800
citation_issn
00219525
citation_doi
info:doi/10.1083/jcb.131.6.1789
citation_public_url
http://hdl.handle.net/11094/23087