Impaired Anaphylactic Responses with Intact Sensitivity to Endotoxin in Mice Lacking a Platelet-activating Factor Receptor

Ishii, Satoshi; Kuwaki, Tomoyuki; Nagase, Takahide; Maki, Kazushige; Tashiro, Fumi; Sunaga, Shinji; Cao, Wei-Hua; Kume, Kazuhiro; Fukuchi, Yoshinosuke; Ikuta, Koichi; Miyazaki, Jun-ichi; Kumada, Mamoru; Shimizu, Takao

doi:https://doi.org/10.1084/jem.187.11.1779

Impaired Anaphylactic Responses with Intact Sensitivity to Endotoxin in Mice Lacking a Platelet-activating Factor Receptor

Ishii, Satoshi; Kuwaki, Tomoyuki; Nagase, Takahide et al.

Journal of Experimental Medicine, 1998, 187(11), 1779-1788

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固定URL: https://hdl.handle.net/11094/23104

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タイトル	Impaired Anaphylactic Responses with Intact Sensitivity to Endotoxin in Mice Lacking a Platelet-activating Factor Receptor
著者	NRID 1000000222935 1000000222935 著者名 Ishii, Satoshi
	NRID 1000080205260 1000080205260 著者名 Kuwaki, Tomoyuki
	NRID 1000040208004 1000040208004 著者名 Nagase, Takahide
	NRID 1000010311424 1000010311424 著者名 Maki, Kazushige
	NRID 1000040136213 1000040136213 researchmap permalink read0184420 read0184420 Scopus Author ID 35397831100 35397831100 著者名 Tashiro, Fumi
	NRID 1000070282621 1000070282621 著者名 Sunaga, Shinji
	著者名 Cao, Wei-Hua
	著者名 Kume, Kazuhiro
	NRID 1000080010156 1000080010156 著者名 Fukuchi, Yoshinosuke
	NRID 1000090193177 1000090193177 著者名 Ikuta, Koichi
	NRID 1000080229830 1000080229830 著者名 Miyazaki, Jun-ichi
	NRID 1000000110487 1000000110487 著者名 Kumada, Mamoru
	NRID 1000040206199 1000040206199 著者名 Shimizu, Takao
キーワード等	platelet-activating factor
	platelet-activating factor receptor
	anaphylaxis
	endotoxic shock
	gene targeting
抄録	Platelet-activating factor (PAF) is a potent phospholipid mediator with diverse biological activities in addition to its well-known ability to stimulate platelet aggregation. Pharmacologic studies had suggested a role for PAF in pregnancy, neuronal cell migration, anaphylaxis, and endotoxic shock. Here we show that disruption of the PAF receptor gene in mice caused a marked reduction in systemic anaphylactic symptoms. Unexpectedly, however, the PAF receptor–deficient mice developed normally, were fertile, and remained sensitive to bacterial endotoxin. These mutant mice clearly show that PAF plays a dominant role in eliciting anaphylaxis, but that it is not essential for reproduction, brain development, or endotoxic shock.
出版者	The Rockefeller University Press
収録物名	Journal of Experimental Medicine
巻(号)	187(11)
ページ	1779-1788
刊行年月	1998-06-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/23104
PISSN	00221007
NCID	AA00697559
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1084/jem.187.11.1779
アクセス権	open access
権利情報	© 1998 Rockefeller University Press
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of Experimental Medicine. 1998, 187(11), p. 1779-1788
DC.title	Impaired Anaphylactic Responses with Intact Sensitivity to Endotoxin in Mice Lacking a Platelet-activating Factor Receptor
DC.creator	Ishii, Satoshi
	Kuwaki, Tomoyuki
	Nagase, Takahide
	Maki, Kazushige
	Tashiro, Fumi
	Sunaga, Shinji
	Cao, Wei-Hua
	Kume, Kazuhiro
	Fukuchi, Yoshinosuke
	Ikuta, Koichi
	Miyazaki, Jun-ichi
	Kumada, Mamoru
	Shimizu, Takao
DC.publisher	The Rockefeller University Press
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	1998-06-01
DC.identifier	https://doi.org/10.1084/jem.187.11.1779
DC.subject	platelet-activating factor
	platelet-activating factor receptor
	anaphylaxis
	endotoxic shock
	gene targeting
DCTERMS.abstract	Platelet-activating factor (PAF) is a potent phospholipid mediator with diverse biological activities in addition to its well-known ability to stimulate platelet aggregation. Pharmacologic studies had suggested a role for PAF in pregnancy, neuronal cell migration, anaphylaxis, and endotoxic shock. Here we show that disruption of the PAF receptor gene in mice caused a marked reduction in systemic anaphylactic symptoms. Unexpectedly, however, the PAF receptor–deficient mice developed normally, were fertile, and remained sensitive to bacterial endotoxin. These mutant mice clearly show that PAF plays a dominant role in eliciting anaphylaxis, but that it is not essential for reproduction, brain development, or endotoxic shock.
DC.rights	© 1998 Rockefeller University Press
DC.format	23104
citation_title	Impaired Anaphylactic Responses with Intact Sensitivity to Endotoxin in Mice Lacking a Platelet-activating Factor Receptor
citation_author	Ishii, Satoshi
	Kuwaki, Tomoyuki
	Nagase, Takahide
	Maki, Kazushige
	Tashiro, Fumi
	Sunaga, Shinji
	Cao, Wei-Hua
	Kume, Kazuhiro
	Fukuchi, Yoshinosuke
	Ikuta, Koichi
	Miyazaki, Jun-ichi
	Kumada, Mamoru
	Shimizu, Takao
citation_publisher	The Rockefeller University Press
citation_language	英語
citation_date	1998-06-01
citation_journal_title	Journal of Experimental Medicine
citation_volume	187
citation_issue	11
citation_firstpage	1779
citation_lastpage	1788
citation_doi	https://doi.org/10.1084/jem.187.11.1779
citation_public_url	https://hdl.handle.net/11094/23104

Impaired Anaphylactic Responses with Intact Sensitivity to Endotoxin in Mice Lacking a Platelet-activating Factor Receptor

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