Physiological function of seminal vesicle secretions on male fecundity

Noda, Taichi; Ikawa, Masahito

Reproductive Medicine and Biology, 2019, 18(3), 241-246

アクセス数:192件（2025-04-18 03:11 集計）

固定URL: https://hdl.handle.net/11094/78557

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タイトル
Physiological function of seminal vesicle secretions on male fecundity
著者
NRID
1000050712551 1000050712551
著者名
Noda, Taichi
NRID
1000020304066 1000020304066
ORCID
0000-0001-9859-6217 0000-0001-9859-6217
researchmap permalink
read0054910 read0054910
Scopus Author ID
16689054500 16689054500
著者名
Ikawa, Masahito
キーワード等
artificial insemination
copulatory plug
male accessory gland
sperm fertilizing ability
uterine environment
内容
Noda, T, Ikawa, M. Physiological function of seminal vesicle secretions on male fecundity. Reprod Med Biol. 2019; 18: 241– 246. https://doi.org/10.1002/rmb2.12282
抄録
Background: A mixture of spermatozoa and accessory gland secretions (from seminal vesicles, prostates, and coagulating glands) is ejaculated into the female reproductive tract at copulation. However, the physiological function of accessory glands on male fecundity remains unclear. Methods: Publications regarding the physiological functions of male accessory glands were summarized. Main findings (Results): The functions of accessory glands have been studied using male rodents surgically removed coagulating glands (CG), prostates (PR), or seminal vesicles (SV). CG-removed males are fertile or subfertile, while the fecundity of PR-removed males is controversial. SV-removed males show copulatory plug defects, leading to fewer sperm in the uterus and severe subfertility. TGM4, SVS2, and PATE4 were identified as essential factors for copulatory plug formation. When the sufficient number of epididymal spermatozoa was artificially injected into a uterus (AI method), they could efficiently fertilize oocytes, implicating that accessory gland secretions are not essential. Seminal vesicle secretions (SVSs) improved fertilization rates only when low numbers of spermatozoa were used for AI. The changes of uterine environment by SVSs could not improve the pregnancy rate. Conclusion: Accessory gland factors are critical for copulatory plug formation and support sperm fertilizing ability.
出版者
John Wiley and Sons Ltd
収録物名
Reproductive Medicine and Biology
巻(号)
18(3)
ページ
241-246
刊行年月
2019-07-08
言語
英語
ハンドルURL
https://hdl.handle.net/11094/78557
PISSN
14455781
eISSN
14470578
NCID
AA11706516
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1002/rmb2.12282
アクセス権
open access
権利情報
© 2019 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine. This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article