Study protocol for the PURSUIT-HFpEF study: A Prospective, Multicenter, Observational Study of Patients with Heart Failure with Preserved Ejection Fraction

Suna, Shinichiro; Hikoso, Shungo; Yamada, Takahisa; Uematsu, Masaaki; Yasumura, Yoshio; Nakagawa, Akito; Takeda, Toshihiro; Kojima, Takayuki; Kida, Hirota; Oeun, Bolrathanak; Sunaga, Akihiro; Kitamura, Tetsuhisa; Dohi, Tomoharu; Okada, Katsuki; Mizuno, Hiroya; Nakatani, Daisaku; Iso, Hiroyasu; Matsumura, Yasushi; Sakata, Yasushi

doi:https://doi.org/10.1136/bmjopen-2020-038294

Study protocol for the PURSUIT-HFpEF study: A Prospective, Multicenter, Observational Study of Patients with Heart Failure with Preserved Ejection Fraction

Suna, Shinichiro; Hikoso, Shungo; Yamada, Takahisa et al.

BMJ Open, 2020, 10(10), e038294

アクセス数:2,635件（2025-08-15 07:40 集計）

固定URL: https://hdl.handle.net/11094/78366

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タイトル	Study protocol for the PURSUIT-HFpEF study: A Prospective, Multicenter, Observational Study of Patients with Heart Failure with Preserved Ejection Fraction
著者	NRID 1000040573085 1000040573085 著者名 Suna, Shinichiro
	NRID 1000030423164 1000030423164 researchmap permalink hikoso_osakauniv hikoso_osakauniv Scopus Author ID 6507288830 6507288830 著者名 Hikoso, Shungo
	著者名 Yamada, Takahisa
	NRID 1000000270728 1000000270728 著者名 Uematsu, Masaaki
	著者名 Yasumura, Yoshio
	著者名 Nakagawa, Akito
	NRID 1000070506493 1000070506493 researchmap permalink ttakeda_research ttakeda_research Scopus Author ID 7403572788 7403572788 著者名 Takeda, Toshihiro
	著者名 Kojima, Takayuki
	著者名 Kida, Hirota
	著者名 Oeun, Bolrathanak
	著者名 Sunaga, Akihiro
	NRID 1000030639810 1000030639810 ORCID 0000-0003-0107-0580 0000-0003-0107-0580 researchmap permalink Kitamura_T Kitamura_T Scopus Author ID 22234282700 22234282700 著者名 Kitamura, Tetsuhisa
	NRID 1000090838137 1000090838137 researchmap permalink dohi_1230 dohi_1230 Scopus Author ID 35071263000 35071263000 著者名 Dohi, Tomoharu
	NRID 1000020776489 1000020776489 researchmap permalink katsuki_okada katsuki_okada Scopus Author ID 13613369100 13613369100 著者名 Okada, Katsuki
	NRID 1000060437423 1000060437423 著者名 Mizuno, Hiroya
	NRID 1000060444535 1000060444535 researchmap permalink dsyma dsyma Scopus Author ID 6603545219 6603545219 著者名 Nakatani, Daisaku
	NRID 1000050223053 1000050223053 著者名 Iso, Hiroyasu
	NRID 1000090252642 1000090252642 著者名 Matsumura, Yasushi
	NRID 1000000397671 1000000397671 ORCID 0000-0002-5618-4721 0000-0002-5618-4721 researchmap permalink C4589 C4589 Scopus Author ID 35395964700 35395964700 著者名 Sakata, Yasushi
キーワード等	cardiac epidemiology
	cardiology
	heart failure
内容	Suna S, Hikoso S, Yamada T On behalf of the OCVC-Heart Failure Investigators, et al. Study protocol for the PURSUIT-HFpEF study: a Prospective, Multicenter, Observational Study of Patients with Heart Failure with Preserved Ejection Fraction. BMJ Open 2020;10:e038294. doi: 10.1136/bmjopen-2020-038294
抄録	Introduction Neither the pathophysiology nor an effective treatment for heart failure with preserved ejection fraction (HFpEF) has been elucidated to date. The purpose of this ongoing study is to elucidate the pathophysiology and prognostic factors for patients with HFpEF admitted to participating institutes. We also aim to obtain insights into the development of new diagnostic and treatment methods by analysing patient background factors, clinical data and follow-up information. Methods and analysis This study is a prospective, multicentre, observational study of patients aged ≥20 years admitted due to acute decompensated heart failure with preserved left ventricular ejection fraction (≥50%) and elevated N-terminal-pro brain natriuretic peptide (NT-proBNP) (≥400 pg/mL). The study began in June 2016, with the participation of Osaka University Hospital and 31 affiliated facilities. We will collect data on history in detail, accompanying diseases, quality of life, frailty score, medication history, and laboratory and echocardiographic data. We will follow-up each patient for 5 years, and collect outcome data on mortality, cause of death, and the number and cause of hospitalisation. The target number of registered cases is 1500 cases in 5 years. Ethics and dissemination The protocol was approved by the Institutional Review Board (IRB) of Osaka University Hospital on 24 February 2016 (ID: 15471), and by the IRBs of the all participating facilities. The findings will be disseminated through peer-reviewed publications and conference presentations.
