Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction

Hara, Masahiko; Sakata, Yasuhiko; Nakatani, Daisaku; Suna, Shinichiro; Usami, Masaya; Matsumoto, Sen; Hamasaki, Toshimitsu; Doi, Yasuji; Nishino, Masami; Sato, Hiroshi; Kitamura, Tetsuhisa; Nanto, Shinsuke; Hori, Masatsugu; Komuro, Issei

doi:https://doi.org/10.1253/circj.CJ-12-0875

Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction

Hara, Masahiko; Sakata, Yasuhiko; Nakatani, Daisaku et al.

Circulation Journal, 2012, 77(1), 153-162

アクセス数:1,170件（2025-08-15 07:42 集計）

固定URL: https://hdl.handle.net/11094/78934

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タイトル	Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction
著者	著者名 Hara, Masahiko
	NRID 1000090379206 1000090379206 著者名 Sakata, Yasuhiko
	NRID 1000060444535 1000060444535 researchmap permalink dsyma dsyma Scopus Author ID 6603545219 6603545219 著者名 Nakatani, Daisaku
	NRID 1000040573085 1000040573085 著者名 Suna, Shinichiro
	著者名 Usami, Masaya
	著者名 Matsumoto, Sen
	NRID 1000040379243 1000040379243 著者名 Hamasaki, Toshimitsu
	著者名 Doi, Yasuji
	著者名 Nishino, Masami
	NRID 1000010294092 1000010294092 著者名 Sato, Hiroshi
	NRID 1000030639810 1000030639810 ORCID 0000-0003-0107-0580 0000-0003-0107-0580 researchmap permalink Kitamura_T Kitamura_T Scopus Author ID 22234282700 22234282700 著者名 Kitamura, Tetsuhisa
	著者名 Nanto, Shinsuke
	著者名 Hori, Masatsugu
	NRID 1000030260483 1000030260483 著者名 Komuro, Issei
キーワード等	Acute myocardial infarction
	Docosahexaenoic acid
	Eicosapentaenoic acid
	Heart failure
	N-3 polyunsaturated fatty acids
内容	Masahiko Hara, Yasuhiko Sakata, Daisaku Nakatani, Shinichiro Suna, Masaya Usami, Sen Matsumoto, Toshimitsu Hamasaki, Yasuji Doi, Masami Nishino, Hiroshi Sato, Tetsuhisa Kitamura, Shinsuke Nanto, Masatsugu Hori, Issei Komuro, for the Osaka Acute Coronary Insufficiency Study (OACIS) Investigators, Low Levels of Serum n-3 Polyunsaturated Fatty Acids Are Associated With Worse Heart Failure-Free Survival in Patients After Acute Myocardial Infarction, Circulation Journal, 2013, Volume 77, Issue 1, Pages 153-162, Released December 25, 2012, [Advance publication] Released October 06, 2012, Online ISSN 1347-4820, Print ISSN 1346-9843, https://doi.org/10.1253/circj.CJ-12-0875, https://www.jstage.jst.go.jp/article/circj/77/1/77_CJ-12-0875/_article/-char/en
抄録	Background: Intake of long-chain n-3 polyunsaturated fatty acids (n-3 PUFA), including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), is associated with a lower risk of atherosclerotic cardiovascular events, particularly acute myocardial infarction (AMI). However, limited data are available regarding the association between serum n-3 PUFA levels and heart failure (HF) events in survivors of AMI. Methods and Results: We evaluated whether serum DHA and EPA levels were associated with HF-free survival and HF hospitalization rates after AMI. A total of 712 patients were divided into 3 groups according to their tertile serum levels of DHA and EPA (Low, Middle, and High). Propensity-score-stratified Cox regression analysis revealed that DHA- and EPA-Low groups presented statistically significant worse HF-free survival (hazard ratio (HR) 1.68, 95% confidence interval (CI) 1.03-2.72, P=0.0358, and HR 1.69, 95% CI 1.05-2.72, P=0.0280, respectively), with the EPALow group having a higher risk of HF hospitalization (HR 2.40, 95% CI 1.21-4.75, P=0.0097) than the DHA-Low group (HR 1.72, 95% CI 0.86-3.45, P=0.1224). The relationship between a low DHA or EPA level and decreased HF-free survival was almost common to all subgroups; however, the effect of low serum EPA on HF hospitalization was prominent in male patients, and those with low levels of high-density lipoprotein cholesterol or without statin therapy. Conclusions: Low levels of circulating n-3 PUFA are associated with decreased HF-free survival in post-AMI patients.
出版者	Japanese Circulation Society
収録物名	Circulation Journal
巻(号)	77(1)
ページ	153-162
刊行年月	2012-12-25
言語	英語
ハンドルURL	https://hdl.handle.net/11094/78934
PISSN	13469843
eISSN	13474820
