学術雑誌論文

学術雑誌論文

text

Applied Physics Express. 2009, 3(1), p. 017001

Label-free ultrathin Pt film biosensor using phonon vibrations excited by ultrafast light pulses

The Japan Society of Applied Physics

英語

text

2009-12-25

https://doi.org/10.1143/APEX.3.017001

Hirotsugu Ogi, Kozo Matsumoto, Yusaku Fujita, Tetsuya Kawamoto, Nobutomo Nakamura and Masahiko Hirao. Label-free ultrathin Pt film biosensor using phonon vibrations excited by ultrafast light pulses. Applied Physics Express, 2010, 3(1), 017001. https://doi.org/10.1143/APEX.3.017001.

An ultrathin film oscillator biosensor is presented for highly sensitive monitoring of binding reactions among biomolecules in solutions. The phonon vibration along the thickness direction of an 18-nm Pt film is measured by ultrafast light pulses, whose fundamental resonance frequency is 120 GHz. The vibrational amplitude is monitored during binding reaction between human immunoglobulin G (hIgG) and anti-hIgG antibody, which exponentially decreases as the reaction progresses. A 6 pM hIgG solution can be detected. This biosensor also shows the ability to determine the affinity between proteins through the concentration dependence of the reaction rate.

84154

Label-free ultrathin Pt film biosensor using phonon vibrations excited by ultrafast light pulses

The Japan Society of Applied Physics

英語

2009-12-25

Applied Physics Express

3

1

017001

https://doi.org/10.1143/APEX.3.017001

https://hdl.handle.net/11094/84154