Deregulation of alternative splicing of fibronectin pre-mRNA in malignant human liver tumors

Oyama, Fumitaka; Hirohashi, Setsuo; Shimosato, Yukio; Titani, Koiti; Sekiguchi, Kiyotoshi

doi:https://doi.org/10.1016/S0021-9258(18)81621-0

Deregulation of alternative splicing of fibronectin pre-mRNA in malignant human liver tumors

Oyama, Fumitaka; Hirohashi, Setsuo; Shimosato, Yukio et al.

Journal of Biological Chemistry, 1989, 264(18), 10331-10334

アクセス数:482件（2025-08-14 14:25 集計）

固定URL: https://hdl.handle.net/11094/71444

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タイトル	Deregulation of alternative splicing of fibronectin pre-mRNA in malignant human liver tumors
著者	NRID 1000040194641 1000040194641 著者名 Oyama, Fumitaka
	NRID 1000070129625 1000070129625 著者名 Hirohashi, Setsuo
	著者名 Shimosato, Yukio
	NRID 1000060179942 1000060179942 著者名 Titani, Koiti
	NRID 1000050187845 1000050187845 researchmap permalink read0054833 read0054833 Scopus Author ID 7201662709 7201662709 ORCID 0000-0002-6433-1410 0000-0002-6433-1410 著者名 Sekiguchi, Kiyotoshi
内容	This research was originally published in the Journal of Biological Chemistry. F Oyama, S Hirohashi, Y Shimosato, K Titani and K Sekiguchi. Deregulation of alternative splicing of fibronectin pre-mRNA in malignant human liver tumors. J. Biol. Chem. 1989; 264: 10331-10334 © the American Society for Biochemistry and Molecular Biology
抄録	Alternative splicing of fibronectin pre-mRNA at the ED-A region has been shown to be regulated in a tissue- and developmental stage-specific manner. We investigated the splicing pattern at this region in malignant and nonmalignant human liver tissues and found that the relative population of the fibronectin mRNA containing the ED-A sequence is markedly increased in malignant liver tumors. Nontumorous liver tissues including those with chronic hepatitis and cirrhosis did not show any significant change in the alternative splicing at the ED-A region. It was also found that the increased expression of the ED-A-containing fibronectin mRNA closely correlates with the occurrence of portal vein tumor thrombus and intrahepatic metastasis, which are two characteristic features of invasive liver tumors. These results indicate that tissue-specific alternative splicing of fibronectin mRNA is modified in human liver cancer and raise a possibility that the putative molecular machinery governing alternative RNA splicing of not only fibronectin but also other cellular proteins is deregulated in malignant human tumors.
出版者	American Society for Biochemistry and Molecular Biology
収録物名	Journal of Biological Chemistry
巻(号)	264(18)
ページ	10331-10334
刊行年月	1989-06
言語	英語
ハンドルURL	https://hdl.handle.net/11094/71444
eISSN	1083351X
NCID	AA1202441X
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/S0021-9258(18)81621-0
アクセス権	open access
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of Biological Chemistry. 1989, 264(18), p. 10331-10334
DC.title	Deregulation of alternative splicing of fibronectin pre-mRNA in malignant human liver tumors
DC.creator	Oyama, Fumitaka
	Hirohashi, Setsuo
	Shimosato, Yukio
	Titani, Koiti
	Sekiguchi, Kiyotoshi
DC.publisher	American Society for Biochemistry and Molecular Biology
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	1989-06
DC.identifier	https://doi.org/10.1016/S0021-9258(18)81621-0
DC.description	This research was originally published in the Journal of Biological Chemistry. F Oyama, S Hirohashi, Y Shimosato, K Titani and K Sekiguchi. Deregulation of alternative splicing of fibronectin pre-mRNA in malignant human liver tumors. J. Biol. Chem. 1989; 264: 10331-10334 © the American Society for Biochemistry and Molecular Biology
DCTERMS.abstract	Alternative splicing of fibronectin pre-mRNA at the ED-A region has been shown to be regulated in a tissue- and developmental stage-specific manner. We investigated the splicing pattern at this region in malignant and nonmalignant human liver tissues and found that the relative population of the fibronectin mRNA containing the ED-A sequence is markedly increased in malignant liver tumors. Nontumorous liver tissues including those with chronic hepatitis and cirrhosis did not show any significant change in the alternative splicing at the ED-A region. It was also found that the increased expression of the ED-A-containing fibronectin mRNA closely correlates with the occurrence of portal vein tumor thrombus and intrahepatic metastasis, which are two characteristic features of invasive liver tumors. These results indicate that tissue-specific alternative splicing of fibronectin mRNA is modified in human liver cancer and raise a possibility that the putative molecular machinery governing alternative RNA splicing of not only fibronectin but also other cellular proteins is deregulated in malignant human tumors.
DC.format	71444
citation_title	Deregulation of alternative splicing of fibronectin pre-mRNA in malignant human liver tumors
citation_author	Oyama, Fumitaka
	Hirohashi, Setsuo
	Shimosato, Yukio
	Titani, Koiti
	Sekiguchi, Kiyotoshi
citation_publisher	American Society for Biochemistry and Molecular Biology
citation_language	英語
citation_date	1989-06
citation_journal_title	Journal of Biological Chemistry
citation_volume	264
citation_issue	18
citation_firstpage	10331
citation_lastpage	10334
citation_doi	https://doi.org/10.1016/S0021-9258(18)81621-0
citation_public_url	https://hdl.handle.net/11094/71444

Deregulation of alternative splicing of fibronectin pre-mRNA in malignant human liver tumors

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