Predictive accuracy of biomarkers for survival among cardiac arrest patients with hypothermia: A prospective observational cohort study in Japan

Okada, Yohei; Kiguchi, Takeyuki; Irisawa, Taro; Yoshiya, Kazuhisa; Yamada, Tomoki; Hayakawa, Koichi; Noguchi, Kazuo; Nishimura, Tetsuro; Ishibe, Takuya; Yagi, Yoshiki; Kishimoto, Masafumi; Shintani, Hiroshi; Hayashi, Yasuyuki; Sogabe, Taku; Morooka, Takaya; Sakamoto, Haruko; Suzuki, Keitaro; Nakamura, Fumiko; Nishioka, Norihiro; Matsuyama, Tasuku; Matsui, Satoshi; Shimazu, Takeshi; Koike, Kaoru; Kawamura, Takashi; Kitamura, Tetsuhisa; Iwami, Taku

doi:https://doi.org/10.1186/s13049-020-00765-2

Predictive accuracy of biomarkers for survival among cardiac arrest patients with hypothermia: A prospective observational cohort study in Japan

Okada, Yohei; Kiguchi, Takeyuki; Irisawa, Taro et al.

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2020, 28, 75

アクセス数:3,210件（2025-10-23 16:05 集計）

固定URL: https://hdl.handle.net/11094/78369

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タイトル	Predictive accuracy of biomarkers for survival among cardiac arrest patients with hypothermia: A prospective observational cohort study in Japan
著者	著者名 Okada, Yohei
	NRID 1000030724380 1000030724380 著者名 Kiguchi, Takeyuki
	NRID 1000050379202 1000050379202 researchmap permalink taroiri taroiri Scopus Author ID 7006596493 7006596493 著者名 Irisawa, Taro
	NRID 1000040379201 1000040379201 著者名 Yoshiya, Kazuhisa
	NRID 1000040623434 1000040623434 著者名 Yamada, Tomoki
	NRID 1000060403086 1000060403086 著者名 Hayakawa, Koichi
	著者名 Noguchi, Kazuo
	著者名 Nishimura, Tetsuro
	著者名 Ishibe, Takuya
	著者名 Yagi, Yoshiki
	著者名 Kishimoto, Masafumi
	著者名 Shintani, Hiroshi
	著者名 Hayashi, Yasuyuki
	著者名 Sogabe, Taku
	著者名 Morooka, Takaya
	著者名 Sakamoto, Haruko
	著者名 Suzuki, Keitaro
	著者名 Nakamura, Fumiko
	著者名 Nishioka, Norihiro
	NRID 1000050829025 1000050829025 著者名 Matsuyama, Tasuku
	著者名 Matsui, Satoshi
	NRID 1000050196474 1000050196474 著者名 Shimazu, Takeshi
	NRID 1000010267164 1000010267164 著者名 Koike, Kaoru
	NRID 1000010252230 1000010252230 著者名 Kawamura, Takashi
	NRID 1000030639810 1000030639810 ORCID 0000-0003-0107-0580 0000-0003-0107-0580 researchmap permalink Kitamura_T Kitamura_T Scopus Author ID 22234282700 22234282700 著者名 Kitamura, Tetsuhisa
	NRID 1000060437291 1000060437291 著者名 Iwami, Taku
キーワード等	Diagnosis
	Hypothermia
	Out-of-hospital cardiac arrest
	Prediction
	Prognosis
内容	Okada, Y., Kiguchi, T., Irisawa, T. et al. Predictive accuracy of biomarkers for survival among cardiac arrest patients with hypothermia: a prospective observational cohort study in Japan. Scand J Trauma Resusc Emerg Med 28, 75 (2020). https://doi.org/10.1186/s13049-020-00765-2
抄録	Background: There is limited information on the predictive accuracy of commonly used predictors, such as lactate, pH or serum potassium for the survival among out-of-hospital cardiac arrest (OHCA) patients with hypothermia. This study aimed to identify the predictive accuracy of these biomarkers for survival among OHCA patients with hypothermia. Methods: In this retrospective analysis, we analyzed the data from a multicenter, prospective nationwide registry among OHCA patients transported to emergency departments in Japan (the JAAM-OHCA Registry). We included all adult (≥18 years) OHCA patients with hypothermia (≤32.0 °C) who were registered from June 2014 to December 2017 and whose blood test results on hospital arrival were recorded. We calculated the predictive accuracy of pH, lactate, and potassium for 1-month survival. Results: Of the 34,754 patients in the JAAM-OHCA database, we included 754 patients from 66 hospitals. The 1-month survival was 5.8% (44/754). The areas under the curve of the predictors and 95% confidence interval were as follows: pH 0.829 [0.767-0.877] and lactate 0.843 [0.793-0.882]. On setting the cutoff points of 6.9 in pH and 120 mg/dL (13.3 mmol/L) in lactate, the predictors had a high sensitivity (lactate: 0.91; pH 0.91) and a low negative likelihood ratio (lactate: 0.14; pH 0.13), which are suitable to exclude survival to 1 month. Furthermore, in additional analysis that included only the patients with potassium values available, a cutoff point of 7.0 (mmol/L) for serum potassium had high sensitivity (0.96) and a low negative likelihood ratio (0.09). Conclusion: This study indicated the predictive accuracy of serum lactate, pH, and potassium for 1-month survival among adult OHCA patients with hypothermia. These biomarkers may help define a more appropriate resuscitation strategy.
出版者	BioMed Central
