Lentiviral vector-mediated complementation restored fetal viability but not placental hyperplasia in Plac1-deficient mice

Muto, Masanaga; Fujihara, Yoshitaka; Tobita, Tomohiro et al.

Biology of Reproduction, 2016, 94(1), 1-9

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固定URL: https://hdl.handle.net/11094/78591

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タイトル
Lentiviral vector-mediated complementation restored fetal viability but not placental hyperplasia in Plac1-deficient mice
著者
著者名
Muto, Masanaga
NRID
1000070578848 1000070578848
著者名
Fujihara, Yoshitaka
著者名
Tobita, Tomohiro
NRID
1000070452430 1000070452430
ORCID
0000-0003-3289-227X 0000-0003-3289-227X
researchmap permalink
dkiyozumi dkiyozumi
Scopus Author ID
6506341053 6506341053
著者名
Kiyozumi, Daiji
NRID
1000020304066 1000020304066
ORCID
0000-0001-9859-6217 0000-0001-9859-6217
researchmap permalink
read0054910 read0054910
Scopus Author ID
16689054500 16689054500
著者名
Ikawa, Masahito
キーワード等
Imprinting
Intrauterine growth restriction
Knockout
Lentiviral vector
Nuclear transfer
内容
Masanaga Muto, Yoshitaka Fujihara, Tomohiro Tobita, Daiji Kiyozumi, Masahito Ikawa, Lentiviral Vector-Mediated Complementation Restored Fetal Viability but Not Placental Hyperplasia in Plac1-Deficient Mice, Biology of Reproduction, Volume 94, Issue 1, 1 January 2016, 6, 1–9, https://doi.org/10.1095/biolreprod.115.133454
抄録
The X-linked Plac1 gene is maternally expressed in trophoblast cells during placentation, and its disruption causes placental hyperplasia and intrauterine growth restriction. In contrast, Plac1 is also reported to be one of the upregulated genes in the hyperplastic placenta generated by nuclear transfer. However, the effect of overexpressed Plac1 on placental formation and function remained unaddressed. We complemented the Plac1 knockout placental dysfunction by lentiviral vector-mediated, placenta-specific Plac1 transgene expression. Whereas fetal development and the morphology of maternal blood sinuses in the labyrinth zone improved, placental hyperplasia remained, with an expanded the junctional zone that migrated and encroached into the labyrinth zone. Further experiments revealed that wild-type placenta with transgenically expressed Plac1 resulted in placental hyperplasia without the encroaching of the junctional zone. Our findings suggest that Plac1 is involved in trophoblast cell proliferation, differentiation, and migration. Its proper expression is required for normal placentation and fetal development.
出版者
Society for the Study of Reproduction
収録物名
Biology of Reproduction
巻(号)
94(1)
ページ
1-9
刊行年月
2016-01-01
言語
英語
ハンドルURL
https://hdl.handle.net/11094/78591
PISSN
00063363
eISSN
15297268
NCID
AA00565842
関連情報 (isIdenticalTo)
DOI (出版社版)
https://doi.org/10.1095/biolreprod.115.133454
PMID
26586843
アクセス権
open access
権利情報
© 2016 the Society for the Study of Reproduction, Inc. This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
出版タイプ
Version of Record
カテゴリ
学術雑誌論文 Journal Article