出版者	BMJ Publishing Group
収録物名	BMJ Open
巻(号)	10(10)
ページ	e038294
刊行年月	2020-10-15
言語	英語
ハンドルURL	https://hdl.handle.net/11094/78366
eISSN	20446055
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1136/bmjopen-2020-038294
関連情報 (isIdenticalTo)	PMID 33060085
アクセス権	open access
権利情報	© 2020 Author(s) (or their employer(s)). This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	BMJ Open. 2020, 10(10), p. e038294
DC.title	Study protocol for the PURSUIT-HFpEF study: A Prospective, Multicenter, Observational Study of Patients with Heart Failure with Preserved Ejection Fraction
DC.creator	Suna, Shinichiro
	Hikoso, Shungo
	Yamada, Takahisa
	Uematsu, Masaaki
	Yasumura, Yoshio
	Nakagawa, Akito
	Takeda, Toshihiro
	Kojima, Takayuki
	Kida, Hirota
	Oeun, Bolrathanak
	Sunaga, Akihiro
	Kitamura, Tetsuhisa
	Dohi, Tomoharu
	Okada, Katsuki
	Mizuno, Hiroya
	Nakatani, Daisaku
	Iso, Hiroyasu
	Matsumura, Yasushi
	Sakata, Yasushi
DC.publisher	BMJ Publishing Group
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2020-10-15
DC.identifier	https://doi.org/10.1136/bmjopen-2020-038294
DC.subject	cardiac epidemiology
	cardiology
	heart failure
DC.description	Suna S, Hikoso S, Yamada T On behalf of the OCVC-Heart Failure Investigators, et al. Study protocol for the PURSUIT-HFpEF study: a Prospective, Multicenter, Observational Study of Patients with Heart Failure with Preserved Ejection Fraction. BMJ Open 2020;10:e038294. doi: 10.1136/bmjopen-2020-038294
DCTERMS.abstract	Introduction Neither the pathophysiology nor an effective treatment for heart failure with preserved ejection fraction (HFpEF) has been elucidated to date. The purpose of this ongoing study is to elucidate the pathophysiology and prognostic factors for patients with HFpEF admitted to participating institutes. We also aim to obtain insights into the development of new diagnostic and treatment methods by analysing patient background factors, clinical data and follow-up information. Methods and analysis This study is a prospective, multicentre, observational study of patients aged ≥20 years admitted due to acute decompensated heart failure with preserved left ventricular ejection fraction (≥50%) and elevated N-terminal-pro brain natriuretic peptide (NT-proBNP) (≥400 pg/mL). The study began in June 2016, with the participation of Osaka University Hospital and 31 affiliated facilities. We will collect data on history in detail, accompanying diseases, quality of life, frailty score, medication history, and laboratory and echocardiographic data. We will follow-up each patient for 5 years, and collect outcome data on mortality, cause of death, and the number and cause of hospitalisation. The target number of registered cases is 1500 cases in 5 years. Ethics and dissemination The protocol was approved by the Institutional Review Board (IRB) of Osaka University Hospital on 24 February 2016 (ID: 15471), and by the IRBs of the all participating facilities. The findings will be disseminated through peer-reviewed publications and conference presentations.
DC.rights	© 2020 Author(s) (or their employer(s)). This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
DC.format	78366
citation_title	Study protocol for the PURSUIT-HFpEF study: A Prospective, Multicenter, Observational Study of Patients with Heart Failure with Preserved Ejection Fraction
citation_author	Suna, Shinichiro
	Hikoso, Shungo
	Yamada, Takahisa
	Uematsu, Masaaki
	Yasumura, Yoshio
	Nakagawa, Akito
	Takeda, Toshihiro
	Kojima, Takayuki
	Kida, Hirota
	Oeun, Bolrathanak
	Sunaga, Akihiro
	Kitamura, Tetsuhisa
	Dohi, Tomoharu
	Okada, Katsuki
	Mizuno, Hiroya
	Nakatani, Daisaku
	Iso, Hiroyasu
	Matsumura, Yasushi
	Sakata, Yasushi
citation_publisher	BMJ Publishing Group
citation_language	英語
citation_date	2020-10-15
citation_journal_title	BMJ Open
citation_volume	10
citation_issue	10
citation_firstpage	e038294
citation_doi	https://doi.org/10.1136/bmjopen-2020-038294
citation_pmid	33060085
citation_public_url	https://hdl.handle.net/11094/78366

Study protocol for the PURSUIT-HFpEF study: A Prospective, Multicenter, Observational Study of Patients with Heart Failure with Preserved Ejection Fraction

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