学術雑誌論文

学術雑誌論文

text

Scientific Reports. 2017, 7, p. 5381

Capture of microparticles by bolus flow of red blood cells in capillaries

Springer Nature

英語

text

2017-07-14

https://doi.org/10.1038/s41598-017-05924-7

Takeishi, N., Imai, Y. Capture of microparticles by bolus flow of red blood cells in capillaries. Sci Rep 7, 5381 (2017). https://doi.org/10.1038/s41598-017-05924-7

Previous studies have concluded that microparticles (MPs) can more effectively approach the microvessel wall than nanoparticles because of margination. In this study, however, we show that MPs are not marginated in capillaries where the vessel diameter is comparable to that of red blood cells (RBCs). We numerically investigated the behavior of MPs with a diameter of 1 μm in various microvessel sizes, including capillaries. In capillaries, the flow mode of RBCs shifted from multi-file flow to bolus (single-file) flow, and MPs were captured by the bolus flow of the RBCs instead of being marginated. Once MPs were captured, they rarely escaped from the vortex-like flow structures between RBCs. These capture events were enhanced when the hematocrit was decreased, and reduced when the shear rate was increased. Our results suggest that microparticles may be rather inefficient drug carriers when targeting capillaries because of capture events, but nanoparticles, which are more randomly distributed in capillaries, may be more effective carriers.

This article is licensed under a Creative Commons Attribution 4.0 International License.

88653

Capture of microparticles by bolus flow of red blood cells in capillaries

Springer Nature

英語

2017-07-14

Scientific Reports

7

5381

https://doi.org/10.1038/s41598-017-05924-7

28710401

https://hdl.handle.net/11094/88653