Octacalcium phosphate crystals including a higher density dislocation improve its materials osteogenecity

Hamai, Ryo; Sakai, Susumu; Shiwaku, Yukari; Anada, Takahisa; Tsuchiya, Kaori; Ishimoto, Takuya; Nakano, Takayoshi; Suzuki, Osamu

doi:https://doi.org/10.1016/j.apmt.2021.101279

Octacalcium phosphate crystals including a higher density dislocation improve its materials osteogenecity

Hamai, Ryo; Sakai, Susumu; Shiwaku, Yukari et al.

Applied Materials Today, 2022, 26, 101279

アクセス数:168件（2025-04-03 22:22 集計）

固定URL: https://hdl.handle.net/11094/89754

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タイトル	Octacalcium phosphate crystals including a higher density dislocation improve its materials osteogenecity
著者	著者名 Hamai, Ryo
	著者名 Sakai, Susumu
	著者名 Shiwaku, Yukari
	著者名 Anada, Takahisa
	著者名 Tsuchiya, Kaori
	NRID 1000050508835 1000050508835 ORCID 0000-0003-0081-0591 0000-0003-0081-0591 researchmap permalink i_taku i_taku Scopus Author ID 35310484700 35310484700 著者名 Ishimoto, Takuya
	NRID 1000030243182 1000030243182 ORCID 0000-0001-8052-1698 0000-0001-8052-1698 researchmap permalink read0013987 read0013987 Scopus Author ID 7403896013 7403896013 著者名 Nakano, Takayoshi
	NRID 1000060374948 1000060374948 著者名 Suzuki, Osamu
キーワード等	Dislocation
	Dissolution
	Lattice strain
	Octacalcium phosphate
	Osteogenecity
内容	Hamai R., Sakai S., Shiwaku Y., et al. Octacalcium phosphate crystals including a higher density dislocation improve its materials osteogenecity. Applied Materials Today, 26, 101279. https://doi.org/10.1016/j.apmt.2021.101279.
抄録	Herein, we show that the enhanced osteogenecity of octacalcium phosphate (OCP) biomaterial, recently identified as an important element in hybrid organic–inorganic nanocomposites involved in the initial hydroxyapatite crystal expansion in mammal bones, results from an enhanced chemical property, stemming from the presence of lattice strain and dislocations. Two types of OCPs were synthesized by wet-chemical processing in the presence (c-OCP) and absence (w-OCP) of gelatin, respectively, and subjected to structural, chemical, and biological analyses. High-resolution transmission electron microscopy (HRTEM) and fast Fourier transform (FFT) analyses revealed that c-OCP crystals contained approximately six times higher edge dislocations with Burgers vectors perpendicular to a-axis than that in the case of w-OCP. The dissolution of c-OCP crystal in tris-HCl buffer occurred toward the long axis of the crystal, most likely, toward the lattice strain along the c-axis direction, while w-OCP crystal dissolved toward the a-axis direction. The study suggested that the increment of internal energy by the higher dislocation density contributed promoting c-OCP dissolution and hydrolysis through decreasing the activation energy. c-OCP crystal displayed enhanced in vitro mesenchymal stem 2D cell and 3D spheroid differentiation, in vivo bone formation, and apatite crystallographic orientation in critical-sized rat calvarial defect model as compared to w-OCP crystal, at the same time, converting to apatite structure earlier than w-OCP. The present study demonstrates that dislocation-related dissolution along with enhanced conversion of OCP is a determinant in bone induction, which may be relevant to normal bone development utilizing OCP biomaterials.
出版者	Elsevier
収録物名	Applied Materials Today
巻(号)	26
ページ	101279
刊行年月	2022-03-01
言語	英語
ハンドルURL	https://hdl.handle.net/11094/89754
eISSN	23529407
関連情報 (isIdenticalTo)	DOI (出版社版) https://doi.org/10.1016/j.apmt.2021.101279
アクセス権	open access
権利情報	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
出版タイプ	Version of Record
カテゴリ	学術雑誌論文 Journal Article

資源タイプ	学術雑誌論文
ローカル資源タイプ	学術雑誌論文
DCMI資源タイプ	text
DCTERMS.bibliographicCitation	Applied Materials Today. 2022, 26, p. 101279
DC.title	Octacalcium phosphate crystals including a higher density dislocation improve its materials osteogenecity
DC.creator	Hamai, Ryo
	Sakai, Susumu
	Shiwaku, Yukari
	Anada, Takahisa
	Tsuchiya, Kaori
	Ishimoto, Takuya
	Nakano, Takayoshi
	Suzuki, Osamu
DC.publisher	Elsevier
DC.language' scheme='DCTERMS.RFC1766	英語
DC.type' scheme='DCTERMS.DCMIType	text
DCTERMS.issued' scheme='DCTERMS.W3CDTF	2022-03-01
DC.identifier	https://doi.org/10.1016/j.apmt.2021.101279
DC.subject	Dislocation
	Dissolution
	Lattice strain
	Octacalcium phosphate
	Osteogenecity
DC.description	Hamai R., Sakai S., Shiwaku Y., et al. Octacalcium phosphate crystals including a higher density dislocation improve its materials osteogenecity. Applied Materials Today, 26, 101279. https://doi.org/10.1016/j.apmt.2021.101279.
DCTERMS.abstract	Herein, we show that the enhanced osteogenecity of octacalcium phosphate (OCP) biomaterial, recently identified as an important element in hybrid organic–inorganic nanocomposites involved in the initial hydroxyapatite crystal expansion in mammal bones, results from an enhanced chemical property, stemming from the presence of lattice strain and dislocations. Two types of OCPs were synthesized by wet-chemical processing in the presence (c-OCP) and absence (w-OCP) of gelatin, respectively, and subjected to structural, chemical, and biological analyses. High-resolution transmission electron microscopy (HRTEM) and fast Fourier transform (FFT) analyses revealed that c-OCP crystals contained approximately six times higher edge dislocations with Burgers vectors perpendicular to a-axis than that in the case of w-OCP. The dissolution of c-OCP crystal in tris-HCl buffer occurred toward the long axis of the crystal, most likely, toward the lattice strain along the c-axis direction, while w-OCP crystal dissolved toward the a-axis direction. The study suggested that the increment of internal energy by the higher dislocation density contributed promoting c-OCP dissolution and hydrolysis through decreasing the activation energy. c-OCP crystal displayed enhanced in vitro mesenchymal stem 2D cell and 3D spheroid differentiation, in vivo bone formation, and apatite crystallographic orientation in critical-sized rat calvarial defect model as compared to w-OCP crystal, at the same time, converting to apatite structure earlier than w-OCP. The present study demonstrates that dislocation-related dissolution along with enhanced conversion of OCP is a determinant in bone induction, which may be relevant to normal bone development utilizing OCP biomaterials.
DC.rights	This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
DC.format	89754
citation_title	Octacalcium phosphate crystals including a higher density dislocation improve its materials osteogenecity
citation_author	Hamai, Ryo
	Sakai, Susumu
	Shiwaku, Yukari
	Anada, Takahisa
	Tsuchiya, Kaori
	Ishimoto, Takuya
	Nakano, Takayoshi
	Suzuki, Osamu
citation_publisher	Elsevier
citation_language	英語
citation_date	2022-03-01
citation_journal_title	Applied Materials Today
citation_volume	26
citation_firstpage	101279
citation_doi	https://doi.org/10.1016/j.apmt.2021.101279
citation_public_url	https://hdl.handle.net/11094/89754

Octacalcium phosphate crystals including a higher density dislocation improve its materials osteogenecity

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