Noninvasive vessel-selective perfusion imaging with intravenous myocardial contrast echocardiography

Asanuma, Toshihiko; Fujihara, Tomoko; Otani, Kentaro; Miki, Ayako; Ishikura, Fuminobu; Beppu, Shintaro

doi:https://doi.org/10.1016/j.echo.2004.03.011

Noninvasive vessel-selective perfusion imaging with intravenous myocardial contrast echocardiography

Asanuma, Toshihiko; Fujihara, Tomoko; Otani, Kentaro et al.

Journal of the American Society of Echocardiography, 2004, 17(6), 654-658

アクセス数:595件（2026-04-05 17:59 集計）

固定URL: https://hdl.handle.net/11094/86995

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タイトル	Noninvasive vessel-selective perfusion imaging with intravenous myocardial contrast echocardiography
著者	NRID 1000080379271 1000080379271 著者名 Asanuma, Toshihiko
	著者名 Fujihara, Tomoko
	NRID 1000050470191 1000050470191 著者名 Otani, Kentaro
	著者名 Miki, Ayako
	NRID 1000050303970 1000050303970 著者名 Ishikura, Fuminobu
	NRID 1000040113500 1000040113500 著者名 Beppu, Shintaro
内容	Asanuma T, Fujihara T, Otani K, Miki A, Ishikura F, Beppu S. Noninvasive vessel-selective perfusion imaging with intravenous myocardial contrast echocardiography. J Am Soc Echocardiogr. 2004 Jun;17(6):654-8. doi: 10.1016/j.echo.2004.03.011.
抄録	Background Intravenous myocardial contrast echocardiography (MCE) cannot identify each perfusion area of coronary vessels separately. However, by destroying microbubbles passing through a specific vessel using high-power ultrasound during intravenous MCE, vessel-selective perfusion imaging (VSPI) may be feasible. Methods In 10 open-chest dogs, intermittent short-axis images were obtained during contrast agent infusion using an ultrasound system. For VSPI, a probe coupled to another ultrasound machine was placed on the proximal left circumflex coronary artery (LCx). High-power ultrasound pulses were transmitted to destroy bubbles passing through the LCx. A negative contrast area on VSPI was considered to represent the perfusion area of the LCx (LCx-VSPI). A negative contrast area on conventional MCE during LCx occlusion and a region without staining by Evans blue dye were used as gold standards for defining the LCx perfusion area. LCx-VSPI was compared with a negative contrast area on conventional MCE during LCx occlusion and a region without staining by Evans blue dye. Results Despite lack of LCx occlusion, high-power destructive pulses produced a definite area of negative contrast on the LCx region. Decreased power of ultrasound pulses resulted in disappearance of the negative contrast area. An excellent relationship was demonstrated between both LCx-VSPI and a negative contrast area on conventional MCE during LCx occlusion (r = 0.93, P < .0001), and LCx-VSPI and a region without staining by Evans blue dye (r = 0.92, P = .0002). Conclusion: VSPI during intravenous MCE may be feasible for noninvasive assessment of perfusion areas associated with specific vessels.
出版者	C.V. Mosby
収録物名	Journal of the American Society of Echocardiography
巻(号)	17(6)
ページ	654-658
刊行年月	2004-06
言語	英語
ハンドルURL	https://hdl.handle.net/11094/86995
PISSN	08947317
NCID	AA10709494
関連情報 (isVersionOf)	DOI (出版社版) https://doi.org/10.1016/j.echo.2004.03.011
関連情報 (isIdenticalTo)	PMID 15163938
アクセス権	open access
権利情報	This manuscript version is made available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
出版タイプ	Accepted Manuscript
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of the American Society of Echocardiography. 2004, 17(6), p. 654-658
DC.title	Noninvasive vessel-selective perfusion imaging with intravenous myocardial contrast echocardiography
DC.creator	Asanuma, Toshihiko
	Fujihara, Tomoko
	Otani, Kentaro
	Miki, Ayako
	Ishikura, Fuminobu
	Beppu, Shintaro
DC.publisher	C.V. Mosby
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2004-06
DC.identifier	https://doi.org/10.1016/j.echo.2004.03.011
DC.description	Asanuma T, Fujihara T, Otani K, Miki A, Ishikura F, Beppu S. Noninvasive vessel-selective perfusion imaging with intravenous myocardial contrast echocardiography. J Am Soc Echocardiogr. 2004 Jun;17(6):654-8. doi: 10.1016/j.echo.2004.03.011.
DCTERMS.abstract	Background Intravenous myocardial contrast echocardiography (MCE) cannot identify each perfusion area of coronary vessels separately. However, by destroying microbubbles passing through a specific vessel using high-power ultrasound during intravenous MCE, vessel-selective perfusion imaging (VSPI) may be feasible. Methods In 10 open-chest dogs, intermittent short-axis images were obtained during contrast agent infusion using an ultrasound system. For VSPI, a probe coupled to another ultrasound machine was placed on the proximal left circumflex coronary artery (LCx). High-power ultrasound pulses were transmitted to destroy bubbles passing through the LCx. A negative contrast area on VSPI was considered to represent the perfusion area of the LCx (LCx-VSPI). A negative contrast area on conventional MCE during LCx occlusion and a region without staining by Evans blue dye were used as gold standards for defining the LCx perfusion area. LCx-VSPI was compared with a negative contrast area on conventional MCE during LCx occlusion and a region without staining by Evans blue dye. Results Despite lack of LCx occlusion, high-power destructive pulses produced a definite area of negative contrast on the LCx region. Decreased power of ultrasound pulses resulted in disappearance of the negative contrast area. An excellent relationship was demonstrated between both LCx-VSPI and a negative contrast area on conventional MCE during LCx occlusion (r = 0.93, P < .0001), and LCx-VSPI and a region without staining by Evans blue dye (r = 0.92, P = .0002). Conclusion: VSPI during intravenous MCE may be feasible for noninvasive assessment of perfusion areas associated with specific vessels.
DC.rights	This manuscript version is made available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
DC.format	86995
citation_title	Noninvasive vessel-selective perfusion imaging with intravenous myocardial contrast echocardiography
citation_author	Asanuma, Toshihiko
	Fujihara, Tomoko
	Otani, Kentaro
	Miki, Ayako
	Ishikura, Fuminobu
	Beppu, Shintaro
citation_publisher	C.V. Mosby
citation_language	英語
citation_date	2004-06
citation_journal_title	Journal of the American Society of Echocardiography
citation_volume	17
citation_issue	6
citation_firstpage	654
citation_lastpage	658
citation_doi	https://doi.org/10.1016/j.echo.2004.03.011
citation_pmid	15163938
citation_public_url	https://hdl.handle.net/11094/86995

Noninvasive vessel-selective perfusion imaging with intravenous myocardial contrast echocardiography

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