3D-Human Tissue Chips Fabricated by Inkjet Cell Printing

Matsusaki, Michiya; Akashi, Mitsuru

Journal of the Imaging Society of Japan, 2012, 51(5), 524-530

アクセス数:642件（2025-08-30 03:53 集計）

固定URL: https://hdl.handle.net/11094/50628

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タイトル
3D-Human Tissue Chips Fabricated by Inkjet Cell Printing
著者
NRID
1000000419467 1000000419467
researchmap permalink
read0093431 read0093431
Scopus Author ID
6701561701 6701561701
ORCID
0000-0003-4294-9313 0000-0003-4294-9313
著者名
Matsusaki, Michiya
NRID
1000020145460 1000020145460
researchmap permalink
read0094016 read0094016
Scopus Author ID
35463476100 35463476100
著者名
Akashi, Mitsuru
キーワード等
Inkjet printing
Cells
Human tissue chip
Pharmaceutical assay
抄録
We demonstrate a LbL assembly using the inkjet printing of single cells and proteins to enable the fabrication of 3D human micro-tissue arrays, which are integrated structures of micrometer-sized cellular multilayers controlled at the single-cell layer level, for application of pharmaceutical assays. Introduction of automatic inkjet printing of cells and proteins must be necessary for giving an assurance of their reproducibility. The 440 microarrays which were the integration of simplified and multilayered liver structures were successfully developed and comprehensive high-throughput assays of liver functions were performed. We found for the first time that these simplified 3D liver structures, a sandwich of endothelial cells and hepatocytes, revealed the highest functions as compared to other 3D-structures. These 3D-human tissue chips would enable the "total-human tissue models" for tailor-made drug screening.
出版者
日本画像学会
ニホン　ガゾウ　ガッカイ
収録物名
Journal of the Imaging Society of Japan
巻(号)
51(5)
ページ
524-530
刊行年月
2012
言語
英語
ハンドルURL
https://hdl.handle.net/11094/50628
PISSN
13444425
NCID
AA1137305X
アクセス権
open access
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article