Ibandronate Suppresses Changes in Apatite Orientation and Young's Modulus Caused by Estrogen Deficiency in Rat Vertebrae

Ishimoto, Takuya; Saito, Mitsuru; Ozasa, Ryosuke; Matsumoto, Yoshihiro; Nakano, Takayoshi

doi:https://doi.org/10.1007/s00223-021-00940-2

Ibandronate Suppresses Changes in Apatite Orientation and Young's Modulus Caused by Estrogen Deficiency in Rat Vertebrae

Ishimoto, Takuya; Saito, Mitsuru; Ozasa, Ryosuke et al.

Calcified Tissue International, 2022, 110, 736-745

アクセス数:162件（2025-04-03 21:29 集計）

固定URL: https://hdl.handle.net/11094/89750

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タイトル	Ibandronate Suppresses Changes in Apatite Orientation and Young's Modulus Caused by Estrogen Deficiency in Rat Vertebrae
著者	NRID 1000050508835 1000050508835 ORCID 0000-0003-0081-0591 0000-0003-0081-0591 researchmap permalink i_taku i_taku Scopus Author ID 35310484700 35310484700 著者名 Ishimoto, Takuya
	NRID 1000050301528 1000050301528 著者名 Saito, Mitsuru
	NRID 1000080845347 1000080845347 ORCID 0000-0002-2773-072X 0000-0002-2773-072X researchmap permalink ozasa_r ozasa_r Scopus Author ID 56202812400 56202812400 著者名 Ozasa, Ryosuke
	著者名 Matsumoto, Yoshihiro
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 著者名 Nakano, Takayoshi
キーワード等	Apatite orientation
	Bone quality
	Ibandronate
	Material anisotropy
	Mechanical integrity
	Osteoporosis
内容	Ishimoto T., Saito M., Ozasa R., et al. Ibandronate Suppresses Changes in Apatite Orientation and Young's Modulus Caused by Estrogen Deficiency in Rat Vertebrae. Calcified Tissue International, 110, 6, 736. https://doi.org/10.1007/s00223-021-00940-2.
抄録	Bone material quality is important for evaluating the mechanical integrity of diseased and/or medically treated bones. However, compared to the knowledge accumulated regarding changes in bone mass, our understanding of the quality of bone material is lacking. In this study, we clarified the changes in bone material quality mainly characterized by the preferential orientation of the apatite c-axis associated with estrogen deficiency-induced osteoporosis, and their prevention using ibandronate (IBN), a nitrogen-containing bisphosphonate. IBN effectively prevented bone loss and degradation of whole bone strength in a dose-dependent manner. The estrogen-deficient condition abnormally increased the degree of apatite orientation along the craniocaudal axis in which principal stress is applied; IBN at higher doses played a role in maintaining the normal orientation of apatite but not at lower doses. The bone size-independent Young's modulus along the craniocaudal axis of the anterior cortical shell of the vertebra showed a significant and positive correlation with apatite orientation; therefore, the craniocaudal Young’s modulus abnormally increased under estrogen-deficient conditions, despite a significant decrease in volumetric bone mineral density. However, the abnormal increase in craniocaudal Young's modulus did not compensate for the degradation of whole bone mechanical properties due to the bone loss. In conclusion, it was clarified that changes in the material quality, which are hidden in bone mass evaluation, occur with estrogen deficiency-induced osteoporosis and IBN treatment. Here, IBN was shown to be a beneficial drug that suppresses abnormal changes in bone mechanical integrity caused by estrogen deficiency at both the whole bone and material levels.
出版者	Springer
収録物名	Calcified Tissue International
巻(号)	110
ページ	736-745
刊行年月	2022-01-06
言語	英語
ハンドルURL	https://hdl.handle.net/11094/89750
PISSN	0171967X
eISSN	14320827
NCID	AA00141085
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1007/s00223-021-00940-2
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Calcified Tissue International. 2022, 110, p. 736-745
DC.title	Ibandronate Suppresses Changes in Apatite Orientation and Young's Modulus Caused by Estrogen Deficiency in Rat Vertebrae
DC.creator	Ishimoto, Takuya
	Saito, Mitsuru
	Ozasa, Ryosuke
	Matsumoto, Yoshihiro
	Nakano, Takayoshi
DC.publisher	Springer
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2022-01-06
DC.identifier	https://doi.org/10.1007/s00223-021-00940-2
DC.subject	Apatite orientation
	Bone quality
	Ibandronate
	Material anisotropy
	Mechanical integrity
	Osteoporosis
DC.description	Ishimoto T., Saito M., Ozasa R., et al. Ibandronate Suppresses Changes in Apatite Orientation and Young's Modulus Caused by Estrogen Deficiency in Rat Vertebrae. Calcified Tissue International, 110, 6, 736. https://doi.org/10.1007/s00223-021-00940-2.
DCTERMS.abstract	Bone material quality is important for evaluating the mechanical integrity of diseased and/or medically treated bones. However, compared to the knowledge accumulated regarding changes in bone mass, our understanding of the quality of bone material is lacking. In this study, we clarified the changes in bone material quality mainly characterized by the preferential orientation of the apatite c-axis associated with estrogen deficiency-induced osteoporosis, and their prevention using ibandronate (IBN), a nitrogen-containing bisphosphonate. IBN effectively prevented bone loss and degradation of whole bone strength in a dose-dependent manner. The estrogen-deficient condition abnormally increased the degree of apatite orientation along the craniocaudal axis in which principal stress is applied; IBN at higher doses played a role in maintaining the normal orientation of apatite but not at lower doses. The bone size-independent Young's modulus along the craniocaudal axis of the anterior cortical shell of the vertebra showed a significant and positive correlation with apatite orientation; therefore, the craniocaudal Young’s modulus abnormally increased under estrogen-deficient conditions, despite a significant decrease in volumetric bone mineral density. However, the abnormal increase in craniocaudal Young's modulus did not compensate for the degradation of whole bone mechanical properties due to the bone loss. In conclusion, it was clarified that changes in the material quality, which are hidden in bone mass evaluation, occur with estrogen deficiency-induced osteoporosis and IBN treatment. Here, IBN was shown to be a beneficial drug that suppresses abnormal changes in bone mechanical integrity caused by estrogen deficiency at both the whole bone and material levels.
DC.rights	This article is licensed under a Creative Commons Attribution 4.0 International License.
DC.format	89750
citation_title	Ibandronate Suppresses Changes in Apatite Orientation and Young's Modulus Caused by Estrogen Deficiency in Rat Vertebrae
citation_author	Ishimoto, Takuya
	Saito, Mitsuru
	Ozasa, Ryosuke
	Matsumoto, Yoshihiro
	Nakano, Takayoshi
citation_publisher	Springer
citation_language	英語
citation_date	2022-01-06
citation_journal_title	Calcified Tissue International
citation_volume	110
citation_firstpage	736
citation_lastpage	745
citation_doi	https://doi.org/10.1007/s00223-021-00940-2
citation_public_url	https://hdl.handle.net/11094/89750

Ibandronate Suppresses Changes in Apatite Orientation and Young's Modulus Caused by Estrogen Deficiency in Rat Vertebrae

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