Impaired Anaphylactic Responses with Intact Sensitivity to Endotoxin in Mice Lacking a Platelet-activating Factor Receptor

Ishii, Satoshi; Kuwaki, Tomoyuki; Nagase, Takahide; Maki, Kazushige; Tashiro, Fumi; Sunaga, Shinji; Cao, Wei-Hua; Kume, Kazuhiro; Fukuchi, Yoshinosuke; Ikuta, Koichi; Miyazaki, Jun-ichi; Kumada, Mamoru; Shimizu, Takao

doi:info:doi/10.1084/jem.187.11.1779

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タイトル	Impaired Anaphylactic Responses with Intact Sensitivity to Endotoxin in Mice Lacking a Platelet-activating Factor Receptor
著者	Ishii, Satoshi Ishii, Satoshi
	Kuwaki, Tomoyuki Kuwaki, Tomoyuki
	Nagase, Takahide Nagase, Takahide
	Maki, Kazushige Maki, Kazushige
	Tashiro, Fumi Tashiro, Fumi
	Sunaga, Shinji Sunaga, Shinji
	Cao, Wei-Hua Cao, Wei-Hua
	Kume, Kazuhiro Kume, Kazuhiro
	Fukuchi, Yoshinosuke Fukuchi, Yoshinosuke
	Ikuta, Koichi Ikuta, Koichi
	Miyazaki, Jun-ichi Miyazaki, Jun-ichi
	Kumada, Mamoru Kumada, Mamoru
	Shimizu, Takao Shimizu, Takao
キーワード等	platelet-activating factor
	platelet-activating factor receptor
	anaphylaxis
	endotoxic shock
	gene targeting
抄録	Platelet-activating factor (PAF) is a potent phospholipid mediator with diverse biological activities in addition to its well-known ability to stimulate platelet aggregation. Pharmacologic studies had suggested a role for PAF in pregnancy, neuronal cell migration, anaphylaxis, and endotoxic shock. Here we show that disruption of the PAF receptor gene in mice caused a marked reduction in systemic anaphylactic symptoms. Unexpectedly, however, the PAF receptor–deficient mice developed normally, were fertile, and remained sensitive to bacterial endotoxin. These mutant mice clearly show that PAF plays a dominant role in eliciting anaphylaxis, but that it is not essential for reproduction, brain development, or endotoxic shock.
公開者	The Rockefeller University Press
掲載誌名	Journal of Experimental Medicine
巻	187
号	11
開始ページ	1779
終了ページ	1788
刊行年月	1998-06-01
ISSN	00221007
NCID	AA00697559
DOI (出版社版)	info:doi/10.1084/jem.187.11.1779
URL	http://hdl.handle.net/11094/23104
権利情報	© 1998 Rockefeller University Press
言語	英語
カテゴリ	学術雑誌論文 Journal Article

著者版フラグ	publisher
NII資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
dcmi資源タイプ	text
DCTERMS.bibliographicCitation	Journal of Experimental Medicine.187(11) P.1779-P.1788
DC.title	Impaired Anaphylactic Responses with Intact Sensitivity to Endotoxin in Mice Lacking a Platelet-activating Factor Receptor
DC.creator	Ishii, Satoshi
	Kuwaki, Tomoyuki
	Nagase, Takahide
	Maki, Kazushige
	Tashiro, Fumi
	Sunaga, Shinji
	Cao, Wei-Hua
	Kume, Kazuhiro
	Fukuchi, Yoshinosuke
	Ikuta, Koichi
	Miyazaki, Jun-ichi
	Kumada, Mamoru
	Shimizu, Takao
DC.publisher	The Rockefeller University Press
DC.language" scheme="DCTERMS.RFC1766	英語
DCTERMS.issued" scheme="DCTERMS.W3CDTF	1998-06-01
DC.identifier	info:doi/10.1084/jem.187.11.1779
DC.identifier" scheme="DCTERMS.URI	http://hdl.handle.net/11094/23104
DC.subject	platelet-activating factor
	platelet-activating factor receptor
	anaphylaxis
	endotoxic shock
	gene targeting
DCTERMS.abstract	Platelet-activating factor (PAF) is a potent phospholipid mediator with diverse biological activities in addition to its well-known ability to stimulate platelet aggregation. Pharmacologic studies had suggested a role for PAF in pregnancy, neuronal cell migration, anaphylaxis, and endotoxic shock. Here we show that disruption of the PAF receptor gene in mice caused a marked reduction in systemic anaphylactic symptoms. Unexpectedly, however, the PAF receptor–deficient mice developed normally, were fertile, and remained sensitive to bacterial endotoxin. These mutant mice clearly show that PAF plays a dominant role in eliciting anaphylaxis, but that it is not essential for reproduction, brain development, or endotoxic shock.
DC.rights	© 1998 Rockefeller University Press
citation_title	Impaired Anaphylactic Responses with Intact Sensitivity to Endotoxin in Mice Lacking a Platelet-activating Factor Receptor
citation_author	Ishii, Satoshi
	Kuwaki, Tomoyuki
	Nagase, Takahide
	Maki, Kazushige
	Tashiro, Fumi
	Sunaga, Shinji
	Cao, Wei-Hua
	Kume, Kazuhiro
	Fukuchi, Yoshinosuke
	Ikuta, Koichi
	Miyazaki, Jun-ichi
	Kumada, Mamoru
	Shimizu, Takao
citation_publisher	The Rockefeller University Press
citation_language	英語
citation_date	1998-06-01
citation_journal_title	Journal of Experimental Medicine
citation_volume	187
citation_issue	11
citation_firstpage	1779
citation_lastpage	1788
citation_issn	00221007
citation_doi	info:doi/10.1084/jem.187.11.1779
citation_public_url	http://hdl.handle.net/11094/23104
citation_keywords	platelet-activating factor
	platelet-activating factor receptor
	anaphylaxis
	endotoxic shock
	gene targeting

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