A Novel FERM Domain Including Guanine Nucleotide Exchange Factor Is Involved in Rac Signaling and Regulates Neurite Remodeling

久保, 盾貴

アクセス数:759件（2025-07-05 02:06 集計）

固定URL: https://hdl.handle.net/11094/3294

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18946_Dissertation pdf なし 742 KB 163 2012.09.22 論文/Dissertation  

論文情報

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タイトル
A Novel FERM Domain Including Guanine Nucleotide Exchange Factor Is Involved in Rac Signaling and Regulates Neurite Remodeling
新規のFERM Domain Including Guanine Nucleotide Exchange FactorはRacのシグナルを介し神経軸索の伸展を制御する
シンキ　ノ　FERM Domain Including Guanine Nucleotide Exchange FactorはRac　ノ　シグナル　ヲ　カイシ　シンケイ　ジクサク　ノ　ソシンテン　ヲ　セイギョ　スル
著者
NRID
1000000362707 1000000362707
ORCID
0000-0003-1402-5383 0000-0003-1402-5383
researchmap permalink
read0106283 read0106283
Scopus Author ID
55600046500 55600046500
著者名
久保, 盾貴 ; クボ, タテキ
内容
Kubo, Tateki; Yamashita, Toshihide; Yamaguchi, Atsushi; Sumimoto, Hideki; Hosokawa, Ko; Tohyama, Masaya. A Novel FERM Domain Including Guanine Nucleotide Exchange Factor Is Involved in Rac Signaling and Regulates Neurite Remodeling. Journal of Neuroscience. 2002. 22(19), p.8504-8513.
抄録
The Rho family of small GTPases, key regulators of the actin cytoskeleton in eukaryotic cells from yeast to human, is implicated in the control of neuronal morphology. Guanine nucleotide exchange factors (GEFs) are upstream positive regulators of Rho GTPases and integrate extracellular signaling for appropriate activation of Rho GTPases at specific subcellular regions. Here we describe the identification of a novel Dbl family GEF for Rho GTPases in Homo sapiens and Mus musculus. It contains a tandem Dbl homology-pleckstrin homology domain and FERM domain, characteristic of the plasma membrane proteins linker. This gene, termed FERM domain including RhoGEF (FIR), was abundantly expressed in brain, lung, and testis, as well as embryonic hippocampal and cortical neurons. FIR was found to activate the biochemical pathway specific for Rac1 but not for RhoA or Cdc42. Ectopic expression of FIR in the cortical neurons resulted in significantly shortened neurites and excessive growth cones, presumably mediated by Rac1. These results suggest that FIR may regulate neurite remodeling by mediating the signaling pathways from membrane proteins to Rac.
学位名
博士（医学）
学位授与年月日
2004-06-23
学位授与機関
大阪大学
研究科
医学系
学位授与番号
乙第08910号
学位記番号
18946
言語
英語
ハンドルURL
https://hdl.handle.net/11094/3294
関連情報 (references)
URI
http://www.jneurosci.org/cgi/content/abstract/22/19/8504
アクセス権
open access
権利情報
Copyright: Society for Neuroscience
出版タイプ
Version of Record
カテゴリ
博士論文 本文あり / 医学系研究科 / 2004年度
博士論文 / 医学系研究科 / 2004年度