Renin-angiotensin-aldosterone system polymorphisms and 5-year mortality in survivors of acute myocardial infarction a report from the osaka acute coronary insuffi ciency study

Hara, Masahiko; Sakata, Yasuhiko; Nakatani, Daisaku; Suna, Shinichiro; Usami, Masaya; Matsumoto, Sen; Sugitani, Toshifumi; Ozaki, Kouichi; Nishino, Masami; Sato, Hiroshi; Kitamura, Tetsuhisa; Nanto, Shinsuke; Hamasaki, Toshimitsu; Tanaka, Toshihiro; Hori, Masatsugu; Komuro, Issei

doi:https://doi.org/10.1536/ihj.13-288

Renin-angiotensin-aldosterone system polymorphisms and 5-year mortality in survivors of acute myocardial infarction a report from the osaka acute coronary insuffi ciency study

Hara, Masahiko; Sakata, Yasuhiko; Nakatani, Daisaku et al.

International Heart Journal, 2014, 55(3), 190-196

アクセス数:320件（2025-05-09 11:50 集計）

固定URL: https://hdl.handle.net/11094/78723

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タイトル	Renin-angiotensin-aldosterone system polymorphisms and 5-year mortality in survivors of acute myocardial infarction a report from the osaka acute coronary insuffi ciency study
著者	著者名 Hara, Masahiko
	NRID 1000090379206 1000090379206 著者名 Sakata, Yasuhiko
	NRID 1000060444535 1000060444535 researchmap permalink dsyma dsyma Scopus Author ID 6603545219 6603545219 著者名 Nakatani, Daisaku
	NRID 1000040573085 1000040573085 著者名 Suna, Shinichiro
	著者名 Usami, Masaya
	著者名 Matsumoto, Sen
	NRID 1000070626879 1000070626879 著者名 Sugitani, Toshifumi
	著者名 Ozaki, Kouichi
	著者名 Nishino, Masami
	NRID 1000010294092 1000010294092 著者名 Sato, Hiroshi
	NRID 1000030639810 1000030639810 ORCID 0000-0003-0107-0580 0000-0003-0107-0580 researchmap permalink Kitamura_T Kitamura_T Scopus Author ID 22234282700 22234282700 著者名 Kitamura, Tetsuhisa
	著者名 Nanto, Shinsuke
	NRID 1000040379243 1000040379243 著者名 Hamasaki, Toshimitsu
	NRID 1000050292850 1000050292850 著者名 Tanaka, Toshihiro
	著者名 Hori, Masatsugu
	NRID 1000030260483 1000030260483 著者名 Komuro, Issei
キーワード等	Genetics
キーワード等	Secondary prevention
抄録	This study sought to evaluate whether genetic variants in the renin-angiotensin-aldosterone system (RAAS) have an impact on long-term mortality after acute myocardial infarction (AMI) in the percutaneous coronary intervention (PCI) era. We investigated the impacts of individual and combinations of 4 major RAAS genetic variants, angiotensinogen (AGT) T1311C, angiotensin-converting enzyme (ACE) insertion/deletion (I/D), angiotensin 2 type 1 receptor A1166C, and aldosterone synthase T4660C on 5-year mortality in 3149 post-AMI patients using multivariate Cox regression analysis. The predictive accuracy of all possible RAAS genetic combinations was evaluated using Cox regression analysis, and the best combination that affected prognosis was determined based on the minimal Akaike Information Criterion. There were 220 deaths during a median follow-up of 4.9 years. Independent analyses of any single RAAS variant did not show signifi cant impacts on 5-year mortality. However, analyses in combination revealed that absence of both AGT CC genotype and ACE D allele was associated with lower 5-year mortality (log-rank P = 0.005). Patients with at least either of the AGT CC or ACE D allele had increased mortality with adjusted hazard ratios of 2.07 (95% confi dence interval 1.18-3.65, P = 0.012), compared with those with neither the AGT CC nor ACE D allele. Among the 4 RAAS genetic variants examined, a combination of AGT and ACE polymorphisms was associated with 5-year mortality after AMI.
出版者	International Heart Journal Association
収録物名	International Heart Journal
巻(号)	55(3)
ページ	190-196
刊行年月	2014-05-26
言語	英語
