Reagent-free crosslinking of aqueous gelatin : manufacture and characteristics of gelatin gels irradiated with gamma-ray and electron beam

Furusawa, Kazuya; Mori, Yasutaka; Yoshii, Fumio; Terao, Ken; Nishida, Hirokazu; Nagasawa, Naotsugu; Dobashi, Toshiaki

doi:info:doi/10.1163/156856203322553437

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タイトル	Reagent-free crosslinking of aqueous gelatin : manufacture and characteristics of gelatin gels irradiated with gamma-ray and electron beam
著者	Furusawa, Kazuya Furusawa, Kazuya
	Mori, Yasutaka Mori, Yasutaka
	Yoshii, Fumio Yoshii, Fumio
	Terao, Ken Terao, Ken
	Nishida, Hirokazu Nishida, Hirokazu
	Nagasawa, Naotsugu Nagasawa, Naotsugu
	Dobashi, Toshiaki Dobashi, Toshiaki
キーワード等	hydrogels
	gelatin
	biodegradability
	radiation
	electron beam
	crosslinking
	proteinase
	reagent-free
内容	This is an Author's Accepted Manuscript of an article published in include the complete citation information for the final version of the artcle as published in the Journal of Biomaterials Science, Polymer Edition, 2003-11, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1163/156856203322553437
抄録	In order to obtain a gelatin hydrogel crosslinked by a reagent-free method, gamma-ray and electron beam radiation was applied to porcine, bovine and fish gelatin gels and the products were characterized by measuring the gel fraction, the swelling ratio and the enzymatic degradability. On increasing the radiation dose, the gel fraction increased and both the swelling ratio and the enzymatic degradability decreased. The transition temperature from gel to sol of the hydrogel containing more than 5% mammal gelatins increased up to more than 90°C when gamma-ray or electron beam were irradiated by more than 10 kGy. The results show that the degree of crosslinking of irradiated gelatin hydrogels increases with increasing irradiation dose and with decreasing concentration. It is suggested that the radiation crosslinking occurs around the physical crosslinking point or multiple helix structure of gelatin gel.
公開者	Taylor and Francis Inc
掲載誌名	Journal of Biomaterials Science, Polymer Edition
巻	14
号	11
開始ページ	1197
終了ページ	1208
刊行年月	2003-11
ISSN	09205063
NCID	AA10731799
DOI (出版社版)	info:doi/10.1163/156856203322553437
URL	http://hdl.handle.net/11094/25935
言語	英語
カテゴリ	学術雑誌論文 Journal Article

著者版フラグ	author
NII資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
dcmi資源タイプ	text
DCTERMS.bibliographicCitation	Journal of Biomaterials Science, Polymer Edition.14(11) P.1197-P.1208
DC.title	Reagent-free crosslinking of aqueous gelatin : manufacture and characteristics of gelatin gels irradiated with gamma-ray and electron beam
DC.creator	Furusawa, Kazuya
	Mori, Yasutaka
	Yoshii, Fumio
	Terao, Ken
	Nishida, Hirokazu
	Nagasawa, Naotsugu
	Dobashi, Toshiaki
DC.publisher	Taylor and Francis Inc
DC.language" scheme="DCTERMS.RFC1766	英語
DCTERMS.issued" scheme="DCTERMS.W3CDTF	2003-11
DC.identifier	info:doi/10.1163/156856203322553437
DC.identifier" scheme="DCTERMS.URI	http://hdl.handle.net/11094/25935
DC.subject	hydrogels
	gelatin
	biodegradability
	radiation
	electron beam
	crosslinking
	proteinase
	reagent-free
DC.description	This is an Author's Accepted Manuscript of an article published in include the complete citation information for the final version of the artcle as published in the Journal of Biomaterials Science, Polymer Edition, 2003-11, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1163/156856203322553437
DCTERMS.abstract	In order to obtain a gelatin hydrogel crosslinked by a reagent-free method, gamma-ray and electron beam radiation was applied to porcine, bovine and fish gelatin gels and the products were characterized by measuring the gel fraction, the swelling ratio and the enzymatic degradability. On increasing the radiation dose, the gel fraction increased and both the swelling ratio and the enzymatic degradability decreased. The transition temperature from gel to sol of the hydrogel containing more than 5% mammal gelatins increased up to more than 90°C when gamma-ray or electron beam were irradiated by more than 10 kGy. The results show that the degree of crosslinking of irradiated gelatin hydrogels increases with increasing irradiation dose and with decreasing concentration. It is suggested that the radiation crosslinking occurs around the physical crosslinking point or multiple helix structure of gelatin gel.
citation_title	Reagent-free crosslinking of aqueous gelatin : manufacture and characteristics of gelatin gels irradiated with gamma-ray and electron beam
citation_author	Furusawa, Kazuya
	Mori, Yasutaka
	Yoshii, Fumio
	Terao, Ken
	Nishida, Hirokazu
	Nagasawa, Naotsugu
	Dobashi, Toshiaki
citation_publisher	Taylor and Francis Inc
citation_language	英語
citation_date	2003-11
citation_journal_title	Journal of Biomaterials Science, Polymer Edition
citation_volume	14
citation_issue	11
citation_firstpage	1197
citation_lastpage	1208
citation_issn	09205063
citation_doi	info:doi/10.1163/156856203322553437
citation_public_url	http://hdl.handle.net/11094/25935
citation_keywords	hydrogels
	gelatin
	biodegradability
	radiation
	electron beam
	crosslinking
	proteinase
	reagent-free

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