学術雑誌論文

学術雑誌論文

text

Scientific Reports. 2016, 6, p. 22015

Nucleus factory on cavitation bubble for amyloid β fibril

Springer Nature

英語

text

2016-02

https://doi.org/10.1038/srep22015

Kichitaro Nakajima, Hirotsugu Ogi, Kanta Adachi, Kentaro Noi, Masahiko Hirao, Hisashi Yagi & Yuji Goto "Nucleus factory on cavitation bubble for amyloid β fibril", Scientific Reports, volume 6, Article number: 22015, Springer Nature, 2016

Structural evolution from monomer to fibril of amyloid β peptide is related to pathogenic mechanism of Alzheimer disease, and its acceleration is a long-running problem in drug development. This study reveals that ultrasonic cavitation bubbles behave as catalysts for nucleation of the peptide: The nucleation reaction is highly dependent on frequency and pressure of acoustic wave, and we discover an optimum acoustical condition, at which the reaction-rate constant for nucleation is increased by three-orders-of magnitudes. A theoretical model is proposed for explaining highly frequency and pressure dependent nucleation reaction, where monomers are captured on the bubble surface during its growth and highly condensed by subsequent bubble collapse, so that they are transiently exposed to high temperatures. Thus, the dual effects of local condensation and local heating contribute to dramatically enhance the nucleation reaction. Our model consistently reproduces the frequency and pressure dependences, supporting its essential applicability.

© 2016 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License.

71267

Nucleus factory on cavitation bubble for amyloid β fibril

Springer Nature

英語

2016-02

Scientific Reports

6

22015

https://doi.org/10.1038/srep22015

https://hdl.handle.net/11094/71267