Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis

Gao, Jing; DeRouen, Mindy C.; Chen, Chih-Hsin; Nguyen, Michael; Nguyen, Ngon T.; Ido, Hiroyuki; Harada, Kenji; Sekiguchi, Kiyotoshi; Morgan, Bruce A.; Miner, Jeffery H.; Oro, Anthony E.; Marinkovich, M. Peter

doi:info:doi/10.1101/gad.1689908

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論文情報

タイトル	Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis
著者	Gao, Jing Gao, Jing
	DeRouen, Mindy C. DeRouen, Mindy C.
	Chen, Chih-Hsin Chen, Chih-Hsin
	Nguyen, Michael Nguyen, Michael
	Nguyen, Ngon T. Nguyen, Ngon T.
	Ido, Hiroyuki Ido, Hiroyuki
	Harada, Kenji Harada, Kenji
	Sekiguchi, Kiyotoshi Sekiguchi, Kiyotoshi
	Morgan, Bruce A. Morgan, Bruce A.
	Miner, Jeffery H. Miner, Jeffery H.
	Oro, Anthony E. Oro, Anthony E.
	Marinkovich, M. Peter Marinkovich, M. Peter
キーワード等	Laminin
	primary cilium
	basement membrane
	integrin
	hair
内容	Jing Gao, Mindy C. DeRouen, Chih-Hsin Chen, Michael Nguyen, Ngon T. Nguyen, Hiroyuki Ido, Kenji Harada, Kiyotoshi Sekiguchi, Bruce A. Morgan, Jeffery H. Miner, Anthony E. Oro, and M. Peter Marinkovich, "Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis", Genes & Development, 22(15) 2111-2124, Cold Spring Harbor Laboratory, 2008
抄録	Hair morphogenesis takes place through reciprocal epithelial and mesenchymal signaling; however, the mechanisms controlling signal exchange are poorly understood. Laminins are extracellular proteins that play critical roles in adhesion and signaling. Here we demonstrate the mechanism of how laminin-511 controls hair morphogenesis. Dermal papilla (DP) from laminin-511 mutants showed developmental defects by E16.5, including a failure to maintain expression of the key morphogen noggin. This maintenance was critical as exogenous introduction of noggin or sonic hedgehog (Shh) produced downstream from noggin was sufficient to restore hair follicle development in lama5−/− (laminin-511-null) skin. Hair development required the β1 integrin binding but not the heparin binding domain of laminin-511. Previous studies demonstrated that Shh signaling requires primary cilia, microtubule-based signaling organelles. Laminin-511 mutant DP showed decreased length and structure of primary cilia in vitro and in vivo. Laminin-511, but not laminin-111, restored primary cilia formation in lama5−/− mesenchyme and triggered noggin expression in an Shh- and PDGF-dependent manner. Inhibition of laminin-511 receptor β1 integrin disrupted DP primary cilia formation as well as hair development. These studies show that epithelial-derived laminin-511 is a critical early signal that directs ciliary function and DP maintenance as a requirement for hair follicle downgrowth.
公開者	Cold Spring Harbor Laboratory Press
掲載誌名	Genes & Development
巻	22
号	15
開始ページ	2111
終了ページ	2124
刊行年月	2008-08
ISSN	08909369
ISSN	15495477
NCID	AA10668692
NCID	AA12050792
DOI	info:doi/10.1101/gad.1689908
URL	http://hdl.handle.net/11094/71817
言語	英語
カテゴリ	学術雑誌論文 Journal Article

著者版フラグ	publisher
NII資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
dcmi資源タイプ	text
DCTERMS.bibliographicCitation	Genes & Development.22(15) P.2111-P.2124
DC.title	Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis
DC.creator	Gao, Jing
	DeRouen, Mindy C.
	Chen, Chih-Hsin
	Nguyen, Michael
	Nguyen, Ngon T.
	Ido, Hiroyuki
	Harada, Kenji
	Sekiguchi, Kiyotoshi
	Morgan, Bruce A.
	Miner, Jeffery H.
	Oro, Anthony E.
	Marinkovich, M. Peter
DC.publisher	Cold Spring Harbor Laboratory Press
DC.language" scheme="DCTERMS.RFC1766	英語
DCTERMS.issued" scheme="DCTERMS.W3CDTF	2008-08
DC.identifier	info:doi/10.1101/gad.1689908
DC.identifier" scheme="DCTERMS.URI	http://hdl.handle.net/11094/71817
DC.subject	Laminin
	primary cilium
	basement membrane
	integrin
	hair
DC.description	Jing Gao, Mindy C. DeRouen, Chih-Hsin Chen, Michael Nguyen, Ngon T. Nguyen, Hiroyuki Ido, Kenji Harada, Kiyotoshi Sekiguchi, Bruce A. Morgan, Jeffery H. Miner, Anthony E. Oro, and M. Peter Marinkovich, "Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis", Genes & Development, 22(15) 2111-2124, Cold Spring Harbor Laboratory, 2008
DCTERMS.abstract	Hair morphogenesis takes place through reciprocal epithelial and mesenchymal signaling; however, the mechanisms controlling signal exchange are poorly understood. Laminins are extracellular proteins that play critical roles in adhesion and signaling. Here we demonstrate the mechanism of how laminin-511 controls hair morphogenesis. Dermal papilla (DP) from laminin-511 mutants showed developmental defects by E16.5, including a failure to maintain expression of the key morphogen noggin. This maintenance was critical as exogenous introduction of noggin or sonic hedgehog (Shh) produced downstream from noggin was sufficient to restore hair follicle development in lama5−/− (laminin-511-null) skin. Hair development required the β1 integrin binding but not the heparin binding domain of laminin-511. Previous studies demonstrated that Shh signaling requires primary cilia, microtubule-based signaling organelles. Laminin-511 mutant DP showed decreased length and structure of primary cilia in vitro and in vivo. Laminin-511, but not laminin-111, restored primary cilia formation in lama5−/− mesenchyme and triggered noggin expression in an Shh- and PDGF-dependent manner. Inhibition of laminin-511 receptor β1 integrin disrupted DP primary cilia formation as well as hair development. These studies show that epithelial-derived laminin-511 is a critical early signal that directs ciliary function and DP maintenance as a requirement for hair follicle downgrowth.
citation_title	Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis
citation_author	Gao, Jing
	DeRouen, Mindy C.
	Chen, Chih-Hsin
	Nguyen, Michael
	Nguyen, Ngon T.
	Ido, Hiroyuki
	Harada, Kenji
	Sekiguchi, Kiyotoshi
	Morgan, Bruce A.
	Miner, Jeffery H.
	Oro, Anthony E.
	Marinkovich, M. Peter
citation_publisher	Cold Spring Harbor Laboratory Press
citation_language	英語
citation_date	2008-08
citation_journal_title	Genes & Development
citation_volume	22
citation_issue	15
citation_firstpage	2111
citation_lastpage	2124
citation_issn	08909369
citation_issn	15495477
citation_doi	info:doi/10.1101/gad.1689908
citation_public_url	http://hdl.handle.net/11094/71817
citation_keywords	Laminin
	primary cilium
	basement membrane
	integrin
	hair

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