β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain

Fujioka, Teppei; Kaneko, Naoko; Ajioka, Itsuki; Nakaguchi, Kanako; Omata, Taichi; Ohba, Honoka; Fässler, Reinhard; García-Verdugo, José Manuel; Sekiguchi, Kiyotoshi; Matsukawa, Noriyuki; Sawamoto, Kazunobu

doi:https://doi.org/10.1016/j.ebiom.2017.01.005

アクセス数:225件（2024-04-24 21:53 集計）

固定URL: https://hdl.handle.net/11094/71814

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タイトル	β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain
著者	著者名 Fujioka, Teppei
	NRID 1000020464571 1000020464571 著者名 Kaneko, Naoko
	NRID 1000010348790 1000010348790 著者名 Ajioka, Itsuki
	著者名 Nakaguchi, Kanako
	著者名 Omata, Taichi
	著者名 Ohba, Honoka
	著者名 Fässler, Reinhard
	著者名 García-Verdugo, José Manuel
	NRID 1000050187845 1000050187845 researchmap permalink read0054833 read0054833 Scopus Author ID 7201662709 7201662709 著者名 Sekiguchi, Kiyotoshi
	NRID 1000020305543 1000020305543 著者名 Matsukawa, Noriyuki
	NRID 1000090282350 1000090282350 著者名 Sawamoto, Kazunobu
キーワード等	β1 integrin
	Laminin
	Blood vessel
	Chain migration
	Vasculature-guided migration
	Stroke
内容	Teppei Fujioka, Naoko Kaneko, Itsuki Ajioka, Kanako Nakaguchi, Taichi Omata, Honoka Ohba, Reinhard Fässler, José Manuel García-Verdugo, Kiyotoshi Sekiguchi, Noriyuki Matsukawa, and Kazunobu Sawamoto, "β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain", EBioMedicine, 16, 195-203, Elsevier, 2017
抄録	Cerebral ischemic stroke is a main cause of chronic disability. However, there is currently no effective treatmentto promote recovery from stroke-induced neurological symptoms. Recent studies suggest that after stroke, im-mature neurons, referred to as neuroblasts, generated in a neurogenic niche, the ventricular-subventricularzone, migrate toward the injured area, where they differentiate into mature neurons. Interventions that increasethe number of neuroblasts distributed at and around the lesion facilitate neuronal repair in rodent models for is-chemic stroke, suggesting that promoting neuroblast migration in the post-stroke brain could improve efficientneuronal regeneration. To move toward the lesion, neuroblasts form chain-like aggregates and migrate alongblood vessels, which are thought to increase their migration efficiency. However, the molecular mechanisms reg-ulating thesemigration processesare largely unknown. Here we studied the role ofβ1-class integrins, transmem-brane receptors for extracellular matrix proteins, in these migrating neuroblasts. We found that the neuroblastchain formation and blood vessel-guided migration critically depend onβ1 integrin signaling.β1 integrin facili-tated the adhesion of neuroblasts to laminin and the efficient translocation of their soma during migration. More-over, artificial laminin-containing scaffolds promoted neuroblast chain formation and migration toward theinjured area. These data suggest that laminin signaling viaβ1 integrin supports vasculature-guided neuronal mi-gration to efficiently supply neuroblasts to injured areas. This study also highlights the importance of vascularscaffolds for cell migration in development and regeneration.
出版者	Elsevier
収録物名	EBioMedicine
巻(号)	16
ページ	195-203
刊行年月	2017-02
言語	英語
ハンドルURL	https://hdl.handle.net/11094/71814
eISSN	23523964
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.ebiom.2017.01.005
アクセス権	open access
権利情報	© 2017 The Author(s). Published by Elsevier B.V. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	EBioMedicine. 2017, 16, p. 195-203
DC.title	β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain
DC.creator	Fujioka, Teppei
	Kaneko, Naoko
	Ajioka, Itsuki
	Nakaguchi, Kanako
	Omata, Taichi
	Ohba, Honoka
	Fässler, Reinhard
	García-Verdugo, José Manuel
	Sekiguchi, Kiyotoshi
	Matsukawa, Noriyuki
	Sawamoto, Kazunobu
DC.publisher	Elsevier
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2017-02
DC.identifier	https://doi.org/10.1016/j.ebiom.2017.01.005
DC.subject	β1 integrin
	Laminin
	Blood vessel
	Chain migration
	Vasculature-guided migration
	Stroke
DC.description	Teppei Fujioka, Naoko Kaneko, Itsuki Ajioka, Kanako Nakaguchi, Taichi Omata, Honoka Ohba, Reinhard Fässler, José Manuel García-Verdugo, Kiyotoshi Sekiguchi, Noriyuki Matsukawa, and Kazunobu Sawamoto, "β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain", EBioMedicine, 16, 195-203, Elsevier, 2017
DCTERMS.abstract	Cerebral ischemic stroke is a main cause of chronic disability. However, there is currently no effective treatmentto promote recovery from stroke-induced neurological symptoms. Recent studies suggest that after stroke, im-mature neurons, referred to as neuroblasts, generated in a neurogenic niche, the ventricular-subventricularzone, migrate toward the injured area, where they differentiate into mature neurons. Interventions that increasethe number of neuroblasts distributed at and around the lesion facilitate neuronal repair in rodent models for is-chemic stroke, suggesting that promoting neuroblast migration in the post-stroke brain could improve efficientneuronal regeneration. To move toward the lesion, neuroblasts form chain-like aggregates and migrate alongblood vessels, which are thought to increase their migration efficiency. However, the molecular mechanisms reg-ulating thesemigration processesare largely unknown. Here we studied the role ofβ1-class integrins, transmem-brane receptors for extracellular matrix proteins, in these migrating neuroblasts. We found that the neuroblastchain formation and blood vessel-guided migration critically depend onβ1 integrin signaling.β1 integrin facili-tated the adhesion of neuroblasts to laminin and the efficient translocation of their soma during migration. More-over, artificial laminin-containing scaffolds promoted neuroblast chain formation and migration toward theinjured area. These data suggest that laminin signaling viaβ1 integrin supports vasculature-guided neuronal mi-gration to efficiently supply neuroblasts to injured areas. This study also highlights the importance of vascularscaffolds for cell migration in development and regeneration.
DC.rights	© 2017 The Author(s). Published by Elsevier B.V. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	application/pdf
citation_title	β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain
citation_author	Fujioka, Teppei
	Kaneko, Naoko
	Ajioka, Itsuki
	Nakaguchi, Kanako
	Omata, Taichi
	Ohba, Honoka
	Fässler, Reinhard
	García-Verdugo, José Manuel
	Sekiguchi, Kiyotoshi
	Matsukawa, Noriyuki
	Sawamoto, Kazunobu
citation_publisher	Elsevier
citation_language	英語
citation_date	2017-02
citation_journal_title	EBioMedicine
citation_volume	16
citation_firstpage	195
citation_lastpage	203
citation_doi	https://doi.org/10.1016/j.ebiom.2017.01.005
citation_public_url	https://hdl.handle.net/11094/71814

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