Molecular Cloning of a Novel Membrane Glycoprotein, Pal, Specifically Expressed in Photoreceptor Cells of the Retina and Containing Leucine-Rich Repeat

五味, 文; ゴミ, フミ

doi:https://doi.org/10.11501/3184132

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このアイテムへのリンクには次のURLをご利用ください: https://doi.org/10.11501/3184132

このアイテムへのリンクには次のURLをご利用ください: https://hdl.handle.net/11094/3026

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16105_Abstract	pdf	なし	139 KB	83	2014.06.09	要旨/Abstract
16105_Dissertation	pdf	なし	499 KB	110	2012.09.22	論文/Dissertation

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タイトル	Molecular Cloning of a Novel Membrane Glycoprotein, Pal, Specifically Expressed in Photoreceptor Cells of the Retina and Containing Leucine-Rich Repeat
	ロイシンリッチリピートをもつ新規網膜視細胞特異的遺伝子Palのクロー二ング
	ロイシンリッチリピートヲモツシンキモウマクシサイボウトクイテキイデンシ Pal ノクロー二ング
著者	著者名五味, 文 ; ゴミ, フミ
内容	Gomi, Fumi/Imaizumi, Kazunori/Yoneda, Takunari/Taniguchi, Manabu/Mori, Yasutake/Miyoshi, Ko/Hitomi, Junichi/Fujikado, Takashi/Tano, Yasuo/Tohyama, Masaya. Molecular Cloning of a Novel Membrane Glycoprotein, Pal, Specifically Expressed in Photoreceptor Cells of the Retina and Containing Leucine-Rich Repeat. Journal of Neuroscience. 2000. 20(9), p.3206-3213.
抄録	We have isolated a novel retina-specific gene in a screen for genes of which expression is not apparent neonatally in rat retina but is abundant postnatally on day 14 (P14). This gene, named Pal, encodes a putative type I transmembrane protein containing five leucine-rich repeats (LRRs), a single C2-type Ig-like domain, and a single fibronectin type III domain and is considered to be a new member of the LRR and Ig superfamily. No expression of Pal was found in rat retina at P1, but it was detected at P7 and markedly increased with subsequent development. These expression patterns of Pal appeared to be correlated with the development of the photoreceptor outer segments, because in the adult rat retina it was specifically localized in these segments. Ultrastructually, Pal immunoreactivity was distributed diffusely on the disk membrane in the lamellar regions. On the basis of its structural features and localization pattern, Pal may act as a receptor for a certain trophic factor or for an adhesion molecule participating in morphogenesis. The human homolog of Pal was mapped to chromosome 10q23.2-23.3 using fluorescence in situ hybridization.
学位名	博士（医学）
学位授与年月日	2001-03-25
学位授与機関	大阪大学
研究科	医学系
専攻	外科系
学位授与番号	甲第07882号
学位記番号	16105
言語	英語
ハンドルURL	https://hdl.handle.net/11094/3026
DOI	https://doi.org/10.11501/3184132
関連情報 (references)	URI http://www.jneurosci.org/cgi/content/abstract/20/9/3206
アクセス権	open access
権利情報	Copyright: Society for Neuroscience
出版タイプ	Version of Record
カテゴリ	博士論文本文あり / 医学系研究科 / 2000年度
カテゴリ	博士論文 / 医学系研究科 / 2000年度

資源タイプ	博士論文
ローカル資源タイプ	博士論文本文あり
ローカル資源タイプ	博士論文
DCMI資源タイプ	text
DC.title	Molecular Cloning of a Novel Membrane Glycoprotein, Pal, Specifically Expressed in Photoreceptor Cells of the Retina and Containing Leucine-Rich Repeat
	ロイシンリッチリピートをもつ新規網膜視細胞特異的遺伝子Palのクロー二ング
	ロイシンリッチリピートヲモツシンキモウマクシサイボウトクイテキイデンシ Pal ノクロー二ング
DC.creator	五味, 文
DC.creator	ゴミ, フミ
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DC.relation' scheme='DCTERMS.URI	http://www.jneurosci.org/cgi/content/abstract/20/9/3206
DC.description	Gomi, Fumi/Imaizumi, Kazunori/Yoneda, Takunari/Taniguchi, Manabu/Mori, Yasutake/Miyoshi, Ko/Hitomi, Junichi/Fujikado, Takashi/Tano, Yasuo/Tohyama, Masaya. Molecular Cloning of a Novel Membrane Glycoprotein, Pal, Specifically Expressed in Photoreceptor Cells of the Retina and Containing Leucine-Rich Repeat. Journal of Neuroscience. 2000. 20(9), p.3206-3213.
DCTERMS.abstract	We have isolated a novel retina-specific gene in a screen for genes of which expression is not apparent neonatally in rat retina but is abundant postnatally on day 14 (P14). This gene, named Pal, encodes a putative type I transmembrane protein containing five leucine-rich repeats (LRRs), a single C2-type Ig-like domain, and a single fibronectin type III domain and is considered to be a new member of the LRR and Ig superfamily. No expression of Pal was found in rat retina at P1, but it was detected at P7 and markedly increased with subsequent development. These expression patterns of Pal appeared to be correlated with the development of the photoreceptor outer segments, because in the adult rat retina it was specifically localized in these segments. Ultrastructually, Pal immunoreactivity was distributed diffusely on the disk membrane in the lamellar regions. On the basis of its structural features and localization pattern, Pal may act as a receptor for a certain trophic factor or for an adhesion molecule participating in morphogenesis. The human homolog of Pal was mapped to chromosome 10q23.2-23.3 using fluorescence in situ hybridization.
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2001-03-25
DC.rights	Copyright: Society for Neuroscience
DC.identifier	10.11501/3184132
DC.format	application/pdf
DC.format	application/pdf
citation_doi	https://doi.org/10.11501/3184132
citation_title	Molecular Cloning of a Novel Membrane Glycoprotein, Pal, Specifically Expressed in Photoreceptor Cells of the Retina and Containing Leucine-Rich Repeat
	ロイシンリッチリピートをもつ新規網膜視細胞特異的遺伝子Palのクロー二ング
	ロイシンリッチリピートヲモツシンキモウマクシサイボウトクイテキイデンシ Pal ノクロー二ング
citation_author	五味, 文
citation_author	ゴミ, フミ
citation_language	英語
citation_public_url	https://hdl.handle.net/11094/3026
citation_abstract_html_url	http://www.jneurosci.org/cgi/content/abstract/20/9/3206
citation_date	2001-03-25
citation_doi_detail	10.11501/3184132

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