BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection

Kitada, Shoko; Kayama, Hisako; Okuzaki, Daisuke; Koga, Ritsuko; Kobayashi, Masao; Arima, Yasunobu; Kumanogoh, Atsushi; Murakami, Masaaki; Ikawa, Masahito; Takeda, Kiyoshi

doi:https://doi.org/10.1084/jem.20161076

BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection

Kitada, Shoko; Kayama, Hisako; Okuzaki, Daisuke et al.

Journal of Experimental Medicine, 2017, 214(5), 1313-1331

アクセス数:290件（2025-04-06 22:00 集計）

固定URL: https://hdl.handle.net/11094/78580

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タイトル	BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection
著者	著者名 Kitada, Shoko
	NRID 1000040548814 1000040548814 researchmap permalink 0425Kayama_Hisako 0425Kayama_Hisako Scopus Author ID 24390899100 24390899100 著者名 Kayama, Hisako
	NRID 1000000346131 1000000346131 ORCID 0000-0002-4552-783X 0000-0002-4552-783X researchmap permalink read0092307 read0092307 Scopus Author ID 6506703054 6506703054 著者名 Okuzaki, Daisuke
	著者名 Koga, Ritsuko
	著者名 Kobayashi, Masao
	NRID 1000070724748 1000070724748 著者名 Arima, Yasunobu
	NRID 1000010294125 1000010294125 researchmap permalink read0051725 read0051725 Scopus Author ID 6602726311 6602726311 ORCID 0000-0003-4749-7117 0000-0003-4749-7117 著者名 Kumanogoh, Atsushi
	NRID 1000000250514 1000000250514 著者名 Murakami, Masaaki
	NRID 1000020304066 1000020304066 ORCID 0000-0001-9859-6217 0000-0001-9859-6217 researchmap permalink read0054910 read0054910 Scopus Author ID 16689054500 16689054500 著者名 Ikawa, Masahito
	NRID 1000020309446 1000020309446 ORCID 0000-0002-1778-6332 0000-0002-1778-6332 researchmap permalink read0118278 read0118278 Scopus Author ID 7404335442 7404335442 著者名 Takeda, Kiyoshi
内容	Shoko Kitada, Hisako Kayama, Daisuke Okuzaki, Ritsuko Koga, Masao Kobayashi, Yasunobu Arima, Atsushi Kumanogoh, Masaaki Murakami, Masahito Ikawa, Kiyoshi Takeda; BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection. J Exp Med 1 May 2017; 214 (5): 1313–1331. doi: https://doi.org/10.1084/jem.20161076
抄録	Inappropriate IL-17 responses are implicated in chronic tissue inflammation. IL-23 contributes to Trypanosoma cruzi-specific IL-17 production, but the molecular mechanisms underlying regulation of the IL-23-IL-17 axis during T. cruzi infection are poorly understood. Here, we demonstrate a novel function of BATF2 as a negative regulator of Il23a in innate immune cells. IL-17, but not IFN-γ, was more highly produced by CD4+ T cells from spleens and livers of T. cruzi-infected Batf2-/- mice than by those of wild-type mice. In this context, Batf2-/- mice showed severe multiorgan pathology despite reduced parasite burden. T. cruzi-induced IL-23 production was increased in Batf2-/- innate immune cells. The T. cruzi-induced enhanced Th17 response was abrogated in Batf2-/-Il23a-/- mice. The interaction of BATF2 with c-JUN prevented c-JUN-ATF-2 complex formation, inhibiting Il23a expression. These results demonstrate that IFN-γ-inducible BATF2 in innate immune cells controls Th17-mediated immunopathology by suppressing IL-23 production during T. cruzi infection.
出版者	Rockefeller University Press
収録物名	Journal of Experimental Medicine
巻(号)	214(5)
ページ	1313-1331
刊行年月	2017-05-29
言語	英語
ハンドルURL	https://hdl.handle.net/11094/78580
PISSN	00221007
eISSN	15409538
NCID	AA12119243
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1084/jem.20161076
関連情報 (isIdenticalTo)	PMID 28356392
アクセス権	open access
権利情報	© 2017 Kitada et al. This article is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Journal of Experimental Medicine. 2017, 214(5), p. 1313-1331
DC.title	BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection
DC.creator	Kitada, Shoko
	Kayama, Hisako
	Okuzaki, Daisuke
	Koga, Ritsuko
	Kobayashi, Masao
	Arima, Yasunobu
	Kumanogoh, Atsushi
	Murakami, Masaaki
	Ikawa, Masahito
	Takeda, Kiyoshi
DC.publisher	Rockefeller University Press
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2017-05-29
DC.identifier	https://doi.org/10.1084/jem.20161076
DC.description	Shoko Kitada, Hisako Kayama, Daisuke Okuzaki, Ritsuko Koga, Masao Kobayashi, Yasunobu Arima, Atsushi Kumanogoh, Masaaki Murakami, Masahito Ikawa, Kiyoshi Takeda; BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection. J Exp Med 1 May 2017; 214 (5): 1313–1331. doi: https://doi.org/10.1084/jem.20161076
DCTERMS.abstract	Inappropriate IL-17 responses are implicated in chronic tissue inflammation. IL-23 contributes to Trypanosoma cruzi-specific IL-17 production, but the molecular mechanisms underlying regulation of the IL-23-IL-17 axis during T. cruzi infection are poorly understood. Here, we demonstrate a novel function of BATF2 as a negative regulator of Il23a in innate immune cells. IL-17, but not IFN-γ, was more highly produced by CD4+ T cells from spleens and livers of T. cruzi-infected Batf2-/- mice than by those of wild-type mice. In this context, Batf2-/- mice showed severe multiorgan pathology despite reduced parasite burden. T. cruzi-induced IL-23 production was increased in Batf2-/- innate immune cells. The T. cruzi-induced enhanced Th17 response was abrogated in Batf2-/-Il23a-/- mice. The interaction of BATF2 with c-JUN prevented c-JUN-ATF-2 complex formation, inhibiting Il23a expression. These results demonstrate that IFN-γ-inducible BATF2 in innate immune cells controls Th17-mediated immunopathology by suppressing IL-23 production during T. cruzi infection.
DC.rights	© 2017 Kitada et al. This article is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
DC.format	78580
citation_title	BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection
citation_author	Kitada, Shoko
	Kayama, Hisako
	Okuzaki, Daisuke
	Koga, Ritsuko
	Kobayashi, Masao
	Arima, Yasunobu
	Kumanogoh, Atsushi
	Murakami, Masaaki
	Ikawa, Masahito
	Takeda, Kiyoshi
citation_publisher	Rockefeller University Press
citation_language	英語
citation_date	2017-05-29
citation_journal_title	Journal of Experimental Medicine
citation_volume	214
citation_issue	5
citation_firstpage	1313
citation_lastpage	1331
citation_doi	https://doi.org/10.1084/jem.20161076
citation_pmid	28356392
citation_public_url	https://hdl.handle.net/11094/78580

BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection

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