学術雑誌論文

学術雑誌論文

text

PLoS ONE. 2017, 12(8), p. e0183298

Interdependency and phosphorylation of KIF4 and condensin I are essential for organization of chromosome scaffold

Public Library of Science

英語

text

2017-08-17

https://doi.org/10.1371/journal.pone.0183298

Poonperm R, Takata H, Uchiyama S, Fukui K (2017) Interdependency and phosphorylation of KIF4 and condensin I are essential for organization of chromosome scaffold. PLOS ONE 12(8): e0183298. https://doi.org/10.1371/journal.pone.0183298.

Kinesin family member 4 (KIF4) and condensins I and II are essential chromosomal proteins for chromosome organization by locating primarily to the chromosome scaffold. However, the mechanism of how KIF4 and condensins localize to the chromosome scaffold is poorly understood. Here, we demonstrate a close relationship between the chromosome localization of KIF4 and condensin I, but not condensin II, and show that KIF4 and condensin I assist each other for stable scaffold formation by forming a stable complex. Moreover, phosphorylation of KIF4 and condensin I by Aurora B and polo-like kinase 1 (Plk1) is important for KIF4 and condensin I localization to the chromosome. Aurora B activity facilitates the targeting of KIF4 and condensin I to the chromosome, whereas Plk1 activity promotes the dissociation of these proteins from the chromosome. Thus, the interdependency between KIF4 and condensin I, and their phosphorylation states play important roles in chromosome scaffold organization during mitosis.

© 2017 Poonperm et al. This article is licensed under a Creative Commons Attribution 4.0 International License.

79027

Interdependency and phosphorylation of KIF4 and condensin I are essential for organization of chromosome scaffold

Public Library of Science

英語

2017-08-17

PLoS ONE

12

8

e0183298

https://doi.org/10.1371/journal.pone.0183298

28817632

https://hdl.handle.net/11094/79027