ハンドルURL	https://hdl.handle.net/11094/78723
PISSN	13492365
eISSN	13493299
NCID	AA12013242
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1536/ihj.13-288
関連情報 (isIdenticalTo)	PMID 24806378
アクセス権	open access
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	International Heart Journal. 2014, 55(3), p. 190-196
DC.title	Renin-angiotensin-aldosterone system polymorphisms and 5-year mortality in survivors of acute myocardial infarction a report from the osaka acute coronary insuffi ciency study
DC.creator	Hara, Masahiko
	Sakata, Yasuhiko
	Nakatani, Daisaku
	Suna, Shinichiro
	Usami, Masaya
	Matsumoto, Sen
	Sugitani, Toshifumi
	Ozaki, Kouichi
	Nishino, Masami
	Sato, Hiroshi
	Kitamura, Tetsuhisa
	Nanto, Shinsuke
	Hamasaki, Toshimitsu
	Tanaka, Toshihiro
	Hori, Masatsugu
	Komuro, Issei
DC.publisher	International Heart Journal Association
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2014-05-26
DC.identifier	https://doi.org/10.1536/ihj.13-288
DC.subject	Genetics
DC.subject	Secondary prevention
DCTERMS.abstract	This study sought to evaluate whether genetic variants in the renin-angiotensin-aldosterone system (RAAS) have an impact on long-term mortality after acute myocardial infarction (AMI) in the percutaneous coronary intervention (PCI) era. We investigated the impacts of individual and combinations of 4 major RAAS genetic variants, angiotensinogen (AGT) T1311C, angiotensin-converting enzyme (ACE) insertion/deletion (I/D), angiotensin 2 type 1 receptor A1166C, and aldosterone synthase T4660C on 5-year mortality in 3149 post-AMI patients using multivariate Cox regression analysis. The predictive accuracy of all possible RAAS genetic combinations was evaluated using Cox regression analysis, and the best combination that affected prognosis was determined based on the minimal Akaike Information Criterion. There were 220 deaths during a median follow-up of 4.9 years. Independent analyses of any single RAAS variant did not show signifi cant impacts on 5-year mortality. However, analyses in combination revealed that absence of both AGT CC genotype and ACE D allele was associated with lower 5-year mortality (log-rank P = 0.005). Patients with at least either of the AGT CC or ACE D allele had increased mortality with adjusted hazard ratios of 2.07 (95% confi dence interval 1.18-3.65, P = 0.012), compared with those with neither the AGT CC nor ACE D allele. Among the 4 RAAS genetic variants examined, a combination of AGT and ACE polymorphisms was associated with 5-year mortality after AMI.
DC.format	78723
citation_title	Renin-angiotensin-aldosterone system polymorphisms and 5-year mortality in survivors of acute myocardial infarction a report from the osaka acute coronary insuffi ciency study
citation_author	Hara, Masahiko
	Sakata, Yasuhiko
	Nakatani, Daisaku
	Suna, Shinichiro
	Usami, Masaya
	Matsumoto, Sen
	Sugitani, Toshifumi
	Ozaki, Kouichi
	Nishino, Masami
	Sato, Hiroshi
	Kitamura, Tetsuhisa
	Nanto, Shinsuke
	Hamasaki, Toshimitsu
	Tanaka, Toshihiro
	Hori, Masatsugu
	Komuro, Issei
citation_publisher	International Heart Journal Association
citation_language	英語
citation_date	2014-05-26
citation_journal_title	International Heart Journal
citation_volume	55
citation_issue	3
citation_firstpage	190
citation_lastpage	196
citation_doi	https://doi.org/10.1536/ihj.13-288
citation_pmid	24806378
citation_public_url	https://hdl.handle.net/11094/78723

Renin-angiotensin-aldosterone system polymorphisms and 5-year mortality in survivors of acute myocardial infarction a report from the osaka acute coronary insuffi ciency study

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