Reagent-free crosslinking of aqueous gelatin : manufacture and characteristics of gelatin gels irradiated with gamma-ray and electron beam

Furusawa, Kazuya; Mori, Yasutaka; Yoshii, Fumio; Terao, Ken; Nishida, Hirokazu; Nagasawa, Naotsugu; Dobashi, Toshiaki

doi:https://doi.org/10.1163/156856203322553437

アクセス数:252件（2024-04-20 05:55 集計）

固定URL: https://hdl.handle.net/11094/25935

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タイトル	Reagent-free crosslinking of aqueous gelatin : manufacture and characteristics of gelatin gels irradiated with gamma-ray and electron beam
著者	NRID 1000000510017 1000000510017 著者名 Furusawa, Kazuya
	NRID 1000090734294 1000090734294 著者名 Mori, Yasutaka
	著者名 Yoshii, Fumio
	NRID 1000060334132 1000060334132 ORCID 0000-0001-7363-4491 0000-0001-7363-4491 researchmap permalink kenterao kenterao Scopus Author ID 7101653015 7101653015 著者名 Terao, Ken
	著者名 Nishida, Hirokazu
	NRID 1000000370437 1000000370437 著者名 Nagasawa, Naotsugu
	NRID 1000030155626 1000030155626 著者名 Dobashi, Toshiaki
キーワード等	hydrogels
	gelatin
	biodegradability
	radiation
	electron beam
	crosslinking
	proteinase
	reagent-free
内容	This is an Author's Accepted Manuscript of an article published in include the complete citation information for the final version of the artcle as published in the Journal of Biomaterials Science, Polymer Edition, 2003-11, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1163/156856203322553437
抄録	In order to obtain a gelatin hydrogel crosslinked by a reagent-free method, gamma-ray and electron beam radiation was applied to porcine, bovine and fish gelatin gels and the products were characterized by measuring the gel fraction, the swelling ratio and the enzymatic degradability. On increasing the radiation dose, the gel fraction increased and both the swelling ratio and the enzymatic degradability decreased. The transition temperature from gel to sol of the hydrogel containing more than 5% mammal gelatins increased up to more than 90°C when gamma-ray or electron beam were irradiated by more than 10 kGy. The results show that the degree of crosslinking of irradiated gelatin hydrogels increases with increasing irradiation dose and with decreasing concentration. It is suggested that the radiation crosslinking occurs around the physical crosslinking point or multiple helix structure of gelatin gel.
出版者	Taylor and Francis Inc
収録物名	Journal of Biomaterials Science, Polymer Edition
巻(号)	14(11)
ページ	1197-1208
刊行年月	2003-11
言語	英語
ハンドルURL	https://hdl.handle.net/11094/25935
PISSN	09205063
NCID	AA10731799
関連情報 (isVersionOf)	DOI (出版社版) https://doi.org/10.1163/156856203322553437
アクセス権	open access
出版タイプ	Accepted Manuscript
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of Biomaterials Science, Polymer Edition. 2003, 14(11), p. 1197-1208
DC.title	Reagent-free crosslinking of aqueous gelatin : manufacture and characteristics of gelatin gels irradiated with gamma-ray and electron beam
DC.creator	Furusawa, Kazuya
	Mori, Yasutaka
	Yoshii, Fumio
	Terao, Ken
	Nishida, Hirokazu
	Nagasawa, Naotsugu
	Dobashi, Toshiaki
DC.publisher	Taylor and Francis Inc
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2003-11
DC.identifier	https://doi.org/10.1163/156856203322553437
DC.subject	hydrogels
	gelatin
	biodegradability
	radiation
	electron beam
	crosslinking
	proteinase
	reagent-free
DC.description	This is an Author's Accepted Manuscript of an article published in include the complete citation information for the final version of the artcle as published in the Journal of Biomaterials Science, Polymer Edition, 2003-11, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1163/156856203322553437
DCTERMS.abstract	In order to obtain a gelatin hydrogel crosslinked by a reagent-free method, gamma-ray and electron beam radiation was applied to porcine, bovine and fish gelatin gels and the products were characterized by measuring the gel fraction, the swelling ratio and the enzymatic degradability. On increasing the radiation dose, the gel fraction increased and both the swelling ratio and the enzymatic degradability decreased. The transition temperature from gel to sol of the hydrogel containing more than 5% mammal gelatins increased up to more than 90°C when gamma-ray or electron beam were irradiated by more than 10 kGy. The results show that the degree of crosslinking of irradiated gelatin hydrogels increases with increasing irradiation dose and with decreasing concentration. It is suggested that the radiation crosslinking occurs around the physical crosslinking point or multiple helix structure of gelatin gel.
DC.format	application/pdf
citation_title	Reagent-free crosslinking of aqueous gelatin : manufacture and characteristics of gelatin gels irradiated with gamma-ray and electron beam
citation_author	Furusawa, Kazuya
	Mori, Yasutaka
	Yoshii, Fumio
	Terao, Ken
	Nishida, Hirokazu
	Nagasawa, Naotsugu
	Dobashi, Toshiaki
citation_publisher	Taylor and Francis Inc
citation_language	英語
citation_date	2003-11
citation_journal_title	Journal of Biomaterials Science, Polymer Edition
citation_volume	14
citation_issue	11
citation_firstpage	1197
citation_lastpage	1208
citation_doi	https://doi.org/10.1163/156856203322553437
citation_public_url	https://hdl.handle.net/11094/25935

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