Dietary acrylamide intake and risk of lung cancer: The Japan public health center based prospective study

Liu, Rong; Zha, Ling; Sobue, Tomotaka; Kitamura, Tetsuhisa; Ishihara, Junko; Kotemori, Ayaka; Ikeda, Sayaka; Sawada, Norie; Iwasaki, Motoki; Tsugane, Shoichiro

doi:https://doi.org/10.3390/nu12082417

Dietary acrylamide intake and risk of lung cancer: The Japan public health center based prospective study

Liu, Rong; Zha, Ling; Sobue, Tomotaka et al.

Nutrients, 2020, 12(8), 2417

アクセス数:1,156件（2025-10-24 06:21 集計）

固定URL: https://hdl.handle.net/11094/78370

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タイトル	Dietary acrylamide intake and risk of lung cancer: The Japan public health center based prospective study
著者	著者名 Liu, Rong
	NRID 1000040895398 1000040895398 researchmap permalink lingzha lingzha Scopus Author ID 57193822882 57193822882 ORCID 0000-0003-4668-4199 0000-0003-4668-4199 著者名 Zha, Ling
	NRID 1000050270674 1000050270674 researchmap permalink read_0159567 read_0159567 Scopus Author ID 7005649935 7005649935 著者名 Sobue, Tomotaka
	NRID 1000030639810 1000030639810 ORCID 0000-0003-0107-0580 0000-0003-0107-0580 researchmap permalink Kitamura_T Kitamura_T Scopus Author ID 22234282700 22234282700 著者名 Kitamura, Tetsuhisa
	NRID 1000030415509 1000030415509 著者名 Ishihara, Junko
	NRID 1000070701233 1000070701233 著者名 Kotemori, Ayaka
	著者名 Ikeda, Sayaka
	NRID 1000000446551 1000000446551 著者名 Sawada, Norie
	NRID 1000060392338 1000060392338 著者名 Iwasaki, Motoki
	NRID 1000040179982 1000040179982 著者名 Tsugane, Shoichiro
キーワード等	Cohort
	Dietary acrylamide
	Japan
	Lung cancer
内容	Liu, R.; Zha, L.; Sobue, T.; Kitamura, T.; Ishihara, J.; Kotemori, A.; Ikeda, S.; Sawada, N.; Iwasaki, M.; Tsugane, S. Dietary Acrylamide Intake and Risk of Lung Cancer: The Japan Public Health Center Based Prospective Study. Nutrients 2020, 12, 2417. https://doi.org/10.3390/nu12082417
抄録	Acrylamide, which forms in heat-treated foods with high carbohydrate content, is a probable human carcinogen. This study aimed to evaluate the association between dietary acrylamide intake and lung cancer using data from the Japan Public Health Center based Prospective Study. Our study included 85,303 participants who completed a food frequency questionnaire. Cox proportional hazards regression models were used to assess hazard ratios and 95% confidence intervals (CIs) after adjusting for confounders. After 14.3 years and 15.4 years of mean follow-up period, 1187 and 485 lung cancer cases were identified in men and women, respectively. The multivariable-adjusted hazard ratios of 10-μg/day increment in acrylamide intake were 1.01 (95% CI, 0.99-1.02) in men and 0.98 (95% CI, 0.95-1.02) in women. Compared with the lowest quartile of acrylamide intake, the hazard ratios for the highest quartile were 1.13 (95% CI, 0.95-1.33; p for trend = 0.12) in men and 1.03 (95% CI, 0.78-1.36; p for trend = 0.86) in women in the multivariable-adjusted model. Moreover, there was also no significant association observed in the stratified analysis for histological subtypes of lung cancer. This study demonstrated that dietary acrylamide intake was not associated with increased lung cancer risk in the Japanese population.
出版者	MDPI
収録物名	Nutrients
巻(号)	12(8)
ページ	2417
刊行年月	2020-08-12
言語	英語
ハンドルURL	https://hdl.handle.net/11094/78370
eISSN	20726643
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.3390/nu12082417
関連情報 (isIdenticalTo)	PMID 32806637
アクセス権	open access
権利情報	© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Nutrients. 2020, 12(8), p. 2417
DC.title	Dietary acrylamide intake and risk of lung cancer: The Japan public health center based prospective study
DC.creator	Liu, Rong
	Zha, Ling
	Sobue, Tomotaka
	Kitamura, Tetsuhisa
	Ishihara, Junko
	Kotemori, Ayaka
	Ikeda, Sayaka
	Sawada, Norie
	Iwasaki, Motoki
	Tsugane, Shoichiro
DC.publisher	MDPI
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2020-08-12
DC.identifier	https://doi.org/10.3390/nu12082417
DC.subject	Cohort
	Dietary acrylamide
	Japan
	Lung cancer
DC.description	Liu, R.; Zha, L.; Sobue, T.; Kitamura, T.; Ishihara, J.; Kotemori, A.; Ikeda, S.; Sawada, N.; Iwasaki, M.; Tsugane, S. Dietary Acrylamide Intake and Risk of Lung Cancer: The Japan Public Health Center Based Prospective Study. Nutrients 2020, 12, 2417. https://doi.org/10.3390/nu12082417
DCTERMS.abstract	Acrylamide, which forms in heat-treated foods with high carbohydrate content, is a probable human carcinogen. This study aimed to evaluate the association between dietary acrylamide intake and lung cancer using data from the Japan Public Health Center based Prospective Study. Our study included 85,303 participants who completed a food frequency questionnaire. Cox proportional hazards regression models were used to assess hazard ratios and 95% confidence intervals (CIs) after adjusting for confounders. After 14.3 years and 15.4 years of mean follow-up period, 1187 and 485 lung cancer cases were identified in men and women, respectively. The multivariable-adjusted hazard ratios of 10-μg/day increment in acrylamide intake were 1.01 (95% CI, 0.99-1.02) in men and 0.98 (95% CI, 0.95-1.02) in women. Compared with the lowest quartile of acrylamide intake, the hazard ratios for the highest quartile were 1.13 (95% CI, 0.95-1.33; p for trend = 0.12) in men and 1.03 (95% CI, 0.78-1.36; p for trend = 0.86) in women in the multivariable-adjusted model. Moreover, there was also no significant association observed in the stratified analysis for histological subtypes of lung cancer. This study demonstrated that dietary acrylamide intake was not associated with increased lung cancer risk in the Japanese population.
DC.rights	© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	78370
citation_title	Dietary acrylamide intake and risk of lung cancer: The Japan public health center based prospective study
citation_author	Liu, Rong
	Zha, Ling
	Sobue, Tomotaka
	Kitamura, Tetsuhisa
	Ishihara, Junko
	Kotemori, Ayaka
	Ikeda, Sayaka
	Sawada, Norie
	Iwasaki, Motoki
	Tsugane, Shoichiro
citation_publisher	MDPI
citation_language	英語
citation_date	2020-08-12
citation_journal_title	Nutrients
citation_volume	12
citation_issue	8
citation_firstpage	2417
citation_doi	https://doi.org/10.3390/nu12082417
citation_pmid	32806637
citation_public_url	https://hdl.handle.net/11094/78370

Dietary acrylamide intake and risk of lung cancer: The Japan public health center based prospective study

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