A Novel FERM Domain Including Guanine Nucleotide Exchange Factor Is Involved in Rac Signaling and Regulates Neurite Remodeling

久保, 盾貴

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タイトル	A Novel FERM Domain Including Guanine Nucleotide Exchange Factor Is Involved in Rac Signaling and Regulates Neurite Remodeling
別タイトル	新規のFERM Domain Including Guanine Nucleotide Exchange FactorはRacのシグナルを介し神経軸索の伸展を制御する
タイトル (ヨミ)	シンキ　ノ　FERM Domain Including Guanine Nucleotide Exchange FactorはRac　ノ　シグナル　ヲ　カイシ　シンケイ　ジクサク　ノ　ソシンテン　ヲ　セイギョ　スル
著者	久保, 盾貴久保, 盾貴
著者 (ヨミ)	クボ, タテキ
内容	Kubo, Tateki; Yamashita, Toshihide; Yamaguchi, Atsushi; Sumimoto, Hideki; Hosokawa, Ko; Tohyama, Masaya. A Novel FERM Domain Including Guanine Nucleotide Exchange Factor Is Involved in Rac Signaling and Regulates Neurite Remodeling. Journal of Neuroscience. 2002. 22(19), p.8504-8513.
抄録	The Rho family of small GTPases, key regulators of the actin cytoskeleton in eukaryotic cells from yeast to human, is implicated in the control of neuronal morphology. Guanine nucleotide exchange factors (GEFs) are upstream positive regulators of Rho GTPases and integrate extracellular signaling for appropriate activation of Rho GTPases at specific subcellular regions. Here we describe the identification of a novel Dbl family GEF for Rho GTPases in Homo sapiens and Mus musculus. It contains a tandem Dbl homology-pleckstrin homology domain and FERM domain, characteristic of the plasma membrane proteins linker. This gene, termed FERM domain including RhoGEF (FIR), was abundantly expressed in brain, lung, and testis, as well as embryonic hippocampal and cortical neurons. FIR was found to activate the biochemical pathway specific for Rac1 but not for RhoA or Cdc42. Ectopic expression of FIR in the cortical neurons resulted in significantly shortened neurites and excessive growth cones, presumably mediated by Rac1. These results suggest that FIR may regulate neurite remodeling by mediating the signaling pathways from membrane proteins to Rac.
著者所属研究科	医学系
学位名	博士（医学）
学位授与年月日	2004-06-23
学位授与機関	大阪大学
学位授与番号	14401乙第08910号
学位記番号	18946
URL	http://hdl.handle.net/11094/3294
関連情報 (references)	http://www.jneurosci.org/cgi/content/abstract/22/19/8504
権利情報	Copyright: Society for Neuroscience
言語	英語
カテゴリ	博士論文本文あり / 医学系研究科 / 2004年度
カテゴリ	博士論文 / 医学系研究科 / 2004年度

著者版フラグ	ETD
NII資源タイプ	学位論文
ローカル資源タイプ	博士論文本文あり
ローカル資源タイプ	博士論文
dcmi資源タイプ	text
DC.title	A Novel FERM Domain Including Guanine Nucleotide Exchange Factor Is Involved in Rac Signaling and Regulates Neurite Remodeling
DCTERMS.alternative	新規のFERM Domain Including Guanine Nucleotide Exchange FactorはRacのシグナルを介し神経軸索の伸展を制御する
DC.creator	久保, 盾貴
DC.language" scheme="DCTERMS.RFC1766	英語
DC.identifier" scheme="DCTERMS.URI	http://hdl.handle.net/11094/3294
DC.description	Kubo, Tateki; Yamashita, Toshihide; Yamaguchi, Atsushi; Sumimoto, Hideki; Hosokawa, Ko; Tohyama, Masaya. A Novel FERM Domain Including Guanine Nucleotide Exchange Factor Is Involved in Rac Signaling and Regulates Neurite Remodeling. Journal of Neuroscience. 2002. 22(19), p.8504-8513.
DCTERMS.abstract	The Rho family of small GTPases, key regulators of the actin cytoskeleton in eukaryotic cells from yeast to human, is implicated in the control of neuronal morphology. Guanine nucleotide exchange factors (GEFs) are upstream positive regulators of Rho GTPases and integrate extracellular signaling for appropriate activation of Rho GTPases at specific subcellular regions. Here we describe the identification of a novel Dbl family GEF for Rho GTPases in Homo sapiens and Mus musculus. It contains a tandem Dbl homology-pleckstrin homology domain and FERM domain, characteristic of the plasma membrane proteins linker. This gene, termed FERM domain including RhoGEF (FIR), was abundantly expressed in brain, lung, and testis, as well as embryonic hippocampal and cortical neurons. FIR was found to activate the biochemical pathway specific for Rac1 but not for RhoA or Cdc42. Ectopic expression of FIR in the cortical neurons resulted in significantly shortened neurites and excessive growth cones, presumably mediated by Rac1. These results suggest that FIR may regulate neurite remodeling by mediating the signaling pathways from membrane proteins to Rac.
DCTERMS.issued" scheme="DCTERMS.W3CDTF	2004-06-23
DC.rights	Copyright: Society for Neuroscience
citation_title	A Novel FERM Domain Including Guanine Nucleotide Exchange Factor Is Involved in Rac Signaling and Regulates Neurite Remodeling
citation_author	久保, 盾貴
citation_language	英語
citation_public_url	http://hdl.handle.net/11094/3294
citation_date	2004-06-23

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