The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion

Inoue, Naokazu; Ikawa, Masahito; Okabe, Masaru

doi:https://doi.org/10.1038/aja.2010.70

The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion

Inoue, Naokazu; Ikawa, Masahito; Okabe, Masaru

Asian Journal of Andrology, 2011, 13(1), 81-87

アクセス数:361件（2025-04-18 02:39 集計）

固定URL: https://hdl.handle.net/11094/78615

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タイトル	The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion
著者	NRID 1000050379096 1000050379096 著者名 Inoue, Naokazu
	NRID 1000020304066 1000020304066 ORCID 0000-0001-9859-6217 0000-0001-9859-6217 researchmap permalink read0054910 read0054910 Scopus Author ID 16689054500 16689054500 著者名 Ikawa, Masahito
	NRID 1000030089875 1000030089875 著者名 Okabe, Masaru
キーワード等	egg
	fusion
	gene-manipulation
	interaction
	IZUMO1
	sperm
	zona pellucida
内容	Inoue, N., Ikawa, M., & Okabe, M. (2011). The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion. Asian Journal of Andrology, 13(1), 81-87. doi:10.1038/aja.2010.70
抄録	An average human ejaculate contains over 100 million sperm, but only a few succeed in accomplishing the journey to an egg by migration through the female reproductive tract. Among these few sperm, only one participates in fertilization. There might be an ingenious molecular mechanism to ensure that the very best sperm fertilize an egg. However, recent gene disruption experiments in mice have revealed that many factors previously described as important for fertilization are largely dispensable. One could argue that the fertilization mechanism is made robust against gene disruptions. However, this is not likely, as there are already six different gene-disrupted mouse lines (Calmegin, Adam1a, Adam2, Adam3, Ace and Pgap1), all of which result in male sterility. The sperm from these animals are known to have defective zona-binding ability and at the same time lose oviduct-migrating ability. Concerning sperm-zona binding, the widely accepted involvement of sugar moiety on zona pellucida 3 (ZP3) is indicated to be dispensable by gene disruption experiments. Thus, the landscape of the mechanism of fertilization is revolving considerably. In the sperm-egg fusion process, CD9 on egg and IZUMO1 on sperm have emerged as essential factors. This review focuses on the mechanism of fertilization elucidated by gene-manipulated animals.
出版者	Asian Society of Andrology
収録物名	Asian Journal of Andrology
巻(号)	13(1)
ページ	81-87
刊行年月	2011-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/78615
PISSN	1008682X
eISSN	17457262
NCID	AA11693946
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1038/aja.2010.70
関連情報 (isIdenticalTo)	PMID 21057513
アクセス権	open access
権利情報	© 2011 AJA, SIMM & SJTU. All rights reserved. Published under the Creative Commons Attribution‐Non Commercial‐Share Alike 3.0 licence
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Asian Journal of Andrology. 2011, 13(1), p. 81-87
DC.title	The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion
DC.creator	Inoue, Naokazu
	Ikawa, Masahito
	Okabe, Masaru
DC.publisher	Asian Society of Andrology
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2011-01
DC.identifier	https://doi.org/10.1038/aja.2010.70
DC.subject	egg
	fusion
	gene-manipulation
	interaction
	IZUMO1
	sperm
	zona pellucida
DC.description	Inoue, N., Ikawa, M., & Okabe, M. (2011). The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion. Asian Journal of Andrology, 13(1), 81-87. doi:10.1038/aja.2010.70
DCTERMS.abstract	An average human ejaculate contains over 100 million sperm, but only a few succeed in accomplishing the journey to an egg by migration through the female reproductive tract. Among these few sperm, only one participates in fertilization. There might be an ingenious molecular mechanism to ensure that the very best sperm fertilize an egg. However, recent gene disruption experiments in mice have revealed that many factors previously described as important for fertilization are largely dispensable. One could argue that the fertilization mechanism is made robust against gene disruptions. However, this is not likely, as there are already six different gene-disrupted mouse lines (Calmegin, Adam1a, Adam2, Adam3, Ace and Pgap1), all of which result in male sterility. The sperm from these animals are known to have defective zona-binding ability and at the same time lose oviduct-migrating ability. Concerning sperm-zona binding, the widely accepted involvement of sugar moiety on zona pellucida 3 (ZP3) is indicated to be dispensable by gene disruption experiments. Thus, the landscape of the mechanism of fertilization is revolving considerably. In the sperm-egg fusion process, CD9 on egg and IZUMO1 on sperm have emerged as essential factors. This review focuses on the mechanism of fertilization elucidated by gene-manipulated animals.
DC.rights	© 2011 AJA, SIMM & SJTU. All rights reserved. Published under the Creative Commons Attribution‐Non Commercial‐Share Alike 3.0 licence
DC.format	78615
citation_title	The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion
citation_author	Inoue, Naokazu
	Ikawa, Masahito
	Okabe, Masaru
citation_publisher	Asian Society of Andrology
citation_language	英語
citation_date	2011-01
citation_journal_title	Asian Journal of Andrology
citation_volume	13
citation_issue	1
citation_firstpage	81
citation_lastpage	87
citation_doi	https://doi.org/10.1038/aja.2010.70
citation_pmid	21057513
citation_public_url	https://hdl.handle.net/11094/78615

The mechanism of sperm-egg interaction and the involvement of IZUMO1 in fusion

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