SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia

Fujihara, Yoshitaka; Satouh, Yuhkoh; Inoue, Naokazu; Isotani, Ayako; Ikawa, Masahito; Okabe, Masaru

doi:https://doi.org/10.1242/dev.081778

SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia

Fujihara, Yoshitaka; Satouh, Yuhkoh; Inoue, Naokazu et al.

Development, 2012, 139(19), 3583-3589

アクセス数:181件（2025-04-18 02:27 集計）

固定URL: https://hdl.handle.net/11094/78609

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タイトル	SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia
著者	NRID 1000070578848 1000070578848 著者名 Fujihara, Yoshitaka
	NRID 1000040545571 1000040545571 著者名 Satouh, Yuhkoh
	NRID 1000050379096 1000050379096 著者名 Inoue, Naokazu
	NRID 1000020444523 1000020444523 著者名 Isotani, Ayako
	NRID 1000020304066 1000020304066 ORCID 0000-0001-9859-6217 0000-0001-9859-6217 researchmap permalink read0054910 read0054910 Scopus Author ID 16689054500 16689054500 著者名 Ikawa, Masahito
	NRID 1000030089875 1000030089875 著者名 Okabe, Masaru
キーワード等	Acrosome
	Mouse model
	Spermiogenesis
抄録	SPACA1 is a membrane protein that localizes in the equatorial segment of spermatozoa in mammals and is reported to function in sperm-egg fusion. We produced a Spaca1 gene-disrupted mouse line and found that the male mice were infertile. The cause of this sterility was abnormal shaping of the sperm head reminiscent of globozoospermia in humans. Disruption of Spaca1 led to the disappearance of the nuclear plate, a dense lining of the nuclear envelope facing the inner acrosomal membrane. This coincided with the failure of acrosomal expansion during spermiogenesis and resulted in the degeneration and disappearance of the acrosome in mature spermatozoa. Thus, these findings clarify part of the cascade leading to globozoospermia.
出版者	Company of Biologists Ltd
収録物名	Development
巻(号)	139(19)
ページ	3583-3589
刊行年月	2012-10
言語	英語
ハンドルURL	https://hdl.handle.net/11094/78609
PISSN	09501991
eISSN	14779129
NCID	AA10667805
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1242/dev.081778
関連情報 (isIdenticalTo)	PMID 22949614
アクセス権	open access
権利情報	© 2012. Published by The Company of Biologists Ltd.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Development. 2012, 139(19), p. 3583-3589
DC.title	SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia
DC.creator	Fujihara, Yoshitaka
	Satouh, Yuhkoh
	Inoue, Naokazu
	Isotani, Ayako
	Ikawa, Masahito
	Okabe, Masaru
DC.publisher	Company of Biologists Ltd
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2012-10
DC.identifier	https://doi.org/10.1242/dev.081778
DC.subject	Acrosome
	Mouse model
	Spermiogenesis
DCTERMS.abstract	SPACA1 is a membrane protein that localizes in the equatorial segment of spermatozoa in mammals and is reported to function in sperm-egg fusion. We produced a Spaca1 gene-disrupted mouse line and found that the male mice were infertile. The cause of this sterility was abnormal shaping of the sperm head reminiscent of globozoospermia in humans. Disruption of Spaca1 led to the disappearance of the nuclear plate, a dense lining of the nuclear envelope facing the inner acrosomal membrane. This coincided with the failure of acrosomal expansion during spermiogenesis and resulted in the degeneration and disappearance of the acrosome in mature spermatozoa. Thus, these findings clarify part of the cascade leading to globozoospermia.
DC.rights	© 2012. Published by The Company of Biologists Ltd.
DC.format	78609
citation_title	SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia
citation_author	Fujihara, Yoshitaka
	Satouh, Yuhkoh
	Inoue, Naokazu
	Isotani, Ayako
	Ikawa, Masahito
	Okabe, Masaru
citation_publisher	Company of Biologists Ltd
citation_language	英語
citation_date	2012-10
citation_journal_title	Development
citation_volume	139
citation_issue	19
citation_firstpage	3583
citation_lastpage	3589
citation_doi	https://doi.org/10.1242/dev.081778
citation_pmid	22949614
citation_public_url	https://hdl.handle.net/11094/78609

SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia

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