Lvrn expression is not critical for mouse placentation

Tobita, Tomohiro; Kiyozumi, Daiji; Muto, Masanaga et al.

Journal of Reproduction and Development, 2019, 65(3), 239-244

アクセス数:181件（2025-04-18 02:10 集計）

固定URL: https://hdl.handle.net/11094/78561

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タイトル
Lvrn expression is not critical for mouse placentation
著者
著者名
Tobita, Tomohiro
NRID
1000070452430 1000070452430
ORCID
0000-0003-3289-227X 0000-0003-3289-227X
researchmap permalink
dkiyozumi dkiyozumi
Scopus Author ID
6506341053 6506341053
著者名
Kiyozumi, Daiji
著者名
Muto, Masanaga
NRID
1000050712551 1000050712551
著者名
Noda, Taichi
NRID
1000020304066 1000020304066
ORCID
0000-0001-9859-6217 0000-0001-9859-6217
researchmap permalink
read0054910 read0054910
Scopus Author ID
16689054500 16689054500
著者名
Ikawa, Masahito
キーワード等
Knockout
Lentivirus
Trophoblast
内容
Tomohiro TOBITA, Daiji KIYOZUMI, Masanaga MUTO, Taichi NODA, Masahito IKAWA, Lvrn expression is not critical for mouse placentation, Journal of Reproduction and Development, 2019, Volume 65, Issue 3, Pages 239-244, Released June 14, 2019, [Advance publication] Released February 10, 2019, Online ISSN 1348-4400, Print ISSN 0916-8818, https://doi.org/10.1262/jrd.2018-157, https://www.jstage.jst.go.jp/article/jrd/65/3/65_2018-157/_article/-char/en
抄録
Preeclampsia is a systemic disease caused by abnormal placentation that affects both mother and fetus. It was reported that Laeverin (LVRN, also known as Aminopeptidase Q) was up-regulated in the placenta of preeclamptic patients. However, physiological and pathological functions of LVRN remained to be unknown. Here we characterized Lvrn function during placentation in mice. RT-PCR showed that Lvrn is expressed in both fetus and placenta during embryogenesis, and several adult tissues. When we overexpressed Lvrn in a placenta-specific manner using lentiviral vectors, we did not see any defects in both placentae and fetuses. The mice carrying Lvrn overexpressing placentas did not show any preeclampsialike symptoms such as maternal high blood pressure and fetal growth restriction. We next ablated Lvrn by CRISPR/Cas9- mediated genome editing to see physiological function. In Lvrn ablated mice, maternal blood pressure during pregnancy was not affected, and both placentas and fetuses grew normally. Collectively, these results suggest that, LVRN is irrelevant to preeclampsia and dispensable for normal placentation and embryonic development in mice.
出版者
The Japanese Society of Animal Reproduction (JSAR)
収録物名
Journal of Reproduction and Development
巻(号)
65(3)
ページ
239-244
刊行年月
2019
言語
英語
ハンドルURL
https://hdl.handle.net/11094/78561
PISSN
09168818
eISSN
13484400
NCID
AA12018734
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1262/jrd.2018-157
PMID
30745494
アクセス権
open access
権利情報
© 2019 the Society for Reproduction and Development. This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article