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論文情報
タイトル
Increased Susceptibility to LPS-induced Endotoxin Shock in Secretory Leukoprotease Inhibitor (SLPI)-deficient Mice
著者
Nakamura, Akira
Nakamura, Akira
Mori, Yuriko
Mori, Yuriko
Hagiwara, koichi
Hagiwara, koichi
Suzuki, Takuji
Suzuki, Takuji
Sakakibara, Tomohiro
Sakakibara, Tomohiro
Kikuchi, Toshiaki
Kikuchi, Toshiaki
Igarashi, Takayuki
Igarashi, Takayuki
Ebina, Masahiro
Ebina, Masahiro
Abe, Tatsuya
Abe, Tatsuya
Miyazaki, Junichi
Miyazaki, Junichi
Takai, Toshiyuki
Takai, Toshiyuki
Nukiwa, Toshihiro
Nukiwa, Toshihiro
キーワード等
endotoxin shock
innate immunity
LPS
NF-κB
SLPI
抄録
Secretory leukoprotease inhibitor (SLPI) protects tissue against the destructive action of neutrophil elastase at the site of inflammation. Recent studies on new functions of SLPI have demonstrated that SLPI may play a larger role in innate immunity than merely as a protease inhibitor. To clarify the functions of SLPI in bacterial infections, we generated SLPI-deficient mice (SLPI−/− mice) and analyzed their response to experimental endotoxin shock induced by lipopolysaccharide (LPS). SLPI−/− mice showed a higher mortality from endotoxin shock than did wild type mice. This may be explained in part by our observation that SLPI−/− macro-phages show higher interleukin 6 and high-mobility group (HMG)-1 production and nuclear factor κB activities after LPS treatment than do SLPI+/+ macrophages. SLPI also affects B cell function. SLPI−/− B cells show more proliferation and IgM production after LPS treatment than SLPI+/+ B cells. Our results suggest that SLPI attenuates excessive inflammatory responses and thus assures balanced functioning of innate immunity.
公開者
The Rockefeller University Press
掲載誌名
Journal of Experimental Medicine
巻
197
号
5
開始ページ
669
終了ページ
674
刊行年月
2003-03-03
ISSN
00221007
NCID
AA00697559
DOI (出版社版)
info:doi/10.1084/jem.20021824
URL
http://hdl.handle.net/11094/23109
権利情報
© 2003 Rockefeller University Press
言語
英語
カテゴリ
学術雑誌論文 Journal Article
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text
DCTERMS.bibliographicCitation
Journal of Experimental Medicine.197(5) P.669-P.674
DC.title
Increased Susceptibility to LPS-induced Endotoxin Shock in Secretory Leukoprotease Inhibitor (SLPI)-deficient Mice
DC.creator
Nakamura, Akira
Mori, Yuriko
Hagiwara, koichi
Suzuki, Takuji
Sakakibara, Tomohiro
Kikuchi, Toshiaki
Igarashi, Takayuki
Ebina, Masahiro
Abe, Tatsuya
Miyazaki, Junichi
Takai, Toshiyuki
Nukiwa, Toshihiro
DC.publisher
The Rockefeller University Press
DC.language" scheme="DCTERMS.RFC1766
英語
DCTERMS.issued" scheme="DCTERMS.W3CDTF
2003-03-03
DC.identifier
info:doi/10.1084/jem.20021824
DC.identifier" scheme="DCTERMS.URI
http://hdl.handle.net/11094/23109
DC.subject
endotoxin shock
innate immunity
LPS
NF-κB
SLPI
DCTERMS.abstract
Secretory leukoprotease inhibitor (SLPI) protects tissue against the destructive action of neutrophil elastase at the site of inflammation. Recent studies on new functions of SLPI have demonstrated that SLPI may play a larger role in innate immunity than merely as a protease inhibitor. To clarify the functions of SLPI in bacterial infections, we generated SLPI-deficient mice (SLPI−/− mice) and analyzed their response to experimental endotoxin shock induced by lipopolysaccharide (LPS). SLPI−/− mice showed a higher mortality from endotoxin shock than did wild type mice. This may be explained in part by our observation that SLPI−/− macro-phages show higher interleukin 6 and high-mobility group (HMG)-1 production and nuclear factor κB activities after LPS treatment than do SLPI+/+ macrophages. SLPI also affects B cell function. SLPI−/− B cells show more proliferation and IgM production after LPS treatment than SLPI+/+ B cells. Our results suggest that SLPI attenuates excessive inflammatory responses and thus assures balanced functioning of innate immunity.
DC.rights
© 2003 Rockefeller University Press
citation_title
Increased Susceptibility to LPS-induced Endotoxin Shock in Secretory Leukoprotease Inhibitor (SLPI)-deficient Mice
citation_author
Nakamura, Akira
Mori, Yuriko
Hagiwara, koichi
Suzuki, Takuji
Sakakibara, Tomohiro
Kikuchi, Toshiaki
Igarashi, Takayuki
Ebina, Masahiro
Abe, Tatsuya
Miyazaki, Junichi
Takai, Toshiyuki
Nukiwa, Toshihiro
citation_publisher
The Rockefeller University Press
citation_language
英語
citation_date
2003-03-03
citation_journal_title
Journal of Experimental Medicine
citation_volume
197
citation_issue
5
citation_firstpage
669
citation_lastpage
674
citation_issn
00221007
citation_doi
info:doi/10.1084/jem.20021824
citation_public_url
http://hdl.handle.net/11094/23109
citation_keywords
endotoxin shock
innate immunity
LPS
NF-κB
SLPI