Nucleus factory on cavitation bubble for amyloid β fibril

Nakajima, Kichitaro; Ogi, Hirotsugu; Adachi, Kanta; Noi, Kentaro; Hirao, Masahiko; Yagi, Hisashi; Goto, Yuji

doi:info:doi/10.1038/srep22015

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論文情報

タイトル	Nucleus factory on cavitation bubble for amyloid β fibril
著者	Nakajima, Kichitaro Nakajima, Kichitaro
	Ogi, Hirotsugu Ogi, Hirotsugu
	Adachi, Kanta Adachi, Kanta
	Noi, Kentaro Noi, Kentaro
	Hirao, Masahiko Hirao, Masahiko
	Yagi, Hisashi Yagi, Hisashi
	Goto, Yuji Goto, Yuji
内容	Kichitaro Nakajima, Hirotsugu Ogi, Kanta Adachi, Kentaro Noi, Masahiko Hirao, Hisashi Yagi & Yuji Goto "Nucleus factory on cavitation bubble for amyloid β fibril", Scientific Reports, volume 6, Article number: 22015, Springer Nature, 2016
抄録	Structural evolution from monomer to fibril of amyloid β peptide is related to pathogenic mechanism of Alzheimer disease, and its acceleration is a long-running problem in drug development. This study reveals that ultrasonic cavitation bubbles behave as catalysts for nucleation of the peptide: The nucleation reaction is highly dependent on frequency and pressure of acoustic wave, and we discover an optimum acoustical condition, at which the reaction-rate constant for nucleation is increased by three-orders-of magnitudes. A theoretical model is proposed for explaining highly frequency and pressure dependent nucleation reaction, where monomers are captured on the bubble surface during its growth and highly condensed by subsequent bubble collapse, so that they are transiently exposed to high temperatures. Thus, the dual effects of local condensation and local heating contribute to dramatically enhance the nucleation reaction. Our model consistently reproduces the frequency and pressure dependences, supporting its essential applicability.
公開者	Springer Nature
掲載誌名	Scientific Reports
巻	6
開始ページ	22015
刊行年月	2016-02
ISSN	20452322
DOI	info:doi/10.1038/srep22015
URL	http://hdl.handle.net/11094/71267
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
言語	英語
カテゴリ	学術雑誌論文 Journal Article

著者版フラグ	publisher
NII資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
dcmi資源タイプ	text
DCTERMS.bibliographicCitation	Scientific Reports.6 P.22015
DC.title	Nucleus factory on cavitation bubble for amyloid β fibril
DC.creator	Nakajima, Kichitaro
	Ogi, Hirotsugu
	Adachi, Kanta
	Noi, Kentaro
	Hirao, Masahiko
	Yagi, Hisashi
	Goto, Yuji
DC.publisher	Springer Nature
DC.language" scheme="DCTERMS.RFC1766	英語
DCTERMS.issued" scheme="DCTERMS.W3CDTF	2016-02
DC.identifier	info:doi/10.1038/srep22015
DC.identifier" scheme="DCTERMS.URI	http://hdl.handle.net/11094/71267
DC.description	Kichitaro Nakajima, Hirotsugu Ogi, Kanta Adachi, Kentaro Noi, Masahiko Hirao, Hisashi Yagi & Yuji Goto "Nucleus factory on cavitation bubble for amyloid β fibril", Scientific Reports, volume 6, Article number: 22015, Springer Nature, 2016
DCTERMS.abstract	Structural evolution from monomer to fibril of amyloid β peptide is related to pathogenic mechanism of Alzheimer disease, and its acceleration is a long-running problem in drug development. This study reveals that ultrasonic cavitation bubbles behave as catalysts for nucleation of the peptide: The nucleation reaction is highly dependent on frequency and pressure of acoustic wave, and we discover an optimum acoustical condition, at which the reaction-rate constant for nucleation is increased by three-orders-of magnitudes. A theoretical model is proposed for explaining highly frequency and pressure dependent nucleation reaction, where monomers are captured on the bubble surface during its growth and highly condensed by subsequent bubble collapse, so that they are transiently exposed to high temperatures. Thus, the dual effects of local condensation and local heating contribute to dramatically enhance the nucleation reaction. Our model consistently reproduces the frequency and pressure dependences, supporting its essential applicability.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
citation_title	Nucleus factory on cavitation bubble for amyloid β fibril
citation_author	Nakajima, Kichitaro
	Ogi, Hirotsugu
	Adachi, Kanta
	Noi, Kentaro
	Hirao, Masahiko
	Yagi, Hisashi
	Goto, Yuji
citation_publisher	Springer Nature
citation_language	英語
citation_date	2016-02
citation_journal_title	Scientific Reports
citation_volume	6
citation_firstpage	22015
citation_issn	20452322
citation_doi	info:doi/10.1038/srep22015
citation_public_url	http://hdl.handle.net/11094/71267

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