Development of a mesoscopic framework spanning nanoscale protofibril dynamics to macro-scale fibrin clot formation

Takeishi, Naoki; Shigematsu, Taiki; Enosaki, Ryogo; Ishida, Shunichi; Ii, Satoshi; Wada, Shigeo

doi:https://doi.org/10.1098/rsif.2021.0554

Development of a mesoscopic framework spanning nanoscale protofibril dynamics to macro-scale fibrin clot formation

Takeishi, Naoki; Shigematsu, Taiki; Enosaki, Ryogo et al.

Journal of the Royal Society Interface, 2021, 18(184), 20210554

アクセス数:848件（2025-08-28 10:55 集計）

固定URL: https://hdl.handle.net/11094/88626

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タイトル	Development of a mesoscopic framework spanning nanoscale protofibril dynamics to macro-scale fibrin clot formation
著者	NRID 1000030787669 1000030787669 ORCID 0000-0002-9568-8711 0000-0002-9568-8711 researchmap permalink ntakeishi ntakeishi Scopus Author ID 55180234600 55180234600 著者名 Takeishi, Naoki
	NRID 1000050775765 1000050775765 researchmap permalink shigematsu_1990 shigematsu_1990 Scopus Author ID 56195177700 56195177700 著者名 Shigematsu, Taiki
	著者名 Enosaki, Ryogo
	NRID 1000080824169 1000080824169 著者名 Ishida, Shunichi
	NRID 1000050513016 1000050513016 著者名 Ii, Satoshi
	NRID 1000070240546 1000070240546 researchmap permalink shigeo41010 shigeo41010 Scopus Author ID 7401983636 7401983636 著者名 Wada, Shigeo
キーワード等	computational modelling
	fibrin clot
	mesoscopic dynamics
	protofibril
内容	Takeishi Naoki, Shigematsu Taiki, Enosaki Ryogo, Ishida Shunichi, Ii Satoshi and Wada Shigeo 2021Development of a mesoscopic framework spanning nanoscale protofibril dynamics to macro-scale fibrin clot formationJ. R. Soc. Interface.182021055420210554 http://doi.org/10.1098/rsif.2021.0554
抄録	Thrombi form a micro-scale fibrin network consisting of an interlinked structure of nanoscale protofibrils, resulting in haemostasis. It is theorized that the mechanical effect of the fibrin clot is caused by the polymeric protofibrils between crosslinks, or to their dynamics on a nanoscale order. Despite a number of studies, however, it is still unknown, how the nanoscale protofibril dynamics affect the formation of the macro-scale fibrin clot and thus its mechanical properties. A mesoscopic framework would be useful to tackle this multi-scale problem, but it has not yet been established. We thus propose a minimal mesoscopic model for protofibrils based on Brownian dynamics, and performed numerical simulations of protofibril aggregation. We also performed stretch tests of polymeric protofibrils to quantify the elasticity of fibrin clots. Our model results successfully captured the conformational properties of aggregated protofibrils, e.g., strain-hardening response. Furthermore, the results suggest that the bending stiffness of individual protofibrils increases to resist extension.
出版者	Royal Society Publishing
収録物名	Journal of the Royal Society Interface
巻(号)	18(184)
ページ	20210554
刊行年月	2021-11-10
言語	英語
ハンドルURL	https://hdl.handle.net/11094/88626
PISSN	17425689
eISSN	17425662
NCID	AA12061165
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1098/rsif.2021.0554
関連情報 (isIdenticalTo)	PMID 34753310
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Journal of the Royal Society Interface. 2021, 18(184), p. 20210554
DC.title	Development of a mesoscopic framework spanning nanoscale protofibril dynamics to macro-scale fibrin clot formation
DC.creator	Takeishi, Naoki
	Shigematsu, Taiki
	Enosaki, Ryogo
	Ishida, Shunichi
	Ii, Satoshi
	Wada, Shigeo
DC.publisher	Royal Society Publishing
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2021-11-10
DC.identifier	https://doi.org/10.1098/rsif.2021.0554
DC.subject	computational modelling
	fibrin clot
	mesoscopic dynamics
	protofibril
DC.description	Takeishi Naoki, Shigematsu Taiki, Enosaki Ryogo, Ishida Shunichi, Ii Satoshi and Wada Shigeo 2021Development of a mesoscopic framework spanning nanoscale protofibril dynamics to macro-scale fibrin clot formationJ. R. Soc. Interface.182021055420210554 http://doi.org/10.1098/rsif.2021.0554
DCTERMS.abstract	Thrombi form a micro-scale fibrin network consisting of an interlinked structure of nanoscale protofibrils, resulting in haemostasis. It is theorized that the mechanical effect of the fibrin clot is caused by the polymeric protofibrils between crosslinks, or to their dynamics on a nanoscale order. Despite a number of studies, however, it is still unknown, how the nanoscale protofibril dynamics affect the formation of the macro-scale fibrin clot and thus its mechanical properties. A mesoscopic framework would be useful to tackle this multi-scale problem, but it has not yet been established. We thus propose a minimal mesoscopic model for protofibrils based on Brownian dynamics, and performed numerical simulations of protofibril aggregation. We also performed stretch tests of polymeric protofibrils to quantify the elasticity of fibrin clots. Our model results successfully captured the conformational properties of aggregated protofibrils, e.g., strain-hardening response. Furthermore, the results suggest that the bending stiffness of individual protofibrils increases to resist extension.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	88626
citation_title	Development of a mesoscopic framework spanning nanoscale protofibril dynamics to macro-scale fibrin clot formation
citation_author	Takeishi, Naoki
	Shigematsu, Taiki
	Enosaki, Ryogo
	Ishida, Shunichi
	Ii, Satoshi
	Wada, Shigeo
citation_publisher	Royal Society Publishing
citation_language	英語
citation_date	2021-11-10
citation_journal_title	Journal of the Royal Society Interface
citation_volume	18
citation_issue	184
citation_firstpage	20210554
citation_doi	https://doi.org/10.1098/rsif.2021.0554
citation_pmid	34753310
citation_public_url	https://hdl.handle.net/11094/88626

Development of a mesoscopic framework spanning nanoscale protofibril dynamics to macro-scale fibrin clot formation

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