収録物名	Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
巻(号)	28
ページ	75
刊行年月	2020-08-05
言語	英語
ハンドルURL	https://hdl.handle.net/11094/78369
eISSN	17577241
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1186/s13049-020-00765-2
関連情報 (isIdenticalTo)	PMID 32758271
アクセス権	open access
権利情報	© 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. 2020, 28, p. 75
DC.title	Predictive accuracy of biomarkers for survival among cardiac arrest patients with hypothermia: A prospective observational cohort study in Japan
DC.creator	Okada, Yohei
	Kiguchi, Takeyuki
	Irisawa, Taro
	Yoshiya, Kazuhisa
	Yamada, Tomoki
	Hayakawa, Koichi
	Noguchi, Kazuo
	Nishimura, Tetsuro
	Ishibe, Takuya
	Yagi, Yoshiki
	Kishimoto, Masafumi
	Shintani, Hiroshi
	Hayashi, Yasuyuki
	Sogabe, Taku
	Morooka, Takaya
	Sakamoto, Haruko
	Suzuki, Keitaro
	Nakamura, Fumiko
	Nishioka, Norihiro
	Matsuyama, Tasuku
	Matsui, Satoshi
	Shimazu, Takeshi
	Koike, Kaoru
	Kawamura, Takashi
	Kitamura, Tetsuhisa
	Iwami, Taku
DC.publisher	BioMed Central
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2020-08-05
DC.identifier	https://doi.org/10.1186/s13049-020-00765-2
DC.subject	Diagnosis
	Hypothermia
	Out-of-hospital cardiac arrest
	Prediction
	Prognosis
DC.description	Okada, Y., Kiguchi, T., Irisawa, T. et al. Predictive accuracy of biomarkers for survival among cardiac arrest patients with hypothermia: a prospective observational cohort study in Japan. Scand J Trauma Resusc Emerg Med 28, 75 (2020). https://doi.org/10.1186/s13049-020-00765-2
DCTERMS.abstract	Background: There is limited information on the predictive accuracy of commonly used predictors, such as lactate, pH or serum potassium for the survival among out-of-hospital cardiac arrest (OHCA) patients with hypothermia. This study aimed to identify the predictive accuracy of these biomarkers for survival among OHCA patients with hypothermia. Methods: In this retrospective analysis, we analyzed the data from a multicenter, prospective nationwide registry among OHCA patients transported to emergency departments in Japan (the JAAM-OHCA Registry). We included all adult (≥18 years) OHCA patients with hypothermia (≤32.0 °C) who were registered from June 2014 to December 2017 and whose blood test results on hospital arrival were recorded. We calculated the predictive accuracy of pH, lactate, and potassium for 1-month survival. Results: Of the 34,754 patients in the JAAM-OHCA database, we included 754 patients from 66 hospitals. The 1-month survival was 5.8% (44/754). The areas under the curve of the predictors and 95% confidence interval were as follows: pH 0.829 [0.767-0.877] and lactate 0.843 [0.793-0.882]. On setting the cutoff points of 6.9 in pH and 120 mg/dL (13.3 mmol/L) in lactate, the predictors had a high sensitivity (lactate: 0.91; pH 0.91) and a low negative likelihood ratio (lactate: 0.14; pH 0.13), which are suitable to exclude survival to 1 month. Furthermore, in additional analysis that included only the patients with potassium values available, a cutoff point of 7.0 (mmol/L) for serum potassium had high sensitivity (0.96) and a low negative likelihood ratio (0.09). Conclusion: This study indicated the predictive accuracy of serum lactate, pH, and potassium for 1-month survival among adult OHCA patients with hypothermia. These biomarkers may help define a more appropriate resuscitation strategy.
DC.rights	© 2020 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	78369
citation_title	Predictive accuracy of biomarkers for survival among cardiac arrest patients with hypothermia: A prospective observational cohort study in Japan
citation_author	Okada, Yohei
	Kiguchi, Takeyuki
	Irisawa, Taro
	Yoshiya, Kazuhisa
	Yamada, Tomoki
	Hayakawa, Koichi
	Noguchi, Kazuo
	Nishimura, Tetsuro
	Ishibe, Takuya
	Yagi, Yoshiki
	Kishimoto, Masafumi
	Shintani, Hiroshi
	Hayashi, Yasuyuki
	Sogabe, Taku
	Morooka, Takaya
	Sakamoto, Haruko
	Suzuki, Keitaro
	Nakamura, Fumiko
	Nishioka, Norihiro
	Matsuyama, Tasuku
	Matsui, Satoshi
	Shimazu, Takeshi
	Koike, Kaoru
	Kawamura, Takashi
	Kitamura, Tetsuhisa
	Iwami, Taku
citation_publisher	BioMed Central
citation_language	英語
citation_date	2020-08-05
citation_journal_title	Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
citation_volume	28
citation_firstpage	75
citation_doi	https://doi.org/10.1186/s13049-020-00765-2
citation_pmid	32758271
citation_public_url	https://hdl.handle.net/11094/78369

Predictive accuracy of biomarkers for survival among cardiac arrest patients with hypothermia: A prospective observational cohort study in Japan

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