Flow of a circulating tumor cell and red blood cells in microvessels

Takeishi, Naoki; Imai, Yohsuke; Yamaguchi, Takami; Ishikawa, Takuji

doi:https://doi.org/10.1103/PhysRevE.92.063011

Flow of a circulating tumor cell and red blood cells in microvessels

Takeishi, Naoki; Imai, Yohsuke; Yamaguchi, Takami et al.

Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, 2015, 92(6), 063011

アクセス数:775件（2026-10-28 22:54 集計）

固定URL: https://hdl.handle.net/11094/88654

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タイトル	Flow of a circulating tumor cell and red blood cells in microvessels
著者	NRID 1000030787669 1000030787669 ORCID 0000-0002-9568-8711 0000-0002-9568-8711 researchmap permalink ntakeishi ntakeishi Scopus Author ID 55180234600 55180234600 著者名 Takeishi, Naoki
	NRID 1000060431524 1000060431524 著者名 Imai, Yohsuke
	NRID 1000030101843 1000030101843 著者名 Yamaguchi, Takami
	NRID 1000020313728 1000020313728 著者名 Ishikawa, Takuji
内容	Takeishi N., Imai Y., Yamaguchi T., et al. Flow of a circulating tumor cell and red blood cells in microvessels. Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, 92, 6, 063011. https://doi.org/10.1103/PhysRevE.92.063011.
抄録	Quantifying the behavior of circulating tumor cells (CTCs) in the blood stream is of fundamental importance for understanding metastasis. Here, we investigate the flow mode and velocity of CTCs interacting with red blood cells (RBCs) in various sized microvessels. The flow of leukocytes in microvessels has been described previously; a leukocyte forms a train with RBCs in small microvessels and exhibits margination in large microvessels. Important differences in the physical properties of leukocytes and CTCs result from size. The dimensions of leukocytes are similar to those of RBCs, but CTCs are significantly larger. We investigate numerically the size effects on the flow mode and the cell velocity, and we identify similarities and differences between leukocytes and CTCs. We find that a transition from train formation to margination occurs when (R-a)/tR≈1, where R is the vessel radius, a is the cell radius, and tR is the thickness of RBCs, but that the motion of RBCs differs from the case of leukocytes. Our results also show that the velocities of CTCs and leukocytes are larger than the average blood velocity, but only CTCs move faster than RBCs for microvessels of R/a≈1.5-2.0. These findings are expected to be useful not only for understanding metastasis, but also for developing microfluidic devices.
出版者	American Physical Society
収録物名	Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
巻(号)	92(6)
ページ	063011
刊行年月	2015-12-09
言語	英語
ハンドルURL	https://hdl.handle.net/11094/88654
PISSN	15393755
eISSN	15502376
NCID	AA11558033
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1103/PhysRevE.92.063011
関連情報 (isIdenticalTo)	PMID 26764808
アクセス権	open access
権利情報	Copyright 2015 by the American Physical Society
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 2015, 92(6), p. 063011
DC.title	Flow of a circulating tumor cell and red blood cells in microvessels
DC.creator	Takeishi, Naoki
	Imai, Yohsuke
	Yamaguchi, Takami
	Ishikawa, Takuji
DC.publisher	American Physical Society
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2015-12-09
DC.identifier	https://doi.org/10.1103/PhysRevE.92.063011
DC.description	Takeishi N., Imai Y., Yamaguchi T., et al. Flow of a circulating tumor cell and red blood cells in microvessels. Physical Review E - Statistical, Nonlinear, and Soft Matter Physics, 92, 6, 063011. https://doi.org/10.1103/PhysRevE.92.063011.
DCTERMS.abstract	Quantifying the behavior of circulating tumor cells (CTCs) in the blood stream is of fundamental importance for understanding metastasis. Here, we investigate the flow mode and velocity of CTCs interacting with red blood cells (RBCs) in various sized microvessels. The flow of leukocytes in microvessels has been described previously; a leukocyte forms a train with RBCs in small microvessels and exhibits margination in large microvessels. Important differences in the physical properties of leukocytes and CTCs result from size. The dimensions of leukocytes are similar to those of RBCs, but CTCs are significantly larger. We investigate numerically the size effects on the flow mode and the cell velocity, and we identify similarities and differences between leukocytes and CTCs. We find that a transition from train formation to margination occurs when (R-a)/tR≈1, where R is the vessel radius, a is the cell radius, and tR is the thickness of RBCs, but that the motion of RBCs differs from the case of leukocytes. Our results also show that the velocities of CTCs and leukocytes are larger than the average blood velocity, but only CTCs move faster than RBCs for microvessels of R/a≈1.5-2.0. These findings are expected to be useful not only for understanding metastasis, but also for developing microfluidic devices.
DC.rights	Copyright 2015 by the American Physical Society
DC.format	88654
citation_title	Flow of a circulating tumor cell and red blood cells in microvessels
citation_author	Takeishi, Naoki
	Imai, Yohsuke
	Yamaguchi, Takami
	Ishikawa, Takuji
citation_publisher	American Physical Society
citation_language	英語
citation_date	2015-12-09
citation_journal_title	Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
citation_volume	92
citation_issue	6
citation_firstpage	063011
citation_doi	https://doi.org/10.1103/PhysRevE.92.063011
citation_pmid	26764808
citation_public_url	https://hdl.handle.net/11094/88654

Flow of a circulating tumor cell and red blood cells in microvessels

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