NCID	AA11591968
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1253/circj.CJ-12-0875
関連情報 (isIdenticalTo)	PMID 23047296
アクセス権	open access
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCTERMS.bibliographicCitation	Circulation Journal. 2012, 77(1), p. 153-162
DC.title	Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction
DC.creator	Hara, Masahiko
	Sakata, Yasuhiko
	Nakatani, Daisaku
	Suna, Shinichiro
	Usami, Masaya
	Matsumoto, Sen
	Hamasaki, Toshimitsu
	Doi, Yasuji
	Nishino, Masami
	Sato, Hiroshi
	Kitamura, Tetsuhisa
	Nanto, Shinsuke
	Hori, Masatsugu
	Komuro, Issei
DC.publisher	Japanese Circulation Society
DC.language' scheme='DCTERMS.RFC1766	英語
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2012-12-25
DC.identifier	https://doi.org/10.1253/circj.CJ-12-0875
DC.subject	Acute myocardial infarction
	Docosahexaenoic acid
	Eicosapentaenoic acid
	Heart failure
	N-3 polyunsaturated fatty acids
DC.description	Masahiko Hara, Yasuhiko Sakata, Daisaku Nakatani, Shinichiro Suna, Masaya Usami, Sen Matsumoto, Toshimitsu Hamasaki, Yasuji Doi, Masami Nishino, Hiroshi Sato, Tetsuhisa Kitamura, Shinsuke Nanto, Masatsugu Hori, Issei Komuro, for the Osaka Acute Coronary Insufficiency Study (OACIS) Investigators, Low Levels of Serum n-3 Polyunsaturated Fatty Acids Are Associated With Worse Heart Failure-Free Survival in Patients After Acute Myocardial Infarction, Circulation Journal, 2013, Volume 77, Issue 1, Pages 153-162, Released December 25, 2012, [Advance publication] Released October 06, 2012, Online ISSN 1347-4820, Print ISSN 1346-9843, https://doi.org/10.1253/circj.CJ-12-0875, https://www.jstage.jst.go.jp/article/circj/77/1/77_CJ-12-0875/_article/-char/en
DCTERMS.abstract	Background: Intake of long-chain n-3 polyunsaturated fatty acids (n-3 PUFA), including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), is associated with a lower risk of atherosclerotic cardiovascular events, particularly acute myocardial infarction (AMI). However, limited data are available regarding the association between serum n-3 PUFA levels and heart failure (HF) events in survivors of AMI. Methods and Results: We evaluated whether serum DHA and EPA levels were associated with HF-free survival and HF hospitalization rates after AMI. A total of 712 patients were divided into 3 groups according to their tertile serum levels of DHA and EPA (Low, Middle, and High). Propensity-score-stratified Cox regression analysis revealed that DHA- and EPA-Low groups presented statistically significant worse HF-free survival (hazard ratio (HR) 1.68, 95% confidence interval (CI) 1.03-2.72, P=0.0358, and HR 1.69, 95% CI 1.05-2.72, P=0.0280, respectively), with the EPALow group having a higher risk of HF hospitalization (HR 2.40, 95% CI 1.21-4.75, P=0.0097) than the DHA-Low group (HR 1.72, 95% CI 0.86-3.45, P=0.1224). The relationship between a low DHA or EPA level and decreased HF-free survival was almost common to all subgroups; however, the effect of low serum EPA on HF hospitalization was prominent in male patients, and those with low levels of high-density lipoprotein cholesterol or without statin therapy. Conclusions: Low levels of circulating n-3 PUFA are associated with decreased HF-free survival in post-AMI patients.
DC.format	78934
citation_title	Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction
citation_author	Hara, Masahiko
	Sakata, Yasuhiko
	Nakatani, Daisaku
	Suna, Shinichiro
	Usami, Masaya
	Matsumoto, Sen
	Hamasaki, Toshimitsu
	Doi, Yasuji
	Nishino, Masami
	Sato, Hiroshi
	Kitamura, Tetsuhisa
	Nanto, Shinsuke
	Hori, Masatsugu
	Komuro, Issei
citation_publisher	Japanese Circulation Society
citation_language	英語
citation_date	2012-12-25
citation_journal_title	Circulation Journal
citation_volume	77
citation_issue	1
citation_firstpage	153
citation_lastpage	162
citation_doi	https://doi.org/10.1253/circj.CJ-12-0875
citation_pmid	23047296
citation_public_url	https://hdl.handle.net/11094/78934

Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction

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