170-MHz electrodeless quartz crystal microbalance biosensor : Capability and limitation of higher frequency measurement

Ogi, Hirotsugu; Nagai, Hironao; Fukunishi, Yuji; Hirao, Masahiko; Nishiyama, Masayoshi

doi:https://doi.org/10.1021/ac901267b

170-MHz electrodeless quartz crystal microbalance biosensor : Capability and limitation of higher frequency measurement

Ogi, Hirotsugu; Nagai, Hironao; Fukunishi, Yuji et al.

Analytical Chemistry, 2009, 81(19), 8068-8073

アクセス数:525件（2025-08-23 15:58 集計）

固定URL: https://hdl.handle.net/11094/84140

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タイトル	170-MHz electrodeless quartz crystal microbalance biosensor : Capability and limitation of higher frequency measurement
著者	NRID 1000090252626 1000090252626 researchmap permalink read0042771 read0042771 Scopus Author ID 35563683500 35563683500 著者名 Ogi, Hirotsugu
	著者名 Nagai, Hironao
	著者名 Fukunishi, Yuji
	NRID 1000080112027 1000080112027 著者名 Hirao, Masahiko
	著者名 Nishiyama, Masayoshi
内容	Hirotsugu Ogi, Hironao Nagai, Yuji Fukunishi, Masahiko Hirao, and Masayoshi Nishiyama. 170-MHz electrodeless quartz crystal microbalance biosensor: Capability and limitation of higher frequency measurement. Analytical Chemistry, 2009, 81(19), 8068-8073. ©2009 American Chemical Society. https://doi.org/10.1021/ac901267b.
抄録	We develop a highly sensitive quartz crystal microbalance (QCM) biosensor with a fundamental resonance frequency of 170 MHz. A naked AT-cut quartz plate of 9.7 μm thick is set in a sensor cell. Its shear vibration is excited by the line wire, and the vibration signals are detected by the other line wire, achieving the noncontacting measurement of the resonance frequency. The mass sensitivity of the 170 MHz QCM biosensor is 15 pg/(cm² Hz), which is better than that of a conventional 5 MHz QCM by 3 orders of magnitude. Its high sensitivity is confirmed by detecting human immunoglobulin G (hIgG) via Staphylococcus protein A immobilized nonspecifically on both surfaces of the quartz plate. The detection limit is 0.5 pM. Limitation of the high-frequency QCM measurement is then theoretically discussed with a continuum mechanics model for a plate with point masses connected by elastic springs. The result indicates that a QCM measurement will break down at frequencies one-order-of-magnitude higher than the local resonance frequency at specific binding cites.
出版者	American Chemical Society
収録物名	Analytical Chemistry
巻(号)	81(19)
ページ	8068-8073
刊行年月	2009-10-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/84140
PISSN	00032700
eISSN	15206882
NCID	AA00524878
関連情報 (isVersionOf)	DOI (出版社版) https://doi.org/10.1021/ac901267b
関連情報 (isIdenticalTo)	PMID 19728731
アクセス権	open access
権利情報	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Analytical Chemistry, © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/ac901267b.
出版タイプ	Accepted Manuscript
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Analytical Chemistry. 2009, 81(19), p. 8068-8073
DC.title	170-MHz electrodeless quartz crystal microbalance biosensor : Capability and limitation of higher frequency measurement
DC.creator	Ogi, Hirotsugu
	Nagai, Hironao
	Fukunishi, Yuji
	Hirao, Masahiko
	Nishiyama, Masayoshi
DC.publisher	American Chemical Society
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2009-10-01
DC.identifier	https://doi.org/10.1021/ac901267b
DC.description	Hirotsugu Ogi, Hironao Nagai, Yuji Fukunishi, Masahiko Hirao, and Masayoshi Nishiyama. 170-MHz electrodeless quartz crystal microbalance biosensor: Capability and limitation of higher frequency measurement. Analytical Chemistry, 2009, 81(19), 8068-8073. ©2009 American Chemical Society. https://doi.org/10.1021/ac901267b.
DCTERMS.abstract	We develop a highly sensitive quartz crystal microbalance (QCM) biosensor with a fundamental resonance frequency of 170 MHz. A naked AT-cut quartz plate of 9.7 μm thick is set in a sensor cell. Its shear vibration is excited by the line wire, and the vibration signals are detected by the other line wire, achieving the noncontacting measurement of the resonance frequency. The mass sensitivity of the 170 MHz QCM biosensor is 15 pg/(cm² Hz), which is better than that of a conventional 5 MHz QCM by 3 orders of magnitude. Its high sensitivity is confirmed by detecting human immunoglobulin G (hIgG) via Staphylococcus protein A immobilized nonspecifically on both surfaces of the quartz plate. The detection limit is 0.5 pM. Limitation of the high-frequency QCM measurement is then theoretically discussed with a continuum mechanics model for a plate with point masses connected by elastic springs. The result indicates that a QCM measurement will break down at frequencies one-order-of-magnitude higher than the local resonance frequency at specific binding cites.
DC.rights	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Analytical Chemistry, © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/ac901267b.
DC.format	84140
citation_title	170-MHz electrodeless quartz crystal microbalance biosensor : Capability and limitation of higher frequency measurement
citation_author	Ogi, Hirotsugu
	Nagai, Hironao
	Fukunishi, Yuji
	Hirao, Masahiko
	Nishiyama, Masayoshi
citation_publisher	American Chemical Society
citation_language	英語
citation_date	2009-10-01
citation_journal_title	Analytical Chemistry
citation_volume	81
citation_issue	19
citation_firstpage	8068
citation_lastpage	8073
citation_doi	https://doi.org/10.1021/ac901267b
citation_pmid	19728731
citation_public_url	https://hdl.handle.net/11094/84140

170-MHz electrodeless quartz crystal microbalance biosensor : Capability and limitation of higher frequency measurement

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