MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors

Tanaka, Takashi; Shimizu, Shoko; Ueno, Masaki; Fujihara, Yoshitaka; Ikawa, Masahito; Miyata, Shingo

doi:https://doi.org/10.1016/j.ebiom.2018.03.018

MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors

Tanaka, Takashi; Shimizu, Shoko; Ueno, Masaki et al.

EBioMedicine, 2018, 30, 62-73

アクセス数:232件（2025-04-18 02:47 集計）

固定URL: https://hdl.handle.net/11094/78573

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タイトル	MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors
著者	NRID 1000030734694 1000030734694 著者名 Tanaka, Takashi
	NRID 1000050572731 1000050572731 著者名 Shimizu, Shoko
	NRID 1000040435631 1000040435631 著者名 Ueno, Masaki
	NRID 1000070578848 1000070578848 著者名 Fujihara, Yoshitaka
	NRID 1000020304066 1000020304066 ORCID 0000-0001-9859-6217 0000-0001-9859-6217 researchmap permalink read0054910 read0054910 Scopus Author ID 16689054500 16689054500 著者名 Ikawa, Masahito
	NRID 1000070403194 1000070403194 著者名 Miyata, Shingo
キーワード等	Amygdala
	Anxiety-like behaviors
	HPA axis
	MARCKSL1
	Spine formation
内容	Takashi Tanaka, Shoko Shimizu, Masaki Ueno, Yoshitaka Fujihara, Masahito Ikawa, Shingo Miyata, MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors, EBioMedicine, Volume 30, 2018, Pages 62-73, ISSN 2352-3964, https://doi.org/10.1016/j.ebiom.2018.03.018.
抄録	Abnormalities in limbic neural circuits have been implicated in the onset of anxiety disorders. However, the molecular pathogenesis underlying anxiety disorders remains poorly elucidated. Here, we demonstrate that myristoylated alanine-rich C-kinase substrate like 1 (MARCKSL1) regulates amygdala circuitry to control the activity of the hypothalamic-pituitary-adrenal (HPA) axis, as well as induces anxiety-like behaviors in mice. MARCKSL1 expression was predominantly localized in the prefrontal cortex (PFC), hypothalamus, hippocampus, and amygdala of the adult mouse brain. MARCKSL1 transgenic (Tg) mice exhibited anxiety-like behaviors dependent on corticotropin-releasing hormone. MARCKSL1 increased spine formation in the central amygdala, and downregulation of MARCKSL1 in the amygdala normalized both increased HPA axis activity and elevated anxiety-like behaviors in Tg mice. Furthermore, MARCKSL1 expression was increased in the PFC and amygdala in a brain injury model associated with anxiety-like behaviors. Our findings suggest that MARCKSL1 expression in the amygdala plays an important role in anxiety-like behaviors.
出版者	Elsevier B.V.
収録物名	EBioMedicine
巻(号)	30
ページ	62-73
刊行年月	2018-04
言語	英語
ハンドルURL	https://hdl.handle.net/11094/78573
eISSN	23523964
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.ebiom.2018.03.018
関連情報 (isIdenticalTo)	PMID 29580842
アクセス権	open access
権利情報	© 2018 The Authors. Published by Elsevier B.V. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	EBioMedicine. 2018, 30, p. 62-73
DC.title	MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors
DC.creator	Tanaka, Takashi
	Shimizu, Shoko
	Ueno, Masaki
	Fujihara, Yoshitaka
	Ikawa, Masahito
	Miyata, Shingo
DC.publisher	Elsevier B.V.
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2018-04
DC.identifier	https://doi.org/10.1016/j.ebiom.2018.03.018
DC.subject	Amygdala
	Anxiety-like behaviors
	HPA axis
	MARCKSL1
	Spine formation
DC.description	Takashi Tanaka, Shoko Shimizu, Masaki Ueno, Yoshitaka Fujihara, Masahito Ikawa, Shingo Miyata, MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors, EBioMedicine, Volume 30, 2018, Pages 62-73, ISSN 2352-3964, https://doi.org/10.1016/j.ebiom.2018.03.018.
DCTERMS.abstract	Abnormalities in limbic neural circuits have been implicated in the onset of anxiety disorders. However, the molecular pathogenesis underlying anxiety disorders remains poorly elucidated. Here, we demonstrate that myristoylated alanine-rich C-kinase substrate like 1 (MARCKSL1) regulates amygdala circuitry to control the activity of the hypothalamic-pituitary-adrenal (HPA) axis, as well as induces anxiety-like behaviors in mice. MARCKSL1 expression was predominantly localized in the prefrontal cortex (PFC), hypothalamus, hippocampus, and amygdala of the adult mouse brain. MARCKSL1 transgenic (Tg) mice exhibited anxiety-like behaviors dependent on corticotropin-releasing hormone. MARCKSL1 increased spine formation in the central amygdala, and downregulation of MARCKSL1 in the amygdala normalized both increased HPA axis activity and elevated anxiety-like behaviors in Tg mice. Furthermore, MARCKSL1 expression was increased in the PFC and amygdala in a brain injury model associated with anxiety-like behaviors. Our findings suggest that MARCKSL1 expression in the amygdala plays an important role in anxiety-like behaviors.
DC.rights	© 2018 The Authors. Published by Elsevier B.V. This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	78573
citation_title	MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors
citation_author	Tanaka, Takashi
	Shimizu, Shoko
	Ueno, Masaki
	Fujihara, Yoshitaka
	Ikawa, Masahito
	Miyata, Shingo
citation_publisher	Elsevier B.V.
citation_language	英語
citation_date	2018-04
citation_journal_title	EBioMedicine
citation_volume	30
citation_firstpage	62
citation_lastpage	73
citation_doi	https://doi.org/10.1016/j.ebiom.2018.03.018
citation_pmid	29580842
citation_public_url	https://hdl.handle.net/11094/78573

MARCKSL1 Regulates Spine Formation in the Amygdala and Controls the Hypothalamic-Pituitary-Adrenal Axis and Anxiety-Like Behaviors

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